Results 151 to 160 of about 43,355 (293)

Analysis Of Mefv Gene Alternatively Spliced Transcripts Expression Patterns In Cell Culture Models [PDF]

, 2014
Tez (Yüksek Lisans) -- İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2013Thesis (M.Sc.) -- İstanbul Technical University, Institute of Science and Technology, 2013Ailevi Akdeniz Ateşi (AAA), bölgemizdeki görülme sıklığı 1/200 ila 1/1073 arasında
Abacı, İrem
core  

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy

British Journal of Pharmacology, EarlyView.
Abstract Contemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear.
Zihan Qu, Jiajun Dong, Zhong‐Yin Zhang
wiley   +1 more source

The cytoskeleton in cell-autonomous immunity: structural determinants of host defence

, 2015
Host cells use antimicrobial proteins, pathogen-restrictive compartmentalization and cell death in their defence against intracellular pathogens. Recent work has revealed that four components of the cytoskeleton — actin, microtubules, intermediate ...
A Ablasser, A Akhter, A Desai, A Fukazawa, A Stolz, AB Jaffe, AF Frade, AJ Thrasher, AL Waite, AM Keestra, AP West, AR Shenoy, Avinash R. Shenoy, B Levine, B-H Kim, BB Mishra, BT Kile, C Stevens, C Watts, CM Haglund, CS Weirich, D Chen, D Ghosal, D Parker, D Sancho, DC Rubinsztein, DJ Philpott, DL Clemens, DM Underhill, E Bi, E Caron, EL Benanti, F Caudron, F Martinon, F Randow, F Randow, F Rees, G Bonizzi, G dos Santos, G Kuhlenbaumer, G Tran Van Nhieu, H Bielig, H Herrmann, H Sridharan, H Xu, HB Yu, HS Goodridge, I Monastyrska, IM Dambuza, J Eitel, J Huang, J Jin, J Li, J Li, J Pizarro-Cerdá, J Saarikangas, J Shi, J von Moltke, J-G Zhang, JA Hagar, JA Swanson, JC Kagan, JCH Tam, JD MacMicking, JJ Bravo-Cordero, JL Dangl, JP Solomon, JR Terman, JS Hyams, JSC Arthur, JW Jones, K Aktories, K Aktories, K Dobbs, K Gotoh, KL Angus, L Blanchoin, L Kong, L Le Bourhis, LA Cameron, LA Knodler, LJF Jones, M Kokes, M Lamkanfi, M Ogawa, M Ogawa, M Pasparakis, M Rosas, M Sasai, M Yoneyama, MA Al-Zeer, MA Gavrilin, MA Gavrilin, MA Gavrilin, MA Sanjuan, MB Torchinsky, MD Welch, MJG Eldridge, ML Kim, MT Cabeen, N Ausmees, N Carayol, N Kayagaki, N Kayagaki, N Mizushima, N Ostler, N Schroeder, N Subramanian, NE Harwood, NT Snider, P Cossart, P Hanc, P Wild, P Xia, PS Manzanillo, R Goldbach-Mansky, R Mackeh, R Muñoz-Planillo, RC Wang, RE Vance, S Ahrens, S Asrat, S Iborra, S Legrand-Poels, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Mostowy, S Park, S Savic, S Zelenay, SA Schattgen, SCO Reed, Serge Mostowy, SL Sandiford, SM Man, T Fernandes-Alnemri, T Kawai, T Misawa, T Strowig, T Tamura, TA Kufer, TD Pollard, TLM Thurston, U Golebiewska, V Deretic, VAK Rathinam, VAK Rathinam, W-D Hardt, WA McEwan, WM Schneider, X Cai, Y Aachoui, Y Aachoui, Y Kumar, Y Ma, Y Song, Y Tanaka-Takiguchi, Y Yoshikawa, Y Zhao, Y-W Huang, YT Zheng   +165 more
core   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Beyond diabetes and obesity: GLP‐1 receptor agonists in disrupting the vicious cycle of metabolic dysfunction and neuroinflammation

