Results 41 to 50 of about 43,355 (293)
Identification of Multifaceted Binding Modes for Pyrin and ASC Pyrin Domains Gives Insights into Pyrin Inflammasome Assembly [PDF]
Journal of Biological Chemistry, 2014 Inflammasomes are macromolecular complexes that mediate inflammatory and cell death responses to pathogens and cellular stress signals. Dysregulated inflammasome activation is associated with autoinflammatory syndromes and several common diseases. During inflammasome assembly, oligomerized cytosolic pattern recognition receptors recruit procaspase-1 ...
Vajjhala, Parimala R. +6 more
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Differential Binding of NLRP3 to non-oxidized and Ox-mtDNA mediates NLRP3 Inflammasome Activation
Communications Biology, 2023 The NLRP3 inflammasome is a key mediator of the innate immune response to sterile tissue injury and is involved in many chronic and acute diseases. Physically and chemically diverse agents activate the NLRP3 inflammasome.
Angela Cabral +8 more
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Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich–Containing Family, Pyrin Domain–Containing-3) Inflammasome in Cardiovascular Disorders [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2018 Inflammation is an important innate immune response to infection or tissue damage. Inflammasomes are involved in the onset and development of inflammation. The NLRP3 (nucleotide-binding domain, leucine-rich–containing family, pyrin domain–containing-3) inflammasome is the best-characterized inflammasome.
Zheng Wang +7 more
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Pyrin Modulates the Intracellular Distribution of PSTPIP1. [PDF]
PLoS ONE, 2009 PSTPIP1 is a cytoskeleton-associated adaptor protein that links PEST-type phosphatases to their substrates. Mutations in PSTPIP1 cause PAPA syndrome (Pyogenic sterile Arthritis, Pyoderma gangrenosum, and Acne), an autoinflammatory disease.
Andrea L Waite +11 more
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Exosomes Regulate NLRP3 Inflammasome in Diseases
Frontiers in Cell and Developmental Biology, 2022 Emerging evidence has suggested the unique and critical role of exosomes as signal molecules vector in various diseases. Numerous researchers have been trying to identify how these exosomes function in immune progression, as this could promote their use ...
Zhangwang Li +8 more
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The PYRIN domain: A member of the death domain‐fold superfamily [PDF]
Protein Science, 2001 AbstractPYRIN domains were identified recently as putative protein–protein interaction domains at the N‐termini of several proteins thought to function in apoptotic and inflammatory signaling pathways. The ∼95 residue PYRIN domains have no statistically significant sequence homology to proteins with known three‐dimensional structure.
W J, Fairbrother +6 more
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The NLRP12 Pyrin Domain: Structure, Dynamics, and Functional Insights [PDF]
Journal of Molecular Biology, 2011 The initial line of defense against infection is sustained by the innate immune system. Together, membrane-bound Toll-like receptors and cytosolic nucleotide-binding domain and leucine-rich repeat-containing receptors (NLR) play key roles in the innate immune response by detecting bacterial and viral invaders as well as endogenous stress signals.
Anderson S, Pinheiro +4 more
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An updated view on the structure and function of PYRIN domains [PDF]
Apoptosis, 2014 The PYRIN domain (PYD) is a protein-protein interaction domain, which belongs to the death domain fold (DDF) superfamily. It is best known for its signaling function in innate immune responses and particularly in the assembly of inflammasomes, which are large protein complexes that allow the induced proximity-mediated activation of caspase-1 and ...
Lan H. Chu +3 more
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ASC Pyrin Domain Self-associates and Binds NLRP3 Protein Using Equivalent Binding Interfaces [PDF]
Journal of Biological Chemistry, 2016 Death domain superfamily members typically act as adaptors mediating in the assembly of supramolecular complexes with critical apoptosis and inflammation functions. These modular proteins consist of death domains, death effector domains, caspase recruitment domains, and pyrin domains (PYD).
Javier Oroz +4 more
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TIR, CARD and PYRIN: three domains for an antimicrobial triad [PDF]
Cell Death & Differentiation, 2006 Innate immunity to microorganisms in mammals has gained a substantial interest during the last decade. The discovery of the Toll-like receptor (TLR) family has allowed the identification of a class of membrane-spanning receptors dedicated to microbial sensing. TLRs transduce downstream signaling via their intracellular Toll-interleukin-1 receptor (TIR)
C, Werts, S E, Girardin, D J, Philpott
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