Results 221 to 230 of about 43,355 (293)

Molecular dynamics simulations reveal the impact of Ser295 phosphorylation on the structure of pyrin domain-containing NOD-like receptor 3 [PDF]

Christina F. Sandall, Justin A. MacDonald   +1 more
openalex   +1 more source

Mechanistic Insights and Therapeutic Potential of Small Nucleolar RNA Host Genes in the Carcinogenesis of Hepatocellular Carcinoma

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) is one of the major factors endangering human health due to its poor prognosis, resulting from difficulties in early diagnosis and lack of effective treatment measures. Long non‐coding RNAs (lncRNAs), which are RNA molecules that do not translate into proteins, play essential roles in various tumor ...
Jiajia Luo, Zhangxiu Liao, Shuangxia Zhang   +2 more
wiley   +1 more source

Identification of WT161 as a Potent Agent for the Treatment of Colitis by Targeting the Nucleotide-Binding Domain-Like Receptor Family Pyrin Domain Containing 3 Inflammasome. [PDF]

Front Pharmacol, 2022
Long X, Yu X, Gong P, Wang X, Tian L.
europepmc   +1 more source

Depression Aggravates Immune‐Mediated Hepatitis Through NLRP3 Overactivation Induced by Intestinal Microbiota

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Depression is common in AIH patients and is associated with an elevated cirrhosis risk. AIH patients with depression, mice colonized with MDD microbiota, and ConA‐treated mice subjected to CUMS exhibit intestinal barrier dysfunction and hepatic NLRP3 inflammasome overactivation.
Simin Zhou, Liping Guo, Nian Chen, Haifeng Liu, Xin Liu, Jiwen Li, Shijing Dong, Jiangpeng Liu, Xiaoyi Wang, Ying Ran, Man Liu, Hongyu Chu, Yanni Li, Hui Yang, Jingwen Zhao, Lu Zhou   +15 more
wiley   +1 more source

Nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 inflammasome: From action mechanism to therapeutic target in clinical trials. [PDF]

World J Gastrointest Oncol
Zhang CY, Liu S, Sui YX, Yang M.
europepmc   +1 more source

Semaglutide attenuates seizure severity and ameliorates cognitive dysfunction by blocking the NLR family pyrin domain containing 3 inflammasome in pentylenetetrazole‑kindled mice. [PDF]

Int J Mol Med, 2021
Wang L, Ding J, Zhu C, Guo B, Yang W, He W, Li X, Wang Y, Li W, Wang F, Sun T.   +10 more
europepmc   +1 more source

The Interface of Oral and Brain Health: Current Insights Into the Bidirectional Relationship Between Alzheimer's Disease and Periodontitis

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Bidirectional Pathogenesis Between AD and Periodontitis. Periodontal pathogens reach the brain via hematogenous/trigeminal/oral–intestinal pathways, triggering neuroinflammation and Aβ plaques to drive AD. Conversely, AD disrupts bone homeostasis (via Aβ, endocrine/autonomic dysregulation) to aggravate periodontitis.
Weidong Zhang, Shasha Li, Yajun Cui, Yuhui Lun, Hongrui Liu, Minqi Li   +5 more
wiley   +1 more source

Long noncoding RNA X-inactive specific transcript regulates NLR family pyrin domain containing 3/caspase-1-mediated pyroptosis in diabetic nephropathy. [PDF]

World J Diabetes, 2022
Xu J, Wang Q, Song YF, Xu XH, Zhu H, Chen PD, Ren YP.   +6 more
europepmc   +1 more source

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei, Mingyue Liuyuan, Zhixin Ye, Xueying Wang, Xueli Zhou, Yifan Shan, Cheng He, Chunting Zhu, Chicheng Zhou, Jingyin Bao, Yonghui Zhang, Gang Chen   +11 more
wiley   +1 more source

The antiarthritic effect of CBR-470-1 in hypoxic environment is to increase the level of NOD-like receptor family pyrin domain containing 3 ubiquitination by decreasing phosphoglycerate kinase 1 activity. [PDF]

Clin Transl Med
Duan A, Ma Z, Shao X, Xiong Z, Zhang C, Liu W, Wang G, Hu S, Lin W.   +8 more
europepmc   +1 more source