Results 271 to 280 of about 43,355 (293)
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PYRIN domain of NALP2 inhibits cell proliferation and tumor growth of human glioblastoma
Plasmid, 2010NACHT leucine-rich domain and pyrin-containing protein 2 (NALP2) plays a crucial role in inflammation through regulation of NF-kappaB activity. The N-terminal PRYIN domain of NALP2 (PYD) functions similarly in inhibiting NF-kappaB activity. To investigate if NALP2 or PYD regulates cell proliferation or tumor growth of glioblastoma, lentiviruses ...
Guo-Qing, Wu +7 more
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Complex formation dynamics of native and mutated pyrin's B30.2 domain with caspase‐1
Proteins: Structure, Function, and Bioinformatics, 2018AbstractPyrin protein is the product of the MEFV gene, mutations in which cause manifestation of familial Mediterranean fever (FMF). Functions of pyrin are not completely clear. The secondary structure of the pyrin is represented with four domains and two motifs.
Grigor Arakelov +2 more
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PYRIN domains and their interactions in the apoptosis and inflammation signaling pathway
Apoptosis, 2012The PYRIN domain (PYD) is a well known protein interaction module and a prime mediator of the protein interactions necessary for apoptosis, inflammation and innate immune signaling pathway. Because PYD-mediated apoptosis, inflammation and innate immune processes are associated with many human diseases, studies in these areas are of great biological ...
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Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2021
Alzheimer's disease(AD)is a chronic neurodegenerative disease whose cause remains unclear.The β-amyloid plaques in the brain are one of the major pathological features of AD.However,the drugs targeting extracellular β-amyloid plaques have failed to cure the disease.Innate immunity and neuroinflammation play a role in the pathogenesis and progression of
Yun-Ying, Feng, Hui, Chen
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Alzheimer's disease(AD)is a chronic neurodegenerative disease whose cause remains unclear.The β-amyloid plaques in the brain are one of the major pathological features of AD.However,the drugs targeting extracellular β-amyloid plaques have failed to cure the disease.Innate immunity and neuroinflammation play a role in the pathogenesis and progression of
Yun-Ying, Feng, Hui, Chen
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AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence
Nature, 2021Sangjoon Lee, , Yaqiu Wang
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HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation
Science, 2020Venkat Giri Magupalli +2 more
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Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis
Nature Immunology, 2020Elaine F Remmers +2 more
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Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis
Cellular and Molecular Immunology, 2023, Sangjoon Lee
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The NLRP3 inflammasome: molecular activation and regulation to therapeutics
Nature Reviews Immunology, 2019Karen V Swanson, Meng Deng
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