Results 31 to 40 of about 21,408 (184)

The Asp1 pyrophosphatase from S. pombe hosts a [2Fe-2S](2+) cluster in vivo [PDF]

, 2021
The Schizosaccharomyces pombe Asp1 protein is a bifunctional kinase/pyrophosphatase that belongs to the highly conserved eukaryotic diphosphoinositol pentakisphosphate kinase PPIP5K/Vip1 family.
Walla, Eva, Cutsail III, G., Span, Ingrid, Span, I., Birrell, J., Cutsail, George E, DeBeer, Serena, Fleig, Ursula, Rosenbach, Hannah, Rosenbach, H., DeBeer, S., Pascual-Ortiz, Marina, Pascual-Ortiz, M., Birrell, James A, Fleig, U., Walla, E., Serena DeBeer, Ursula Fleig, James A. Birrell, Eva Walla, Ingrid Span, George E. Cutsail, Marina Pascual-Ortiz, Hannah Rosenbach   +23 more
core   +1 more source

The inorganic pyrophosphatases of microorganisms: a structural and functional review [PDF]

PeerJ
Pyrophosphatases (PPases) are enzymes that catalyze the hydrolysis of pyrophosphate (PPi), a byproduct of the synthesis and degradation of diverse biomolecules. The accumulation of PPi in the cell can result in cell death.
Rodolfo García-Contreras, Javier de la Mora, Héctor Manuel Mora-Montes, José A. Martínez-Álvarez, Marcos Vicente-Gómez, Felipe Padilla-Vaca, Naurú Idalia Vargas-Maya, Bernardo Franco   +7 more
doaj   +2 more sources

ENPP1, an Old Enzyme with New Functions, and Small Molecule Inhibitors—A STING in the Tale of ENPP1

Molecules, 2019
Ectonucleotide pyrophosphatase/phosphodiesterase I (ENPP1) was identified several decades ago as a type II transmembrane glycoprotein with nucleotide pyrophosphatase and phosphodiesterase enzymatic activities, critical for purinergic signaling. Recently,
Kenneth I. Onyedibe, Modi Wang, Herman O. Sintim   +2 more
doaj   +1 more source

Npp1 prevents external tooth root resorption by regulation of cervical cementum integrity

Scientific Reports, 2022
Tooth roots embedded in the alveolar bone do not typically undergo resorption while the bone continues remodeling in its physiological state.
Hwajung Choi, Liu Yang, Yudong Liu, Ju-Kyung Jeong, Eui-Sic Cho   +4 more
doaj   +1 more source

Alkaline inorganic pyrophosphatase from guar (Cyamopsis tetragonoloba) cotyledons

, 1977
Alkaline inorganic pyrophosphatase from guar cotyledons was purified x 110 with about 34% recovery by (NH4)2SO4 fractionation, acetone ...
Singh, Randhir, Popli, Sarla, Sarla Popli, Randhir Singh   +3 more
core   +1 more source

Deficiency of the bone mineralization inhibitor NPP1 protects against obesity and diabetes [PDF]

, 2014
The emergence of bone as an endocrine regulator has prompted a re-evaluation of the role of bone mineralization factors in the development of metabolic disease.
Elspeth M. Milne, Ahmed, S Faisal, Zhu, Dongxing, Morton, Nicholas M, Millan, José Luis, MacRae, Vicky E, Mathieu Ferron, José Luis Millan, Dongxing Zhu, Nicholas M. Morton, Ferron, Mathieu, Farquharson, Colin, Karsenty, Gerard, Gerard Karsenty, Carmen Huesa, Vicky E. MacRae, Morton, Nicholas M., James D. Glover, Ahmed, S. Faisal, Glover, James D, Colin Farquharson, Huesa, Carmen, MacRae, Vicky E., S. Faisal Ahmed, Glover, James D., Milne, Elspeth M, Milne, Elspeth M., Farquharson, Colin; id_orcid   +27 more
core   +1 more source

Purification of Maize Nucleotide Pyrophosphatase/Phosphodiesterase Casts Doubt on the Existence of Zeatin Cis–Trans Isomerase in Plants

Frontiers in Plant Science, 2017
Almost 25 years ago, an enzyme named zeatin cis–trans isomerase from common bean has been described by Bassil et al. (1993). The partially purified enzyme required an external addition of FAD and dithiothreitol for the conversion of cis-zeatin to its ...
Tomáš Hluska, Marek Šebela, René Lenobel, Ivo Frébort, Petr Galuszka   +4 more
doaj   +1 more source

Pyrophosphatase and DNA Polymerase activity of wt and site-specific variants of α subunit.

, 2016
A) Pyrophosphatase activity of 17 nM wt (green dots), 17 nM H12A (blue dots), or 13 nM D19A (red dots) α subunit. B,C) DNA Polymerase activity as determined in the presence (B) or in the absence of E. coli inorganic pyrophosphatase (C).
Massimiliano Lanzi (1463971), Perceval Vellosillo Gonzalez (2601454), Alejandro Hochkoeppler (2082769), Fabio Lapenta (2601445), Sofia Perticarari (2601448), Alejandro Montón Silva (2601451), Renato Brandimarti (617022), Fabio Lino Gratani (2601457)   +7 more
core   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Properties and Distribution of Inorganic Pyrophosphatase in Rabbit Dental Pulp

, 1977
Some properties and the intracellular distribution of inorganic pyrophosphatase in rabbit dental pulp were determined. This enzyme was sensitive to Mg2+, and not inhibited by imidazol and CN- which are inhibitors of alkaline phosphatase.
Masae Mitsuma, Hiroshi Sugiya, Shunsuke Furuyama, Noriko Doi, Susumu Oyama   +4 more
core   +1 more source