Results 361 to 370 of about 82,547 (381)

Multifunctional Copper‐Phenolic Nanopills Achieve Comprehensive Polyamines Depletion to Provoke Enhanced Pyroptosis and Cuproptosis for Cancer Immunotherapy

Advances in Materials
The overexpression of polyamines in tumor cells contributes to the establishment of immunosuppressive microenvironment and facilitates tumor growth. Here, it have ingeniously designed multifunctional copper‐piceatannol/HA nanopills (Cu‐Pic/HA NPs) that ...
G. Zhu, Yulin Xie, Junrong Wang, Man Wang, Yanrong Qian, Qianqian Sun, Yunlu Dai, Chunxia Li   +7 more
semanticscholar   +1 more source

Catalytic Nanodots‐Driven Pyroptosis Suppression in Nucleus Pulposus for Antioxidant Intervention of Intervertebral Disc Degeneration

Advances in Materials
Low back pain resulting from intervertebral disc degeneration (IVDD) is a prevalent global concern; however, its underlying mechanism remains elusive. Single‐cell sequencing analyses revealed the critical involvement of pyroptosis in IVDD.
Kaiqiang Sun, Chen Yan, Xinyue Dai, Yangyang Shi, Fudong Li, Liang Chen, Jingchuan Sun, Yu Chen, Jiangang Shi   +8 more
semanticscholar   +1 more source

Thermal Proteome Profiling Strategy Identifies CNPY3 as a Cellular Target of Gambogic Acid for Inducing Prostate Cancer Pyroptosis.

Journal of Medicinal Chemistry
There is an urgent requirement to acquire a comprehensive comprehension of novel therapeutic targets for prostate cancer to facilitate the development of medications with innovative mechanisms.
Xiao-Wen Zhang, Ling Li, Min Liao, Dan Liu, Asma Rehman, Yang Liu, Zheng-Ping Liu, Peng-Fei Tu, Kewu Zeng   +8 more
semanticscholar   +1 more source

Nano‐Engineered Magnesium Implants for Magnetothermal Enhanced Pyroptosis to Boost Immunotherapy

Advanced Functional Materials
Hepatocellular carcinoma (HCC) is one of the leading contributors to cancer‐related death because the immunosuppressive tumor microenvironment (TME) limits its therapeutic efficacy. Gasdermin (GSDM)‐mediated pyroptosis is a new programmed cell death that
Xiao Han, Shumin Sun, Nailin Yang, Zhihui Han, Zifan Pei, Qiao Yu, Jihu Nie, L. Wang, Anhong Liu, Xiangxue Meng, Zhanhui Wang, Liang Cheng   +11 more
semanticscholar   +1 more source

Ferroptosis and Pyroptosis in Epilepsy

Molecular Neurobiology
Epilepsy is sudden, recurrent, and transient central nervous system dysfunction caused by abnormal discharge of neurons in the brain. Ferroptosis and pyroptosis are newly discovered ways of programmed cell death. One of the characteristics of ferroptosis is the oxidative stress generated by lipid peroxides.
Fan Feng, Rong Luo, Dezhi Mu, Qianyun Cai   +3 more
openaire   +2 more sources

Coral gasdermin triggers pyroptosis

Science Immunology, 2020
Coral gasdermin is activated by caspase 3 and involved in pathogen-induced coral death.
Shuai Jiang, Zhi Zhou, Yuanyuan Sun, Tengfei Zhang, Li Sun   +4 more
openaire   +3 more sources

Inflammasome-independent pyroptosis

Current Opinion in Immunology
Gasdermins are membrane pore-forming proteins that cause pyroptosis, an inflammatory cell death in which cells burst and release cytokines, chemokines, and other host alarm signals, such as ATP and HMGB1, which recruit and activate immune cells at sites of infection and danger. There are five gasdermins in humans - gasdermins A to E.
Xing, Liu, Judy, Lieberman
openaire   +2 more sources

"Multi-in-One" Yolk-Shell Structured Nanoplatform Inducing Pyroptosis and Antitumor Immune Response Through Cascade Reactions.

Small
Pyroptosis, a new mode of regulatory cell death, holds a promising prospect in tumor therapy. The occurrence of pyroptosis can trigger the release of damage-associated molecular patterns (DAMPs) and activate the antitumor immune response.
Yuying Wang, Shulan Li, Xiaoyang Zhang, F. Jiang, Qing-Lian Guo, Peng Jiang, Yi Liu   +6 more
semanticscholar   +1 more source

Pyroptosis heats tumour immunity

Nature Reviews Immunology, 2020
Two studies published in Nature report that gasdermin-mediated pyroptosis of tumour cells induces cytotoxic lymphocyte-mediated antitumour immune responses.
openaire   +3 more sources

Destroying tumors with pyroptosis

Science Signaling, 2020
Gasdermin E suppresses tumor growth by stimulating antitumor immunity in a pyroptosis-dependent manner.
openaire   +2 more sources