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Neurodegenerative diseases, including debilitating conditions like Alzheimer's and Parkinson's, are characterized by progressive neuronal loss, a process fundamentally driven by persistent chronic neuroinflammation and central metabolic dysfunction.
Renata Spezani, Carlos A. Mandarim‐de‐Lacerda   +1 more
wiley   +1 more source

Jefferson Alumni Bulletin – Volume 57, Number 2, Spring 2008 [PDF]

, 2008
Jefferson Alumni Bulletin – Volume 57, Number 2, Spring 2008 Dean\u27s Column; Page 2 Findings; Page 4 On Campus; Page 8 John H. Moore, Jr., MD, GS\u2784, FACS; Page 10 Out of the Office; Page 12 The Birth and Growth of a Medical School; Page 20 Class ...

core   +1 more source

The Role of Immune-related NLR Pyrin Domain Containing 2 (NLRP2) Gene in the Development and Diseases

, 2021
Fatemah Basingab, Asmaa Alghamdi, Safiah Alhazmi, Aisha Alrofaidi, Mona G. Alharbi   +4 more
openalex   +2 more sources

Genotype–phenotype associations of polymorphisms within the gene locus of NOD-like receptor pyrin domain containing 3 in Swiss inflammatory bowel disease patients [PDF]

, 2021
Priyatharsan Yoganathan, Jean‐Benoît Rossel, Sebastian Bruno Ulrich Jordi, Yannick Franc, Luc Biedermann, Benjamin Misselwitz, Martin Hausmann, Gerhard Rogler, Michael Scharl, Isabelle Frey‐Wagner, Karim Abdelrahman, Gentiana Ademi, Patrick Aepli, Amman Thomas, Claudia Anderegg, Anca-Teodora Antonino, Eva Archanioti, Eviano Arrigoni, Diana Bakker de Jong, Bruno M. Balsiger, Polat Bastürk, Peter Bauerfeind, Andrea Becocci, Dominique C. Belli, José M. Bengoa, Luc Biedermann, Janek Binek, Mirjam Blattmann, Stephan Boehm, Tujana Boldanova, Jan Borovicka, Christian Braegger, Stephan Brand, Lukas Brügger, Simon Brunner, Patrick Bühr, Bernard Burnand, Sabine Burk, Emanuel Burri, Sophie Buyse, Dahlia-Thao Cao, Ove Carstens, Dominique Criblez, Sophie Cunningham, Fabrizia D’Angelo, Philippe de Saussure, Lukas Degen, Joakim Delarive, Christopher Doerig, Barbara Dora, Susan Drerup, Mara Egger, Ali El-Wafa, Matthias Engelmann, Jessica Ezri, Christian Felley, Markus Fliegner, Nicolas Fournier, Montserrat Fraga, Yannick Franc, Pascal Frei, Remus Frei, Michael Fried, Florian Froehlich, Raoul I. Furlano, Luca Garzoni, Martin Geyer, Laurent Girard, Marc Girardin, Delphine Golay, Ignaz Good, Ulrike Graf Bigler, Beat Gysi, Johannes Haarer, Marcel Halama, Janine Haldemann, Pius Heer, Benjamin Heimgartner, Beat Helbling, Peter Hengstler, Denise Herzog, Cyrill Hess, Roxane Hessler, Klaas Heyland, Thomas Hinterleitner, Claudia Hirschi, Petr Hrúz, Pascal Juillerat, Carolina Khalid-de Bakker, Stephan Kayser, Céline Keller, Christina Knellwolf, Christoph Knoblauch, Henrik Köhler, Rebekka Koller, Claudia Krieger, Patrizia Künzler‐Heule, Rachel Kusche, Frank Serge Lehmann, Andrew J. Macpherson   +99 more
openalex   +1 more source