Results 131 to 140 of about 43,355 (293)

Innate immunity and neuroinflammation [PDF]

, 2013
Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
core   +3 more sources

Cellular senescence-associated gene IFI16 promotes HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma

Nature Communications
Glioblastoma multiforme (GBM) remains a therapeutic challenge due to its aggressive nature and recurrence. This study establishes a radioresistant GBM cell model through repeated irradiation and observes a cellular senescence-like phenotype in these ...
Yuchuan Zhou, Liang Zeng, Linbo Cai, Wang Zheng, Xinglong Liu, Yuqi Xiao, Xiaoya Jin, Yang Bai, Mingyao Lai, Hainan Li, Hua Jiang, Songling Hu, Yan Pan, Jianghong Zhang, Chunlin Shao   +14 more
doaj   +1 more source

Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis [PDF]

, 2020
Weijian Mai, Yangzhi Xu, Jiahui Xu, Dan Zhao, Liangying Ye, Ganxiang Yu, Zhilei Wang, Qianting Lu, Jiaen Lin, Tao Yang, Chengxin Gu, Shiming Liu, Yun Zhong, Hui Yang   +13 more
openalex   +1 more source

Xuanfei Baidu Formula Ameliorates Influenza A Virus-Induced Lung Inflammation by Repressing the NLRP3 Inflammasome in Macrophages

Engineering
The NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome is an intracellular protein complex containing a nucleotide-binding oligomerization domain, leucine-rich repeats, and a pyrin domain.
Tao Liu, Yueyuan Xu, Ziwei Yan, Lin Ma, Hongda Sheng, Mingyu Ding, Jiabao Wang, Qingdi Fang, Qianru Zhao, Yu Tang, Tianyuan Zhang, Lu Chen, Rui Shao, Bin Qu, Jing Qian, Yi Wang, Junhua Zhang, Xiaohuan Guo, Yu Wang, Han Zhang   +19 more
doaj   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Research progress on NLRP3 inflammasome regulation of periodontitis

Kouqiang hemian waike zazhi
Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing protein 3 (NLRP3) inflammasome is a multi-protein complex that exists in the cytoplasm.
LI Xuejing, SU Jiansheng
doaj   +1 more source

Accelerated apoptosis of neutrophils in familial Mediterranean fever

Frontiers in Immunology, 2015
The causative mutations for familial Mediterranean fever (FMF) are located in the MEFV gene, which encodes pyrin. Pyrin modulates the susceptibility to apoptosis via its PYD domain but how the mutated versions of pyrin affect apoptotic processes is ...
Gayane eManukyan, Rustam eAminov, Gagik eHakobyan, Tigran eDavtyan   +3 more
doaj   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

AMPK Phosphorylation Modulates Pain by Activation of NLRP3 Inflammasome [PDF]

, 2016
Impairment in adenosine monophosphate-activated protein kinase (AMPK) activity and NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation are associated with several metabolic and inflammatory diseases.
Alcocer-Gómez, Elísabet, Bullon, Pedro, Carrión, Ángel Manuel, Garrido Maraver, Juan, Marín-Aguilar, Fabiola, Román Malo, Lourdes Victoria   +5 more
core  

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source