Results 181 to 190 of about 43,355 (293)

Significance of elevated serum and hepatic NOD-like receptor pyrin domain containing 3 (NLRP3) in hepatitis C virus-related liver disease. [PDF]

Sci Rep, 2022
Aggan HE, Mahmoud S, Deeb NE, Eleishi I, El-Shendidi A.   +4 more
europepmc   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Targeting the NOD-Like Receptor Pyrin Domain Containing 3 Inflammasome to Improve Healing of Diabetic Wounds. [PDF]

Adv Wound Care (New Rochelle), 2023
Cavalcante-Silva J, Koh TJ.
europepmc   +1 more source

The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways

, 2020
Jialu Zhou, Fan Zhang, Hong‐Ru Lin, Minxue Quan, Yaqin Yang, Yanni Lv, Zongnan He, Yisong Qian   +7 more
openalex   +1 more source

IGFBP4 is a Metric for Primary Biliary Cholangitis and Attenuates Biliary Epithelial Cell Injury

Liver International, Volume 46, Issue 3, March 2026.
ABSTRACT Background and Aims Immune‐mediated bile duct injury is the primary histological feature of autoimmune cholestatic liver diseases. Macrophages, the most abundant immune cell population in the liver, have been postulated to play a critical role in biliary repair. However, it is unclear whether activated macrophages interact with injured biliary
Xing Zhou, Shuyu Shao, Danning Yang, Ziyan Cheng, Toshihiro Tanaka, Patrick S. C. Leung, Koichi Tsuneyama, Aftab A. Ansari, William M. Ridgway, Pietro Invernizzi, Christopher L. Bowlus, M. Eric Gershwin, Weici Zhang   +12 more
wiley   +1 more source

Choroid plexus alterations in long COVID and their associations with Alzheimer's disease risks

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Choroid plexus (ChP) enlargement is a neuroimaging biomarker of neuroinflammation and neurodegeneration. However, evidence of ChP structural and perfusion alterations in long coronavirus disease (COVID) and their clinical relevance remains limited.
Huize Pang, Jennifer Frontera, Li Jiang, Chenyang Li, Allal Boutajangout, Zhe Sun, Ludovic Debure, Mobeena Ghuman, Alok Vedvyas, Arjun V. Masurkar, Thomas Wisniewski, Yulin Ge   +11 more
wiley   +1 more source

The Inflammasome NLR Family Pyrin Domain-Containing Protein 3 (NLRP3) as a Novel Therapeutic Target for Idiopathic Pulmonary Fibrosis. [PDF]

Am J Pathol, 2022
Colunga Biancatelli RML, Solopov PA, Catravas JD.   +2 more
europepmc   +1 more source

Activation of caspase-1 is mediated by stimulation of interferon genes and NLR family pyrin domain containing 3 in monocytes of active systemic lupus erythematosus

, 2022
Shoichiro Inokuchi, Hiroki Mitoma, Shotaro Kawano, Masahiro Ayano, Yasutaka Kimoto, Mitsuteru Akahoshi, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro   +9 more
openalex   +2 more sources

NLR family pyrin domain containing 3 (NLRP3; NALP3) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

Rhein Inhibits NLRP3 Activation and Alleviates Microglial Pyroptosis After Intracerebral Hemorrhage in Rats

Brain and Behavior, Volume 16, Issue 2, February 2026.
Rhein treatment inhibits NLRP3 inflammasome activation, suppresses Caspase‐1/GSDMD‐mediated pyroptosis, reduces pro‐inflammatory cytokine release, promotes M2 polarization, and improves behavioral outcomes of ICH. These findings suggest that rhein protects against ICH‐induced brain injury through the inhibition of NLRP3‐dependent pyroptosis ...
Adalaiti Aimaiti, Qian Li, Tao Liu, Chen Chen, Xiaolin Xie, Jianshu Chu, Dilihumaer Nuermaimaiti, Yan Hu   +7 more
wiley   +1 more source