Results 241 to 250 of about 43,355 (293)

Hepatitis E virus infection activates NOD-like receptor family pyrin domain-containing 3 inflammasome antagonizing interferon response but therapeutically targetable. [PDF]

Hepatology, 2022
Li Y, Yu P, Kessler AL, Shu J, Liu X, Liang Z, Liu J, Li Y, Li P, Wang L, Wang Y, Ma Z, Liu A, Wang L, Bruno MJ, de Man RA, Peppelenbosch MP, Buschow SI, Wang L, Wang Y, Pan Q.   +20 more
europepmc   +1 more source

a-c: Scatter plot representing the correlation between placental NLRP-3 (a), IL-1β (b) and D6 (c) expression with maternal BMI. NLRP-3: NLR family pyrin domain containing 3; IL-1β: interleukin 1 beta; CRD6: chemokine scavenger decoy receptor D6; BMI: body mass index.

Marianna Onori (21560575), Giuliana Beneduce (6585638), Filomena Colella (20632435), Donatella Lucchetti (6739862), Caterina Policola (21560578), Vincenzo Arena (3400187), Fabio Sannino (21560581), Alessandro Petrecca (21560584), Dario Pitocco (285807), Alfredo Pontecorvi (409818), Alessandro Sgambato (831734), Giovanni Scambia (14643), Nicoletta Di Simone (336266), Tullio Ghi (20194901), Chiara Tersigni (11352287)   +14 more
openalex   +1 more source

Ramalin Ameliorates Alzheimer's Disease Pathology by Targeting BACE1, HDAC6, and MAPK Pathways

MedComm, Volume 7, Issue 1, January 2026.
Ramalin alleviates Alzheimer's disease pathology by selectively inhibiting HDAC6, reducing BACE1 levels, and suppressing neuroinflammation through downregulation of the NLRP3 inflammasome and iNOS. It restores synaptic function impaired by Aβ toxicity and improves cognitive performance in AD mouse models, APP/PS1 and 3xTg‐AD.
Yongeun Cho, Jeongmi Lee, Bo Youn Choi, Jin‐Ho Yun, Sukmin Han, Seung Hyun Baek, Jinsu Park, Yoonsuk Cho, Hark Kyun Kim, Eunae Kim, Leon F. Palomera, Jeein Lim, Yeji Jeon, Jeonghyeong Im, Ju‐Mi Hong, Tai Kyoung Kim, Sung Hyun Kim, Joung Han Yim, Dong‐Gyu Jo   +18 more
wiley   +1 more source

Anti‐Inflammatory Properties of Ripe and Unripe Papaya Pectin in a Neonatal Human Stem Cell‐Derived Ileum Model

Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.
This study tested pectin from ripe and unripe papayas on a neonatal human stem cell‐derived intestinal model, with and without commensal Escherichia coli (E. coli). Both pectins improved cell health and reduced IL‐6, but only unripe pectin lowered IL‐8.
Janaina Lombello Santos Donadio, João Paulo Fabi, Helena M. Crowley, Marcelo B. Sztein, Rosângela Salerno‐Gonçalves   +4 more
wiley   +1 more source

Inter-relationships of galectin-3 and NLR family pyrin domain containing 3 inflammasomes with oral lichen planus: a preliminary cross-sectional in vitro study. [PDF]

BMC Oral Health
Chen S, Xu X, Liu Y, Yao Y, Yang Y, Meng W.   +5 more
europepmc   +1 more source

β‐Hydroxybutyrate Acts as an Exercise Mimetic to Protect the Aging Liver

Aging Cell, Volume 25, Issue 1, January 2026.
β‐hydroxybutyrate (β‐HB) acts as an exercise mimetic to protect the aging liver. In aged models, exercise‐induced β‐HB delays liver aging by reversing macrophage senescence, blocking mtDNA/cGAS‐STING‐driven inflammation, and alleviating hepatocyte lipid deposition/PANoptosis.
Ke Li, Lian Wang, Danlin Zhu, Wenhong Wang, Yifan Guo, Haoyang Gao, Muge Zhou, Weihua Xiao   +7 more
wiley   +1 more source

Inhibition of phosphoinositide 3-kinase activity attenuates neutrophilic airway inflammation and inhibits pyrin domain-containing 3 inflammasome activation in an ovalbumin-lipopolysaccharide-induced asthma murine model. [PDF]

Mol Biol Rep
Li Q, Jiang G, Lv Y.
europepmc   +1 more source

Comparative evaluation of the levels of nod-like receptor family pyrin domain-containing protein (NLRP) 3 in saliva of subjects with chronic periodontitis and healthy controls.

J Indian Soc Periodontol, 2022
Mitra DK, Chavan RR, Prithyani SS, Kandawalla SA, Shah RA, Rodrigues SV.   +5 more
europepmc   +1 more source

Comparing Functional Consequences of Human iPSC‐Microglia and Neural Stem Cell‐Derived Extracellular Vesicles in Mitigating Cognitive Decline in Alzheimer's Disease

Aging Cell, Volume 25, Issue 1, January 2026.
Systemic (retro‐orbital vein) recurrent injections of human iPSC‐microglia and neural stem cell‐derived extracellular vesicles in a 5xFAD mouse model of Alzheimer's disease significantly improve cortex‐dependent cognitive function, reduce amyloid beta plaques, mitigate microglial and astrocytic activation, deliver neuroprotective miRNA cargo, and ...
Robert P. Krattli Jr., Mineh Markarian, Shreya Madan, Devyani Swami, Amanda McQuade, Janet E. Baulch, Matthew Blurton‐Jones, Munjal M. Acharya   +7 more
wiley   +1 more source

Integrated biomarker landscape for the early detection and management of calcific aortic valve disease

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Calcific aortic valve disease (CAVD), the leading valvular disorder in older adults, progresses from sclerosis to severe stenosis without effective medical therapies, making early non‐invasive detection essential. Circulating and mechanistic biomarkers reflect core pathogenic axes, including lipid oxidation, inflammation, mineral metabolism ...
Alberto Cook‐Calvete, Silvia Moreta, Maria Delgado‐Marin, Blanca Fernandez‐Rodriguez, Carlos Zaragoza, Marta Saura   +5 more
wiley   +1 more source