Results 31 to 40 of about 43,355 (293)

Bufei Huoxue capsule alleviates silicosis by inhibiting the activation of nucleotide-like receptor containing pyrin domain 3 inflammasome and macrophages polarization based on network pharmacology. [PDF]

J Tradit Chin Med
Wenlu H, Lin W, Yun BO, Shurun Z, Songquan W, Haiquan LI, Chunlu BU, Jie Z, Xianmei Z.   +8 more
europepmc   +3 more sources

miR-23a-5p Alleviates Gouty Inflammation by Targeting Interleukin-17A and Inhibiting NLR Family Pyrin Domain Containing 3 Inflammasome Activation. [PDF]

Arch Rheumatol
Yuan X, Lin C, Zhang Y, He H, Li L.
europepmc   +3 more sources

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. [PDF]

, 2010
Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18. We elucidate here how host macrophages recognize F.
Alnemri, Emad S, Datta, Pinaki, Eisenlohr, Laurence, Fernandes-Alnemri, Teresa, Huang, Lan, Juliana, Christine, Kang, Seokwon, Landel, Carlisle P, McCormick, Margaret, McDermott, Erin, Solorzano, Leobaldo, Wu, Jianghong, Yu, Je-Wook   +12 more
core   +8 more sources

Mutations in the B30.2 and the central helical scaffold domains of pyrin differentially affect inflammasome activation

Cell Death and Disease, 2023
Familial Mediterranean Fever (FMF) is the most common monogenic autoinflammatory disorder. FMF is caused by mutations in the MEFV gene, encoding pyrin, an inflammasome sensor.
Daria Chirita, Pauline Bronnec, Flora Magnotti, Sarah Dalmon, Amandine Martin, Michel Popoff, Mathieu Gerfaud-Valentin, Pascal Sève, Alexandre Belot, Anne Contis, Agnes Duquesne, Gaetane Nocturne, Irene Lemelle, Sophie Georgin-Lavialle, Guilaine Boursier, Isabelle Touitou, Yvan Jamilloux, Thomas Henry   +17 more
doaj   +1 more source

The mysterious role of the NLRP9 pyrin domain in inflammasome assembly. [PDF]

FEBS Lett, 2020
de Alba E.
europepmc   +4 more sources

The Death-domain Fold of the ASC PYRIN Domain, Presenting a Basis for PYRIN/PYRIN Recognition [PDF]

Journal of Molecular Biology, 2003
The PYRIN domain is a conserved sequence motif identified in more than 20 human proteins with putative functions in apoptotic and inflammatory signalling pathways. The three-dimensional structure of the PYRIN domain from human ASC was determined by NMR spectroscopy. The structure determination reveals close structural similarity to death domains, death
Liepinsh, Edvards, Barbals, Raitis, Dahl, Edgar, Sharipo, Anatoly, Staub, Eike, Otting, Gottfried   +5 more
openaire   +3 more sources

POP1 inhibits MSU-induced inflammasome activation and ameliorates gout

Frontiers in Immunology, 2022
Canonical inflammasomes are innate immune protein scaffolds that enable the activation of inflammatory caspase-1, and subsequently the processing and release of interleukin (IL)-1β, IL-18, and danger signals, as well as the induction of pyroptotic cell ...
Lucia de Almeida, Savita Devi, Mohanalaxmi Indramohan, Qi-Quan Huang, Rojo A. Ratsimandresy, Richard M. Pope, Andrea Dorfleutner, Andrea Dorfleutner, Andrea Dorfleutner, Christian Stehlik, Christian Stehlik, Christian Stehlik, Christian Stehlik   +12 more
doaj   +1 more source

Autophagy Induced by Micheliolide Alleviates Acute Irradiation-Induced Intestinal Injury via Inhibition of the NLRP3 Inflammasome

Frontiers in Pharmacology, 2022
Radiation-induced enteropathy (RIE) is one of the most common and fatal complications of abdominal radiotherapy, with no effective interventions available.
Dong-ming Wu, Dong-ming Wu, Dong-ming Wu, Jing Li, Jing Li, Rong Shen, Jin Li, Jin Li, Ye Yu, Ye Yu, Li Li, Li Li, Shi-hua Deng, Shi-hua Deng, Teng Liu, Teng Liu, Ting Zhang, Ting Zhang, Ying Xu, Ying Xu, De-gui Wang   +20 more
doaj   +1 more source

Progress on the role of NLRP3 inflammasome in hyperuricemic nephropathy [PDF]

Jichu yixue yu linchuang, 2023
Hyperuricemic nephropathy (HN) is a common clinical complication of hyperuricemia, leading to hyperuricemia-associated renal abnormalities. The present review sheds light on the mechanistic aspects pertaining to HN, emphasizing the role of nucleotide ...
DAI Zhixin, WANG Yumin
doaj   +1 more source

Pyrin Domain (PYD)-containing Inflammasome in Innate Immunity [PDF]

Journal of Bacteriology and Virology, 2011
Inflammasome is a cytosolic multiprotein complex to activate caspase-1 leading to the subsequent processing of inactive pro-interleukin-1-beta (Pro-IL-1β) into its active interleukin-1 beta (IL-1β) in response to pathogen- or dangerassociated molecular pattern.
Sujeong Hong, Sangjun Park, Je‐Wook Yu
openalex   +3 more sources