Long noncoding RNA maternally expressed gene 3 improves trophoblast dysfunction and inflammation in preeclampsia through the Wnt/β-Catenin/nod-like receptor pyrin domain-containing 3 axis. [PDF]
Front Mol Biosci, 2022 Liang Y, Wang P, Shi Y, Cui B, Meng J.
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Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.Graphical Abstract ABSTRACT Objective Diabetic retinopathy (DR) is characterised by chronic neuroinflammation where the NLRP3 inflammasome plays a pivotal role. This study investigated the therapeutic potential and underlying mechanism of combining systemic metformin (MET) with intravitreal MCC950, a specific NLRP3 inhibitor, in a rodent model of DR ...
Kexuan Ren, Xiaofeng Li
wiley +1 more source
AR-A014418, a glycogen synthase kinase-3β inhibitor, mitigates lipopolysaccharide-induced inflammation in rat dental pulp stem cells via NLR family pyrin domain containing 3 inflammasome impairment. [PDF]
J Dent Sci, 2023 Xie H, Lin Y, Fang F.
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Serum Uric Acid as a Mediator of Insulin Resistance: Molecular Mechanisms and Metabolic Pathways
Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.Elevated SUA can lead to oxidative stress, endothelial dysfunction, inflammation and impaired function of adipocytes—all of which collectively impede insulin receptor activity and downstream signalling. Key pathways involved include activation of the NLRP3 inflammasome, suppression of AMPK and induction of mitochondrial dysfunction.
Nurshad Ali
wiley +1 more source
3,4-methylenedioxymethamphetamine induces reactive oxygen species-mediated autophagy and thioredoxin-interactive protein/nucleotide-binding domain, leucine-rich containing family, pyrin domain-containing-3 inflammasome activation in dental pulp stem cells. [PDF]
J Dent SciLee SY, Chiu SW, Li IH, Tsai WC, Li CH.
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Imperatorin alleviated NLR family pyrin domain-containing 3 inflammasome cascade-induced synovial fibrosis and synovitis in rats with knee osteoarthritis. [PDF]
Bioengineered, 2021 Zhang H +9 more
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Food Frontiers, Volume 7, Issue 1, January 2026.CY alleviates colitis and associated neuropsychiatric symptoms by reducing serum LPS, restoring intestinal barrier integrity, and modulating serotonin metabolism. It inhibits neuroinflammation, improves synaptic function, and normalizes HPA axis hyperactivity via downregulation of HTR2C, offering a multi‐targeted strategy for gut–brain axis dysfunction
Yifan Cui +9 more
wiley +1 more source
Herpes Simplex Virus 1 Induces Microglia Gasdermin D-Dependent Pyroptosis Through Activating the NLR Family Pyrin Domain Containing 3 Inflammasome. [PDF]
Front Microbiol, 2022 Hu X +11 more
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Post‐Covid Alzheimer and Its Remediation via PROTACs Therapy: A Comprehensive Review
Health Science Reports, Volume 9, Issue 1, January 2026.ABSTRACT Background and Aims Alzheimer's disease (AD) is a progressive neurodegenerative disorder of aging characterized by memory loss and cognitive decline, associated with amyloid‐β toxicity, tau hyperphosphorylation, and neurofibrillary tangle formation. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) affects the central nervous system
Teesta Bhowmick +5 more
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Wogonin ameliorates the proliferation, inflammatory response, and pyroptosis in keratinocytes via NOD-like receptor family pyrin domain containing 3/Caspase-1/Gasdermin-D pathway. [PDF]
Immun Inflamm DisMa J, Ji C, Sun Y, Liu D, Pan K, Wei Y.
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