Results 261 to 270 of about 43,355 (293)

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease

Journal of Tropical Medicine, Volume 2026, Issue 1, 2026.
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Caroline de Souza Ferreira Pereira, Robson Xavier Faria, Wei Wang   +2 more
wiley   +1 more source

Bidirectional Regulation of NLRP3 Inflammasome and Mitochondrial Quality Control in Sepsis: Mechanisms and Therapeutic Implications

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Characterized by its capacity to induce organ failure, sepsis constitutes a life‐threatening pathological state with high incidence and mortality rates. Current treatments primarily focus on antimicrobial therapy and organ support, lacking direct interventions targeting the restoration of cellular or organelle function.
Xiangxin Liao, Yixun Wang, Zhaohui Zhang, Xingguang Qu, Gaosheng Zhou, Laurent L′homme   +5 more
wiley   +1 more source

NLR family pyrin domain containing 3 (NLRP3; NALP3; CIAS1); IL-1β [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Pyd and Card domain containing (Pycard; Asc); Nlr family, pyrin domain containing 3 (Nlrp3; Nalp3) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Compatibility with Fructus Ligustri Lucidi Effectively Mitigates Idiosyncratic Liver Injury of Epimedii Folium by Modulating NOD-like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation

Xiaomei Zhao, Zhixin Wu, Yan Wang, Yingjie Xu, Xiu Ye, Dong Xu, Junjie Li, Gui-Ji Lv, Sihao Wang, Yurong Li, Zhaofang Bai, Xiaohe Xiao   +11 more
openalex   +1 more source

Identification of New Inhibitors for Homotypic Interaction of Pyrin Domain of Nlrp3 Protein in Inflammasome Structure Through Screening of a Novel Library

Saman Hosseinkhani, Nuredin Bakhtiary, Maryam Peyvandi, Alexander Dömlingꝉ   +3 more
openalex   +1 more source

NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome at the crossroads of dysbiosis and disease: A target for microbiome-modulated inflammation

Shishir Singh, Rajeev Nema, Monisha Banerjee, Atar Singh Kushwah   +3 more
openalex   +1 more source

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An Assay for the Seeding of Homotypic Pyrin Domain Filament Transitions

2022
Pattern recognition receptors of innate immune cells allow the recognition of invariant microbial structures. The nucleotide-binding oligomerization domain-like receptors (NLRs) comprise 22 members, divided into 3 subfamilies. Homotypic pyrin domain (PYD) interactions were shown to mediate the interaction of inflammasome forming NLRPs with the adaptor ...
Inga V, Hochheiser, Matthias, Geyer
openaire   +2 more sources

Pyrin N-Terminal Homology Domain- and Caspase Recruitment Domain-Dependent Oligomerization of ASC

Biochemical and Biophysical Research Communications, 2001
ASC was first identified as a caspase recruitment domain (CARD)-containing proapoptotic molecule that forms insoluble aggregates during apoptosis. Here, we report both the pyrin N-terminal homology domain (PYD) and CARD domains are involved in the aggregation of ASC.
J, Masumoto, S, Taniguchi, J, Sagara
openaire   +2 more sources

Structural and Functional Analysis of Mutated Human Pyrin B30.2 Domain

Current Proteomics, 2020
Background: Familial Mediterranean Fever (FMF) is a prototypical hereditary autoinflammatory disease affecting principally Mediterranean populations and characterized by recurrent frequent fever and inflammation. The disease is essentially caused by inherited mutations in the MEFV gene which encodes pyrin protein.
Sepideh Parvizpour, Ashraf Fadhil Jomah, Jafar Razmara   +2 more
openaire   +1 more source