Results 311 to 320 of about 82,547 (381)

Hepatic steatosis and pyroptosis are induced by the hepatitis B virus X protein via B56α-METTL3 interaction-mediated m6A modification of the NLRP3 mRNA. [PDF]

Cell Death Dis
Du ZB, Han T, Cai YX, Shen YS, Wu JS, Li X, Zhong HT, Wu BH, Zhang L, Wen LY, Luo XM, Lin ZN, Lin YC.   +12 more
europepmc   +1 more source

Human Gut Commensal Bacteroides fragilis Suppresses Mucin Production and Alters Microbiota Composition Resulting in Accelerated Type 1 Diabetes in Mice

Immunology, EarlyView.
We show that gut colonisation of specific pathogen‐free (SPF) and germ‐free (GF) non‐obese diabetic (NOD) mice by Bacteroides fragilis (BF) at a juvenile age induces a pro‐inflammatory immune response and accelerated type 1 diabetes progression. Gut microbiota composition was different in control and BF‐colonised SPF mice, and the presence of BF alone ...
Radhika R. Gudi, Harrison Taylor, Benjamin M. Johnson, Ruchika Maurya, Mary E. Mulligan, Loni Carter, Caroline Westwater, Chenthamarakshan Vasu   +7 more
wiley   +1 more source

Faculty Opinions recommendation of High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis.

, 2019
Martine Bassilana
openalex   +1 more source

ALIX mediates reversible gasdermin-D pore formation via the endosomal pathway to limit pyroptosis by active membrane repair. [PDF]

Cell Death Dis
Otchere S, Shrestha P, Parmar HN, Perry JF, Hofmeister BL, Steyn M, Kaushik RS, Hoppe AD, Thiex NW, Hanson RL, Lopez-Mosqueda J, Imre G.   +11 more
europepmc   +1 more source

Proteome‐Guided Drug Target Discovery for Periodontitis

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Background and Objective Periodontitis is a chronic inflammatory disease driven by immune dysfunction and microbial imbalance. This study aims to identify circulating druggable proteins causally linked to the disease. Materials and Methods We integrated proteomics data from deCODE genetics with periodontitis genome‐wide association studies ...
Zoheir Alayash, Sebastian‐Edgar Baumeister, Birte Holtfreter, Thomas Kocher, Hansjörg Baurecht, Benjamin Ehmke, Daniel Hagenfeld, Stefan Lars Reckelkamm, Michael Nolde   +8 more
wiley   +1 more source

Tetrahydrocurcumin Protects Microglial Cells Against <i>Pseudomonas aeruginosa</i> Lipopolysaccharide-Induced Reactive Oxygen Species Production and Cathepsin B to Activate NLRP3 Inflammasome-Mediated Pyroptosis Via the HO-1 and p38/JNK Pathway. [PDF]

Int J Med Sci
Lin HW, Chen TC, Wang I, Yeh JH, Tsou SC, Sun L, Chung SC, Chuang CJ, Chang YY.   +8 more
europepmc   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Lipin3 deficiency promotes hepatocyte ferroptosis and pyroptosis via activating JAK1-STAT3 pathway during acetaminophen induced acute liver injury. [PDF]

Mol Biomed
Liu YX, Wang Q, Xiangyang ZY, Long JY, Huang H, Fan LL.   +5 more
europepmc   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

PANoptosis: A novel therapeutic target in kidney disease (Review). [PDF]

Int J Mol Med
Jiang L, Zhao L, Liu Y, Fu Z, Wu M, Mou Z, Li M.   +6 more
europepmc   +1 more source