Results 101 to 110 of about 101,444 (302)

Prevention of vascular calcification: is pyrophosphate therapy a solution? [PDF]

, 2011
Pyrophosphate, a ubiquitous small-molecule inhibitor of mineralization abundantly present in the extracellular environment, binds to calcium and mineral surfaces to inhibit crystal growth.
Marc D. McKee, Veerle P. Persy, Persy, Veerle P., McKee, Marc D.   +3 more
core   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Editorial: Pyrophosphates and Polyphosphates in Plants and Microorganisms

Frontiers in Plant Science, 2021
José R. Pérez-Castiñeira, Roberto Docampo, Tatsuhiro Ezawa, Aurelio Serrano   +3 more
doaj   +1 more source

Autonomous Control of Gene Expression Using Endogenous Transcription Signals

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Autonomous cell‐based control of heterologous gene expression can simplify batch‐culture bioprocessing by eliminating external monitoring and extrinsic control of culture conditions. Existing approaches use auto‐induction media, synthetic cell‐cell communication systems, or application‐specific biosensors.
Pakpoom Subsoontorn, Drew Endy, Olivier Borkowski   +2 more
wiley   +1 more source

Assessing Cofactor Usage in Pseudoclostridium thermosuccinogenes via Heterologous Expression of Central Metabolic Enzymes

Frontiers in Microbiology, 2019
Pseudoclostridium thermosuccinogenes and Hungateiclostridium thermocellum are being studied for their potential to contribute to a more sustainable bio-based economy.
Jeroen Girwar Koendjbiharie, Kimberly Wevers, Richard van Kranenburg, Richard van Kranenburg   +3 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Selective cleavage of pyrophosphate linkages

, 1992
Pyrophosphate linkages have a number of important roles in biology and are also formed chemically with great ease. They often are unwanted products, such as in the nonenzymatic oligomerization of mononucleotides.
Alan W. Schwartz, J. Visscher
core  

Myocardial Infarction without Coronary Artery Stenosis Illustrated by Tc- 99m Pyrophosphate Scan, Cardiac Magnetic Resonance Imaging, and Myocardial Perfusion Scintigraphy

, 2011
A 42-year-old woman presented with chest pain and ECG changes suggestive of acute myocardial infarction. However, a coronary angiogram showed no significant epicardial coronary stenosis.
鄭媚方;林彥宏;曾文毅;吳彥雯, CHENG, MEI-FANG;LIN, YEN-HUNG;TSENG, WEN-YIH;WU, YEN-WEN   +1 more
core   +1 more source

Carbon‐Based Electrodes for Sodium‐Ion Batteries: Material Design, Electrochemical Performance, and Challenges

Carbon and Hydrogen, EarlyView.
Carbon‐based electrodes, including graphite, graphene, and CNT composites, are promising candidates for sodium‐ion batteries due to their stability, conductivity, and abundance. Their electrochemical performance, key limitations, and strategies for improving practical SIB applications are highlighted.
Talha Munir, Rizwan Asghar, Mehboob Ur Rahman, Zaima Afzal   +3 more
wiley   +1 more source

Phosphonomethyl (Thio)Phosphonamidite Reagents for the Construction of Phosphonylmethyl Phosphono(Di)Thioate Mono‐ and Diesters

Chemistry – A European Journal, EarlyView.
A set of new phosphonomethyl (thio)phosphonamidite reagents is introduced to generate unprecedented pyrophosphate mimetics. The versatile P(III)‐P(V) reagents allow for the construction of various pyrophosphate isosteres, and the applicability of the chemistry is illustrated in the assembly of a diverse set of stabilized CDP‐glycerol and CDP‐ribitol ...
Pascal Balić, Roy Steneker, Gijsbert A. van der Marel, Jeroen D. C. Codée, Dmitri V. Filippov   +4 more
wiley   +1 more source