Results 361 to 370 of about 77,046 (386)

Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models

Science Translational Medicine, 2023
Pancreatic and lung cancers frequently develop resistance to chemotherapy-induced cell apoptosis during the treatment, indicating that targeting nonapoptotic-related pathways, such as pyroptosis, can be an alternative cancer treatment strategy ...
Liangping Su, Yitian Chen, Cheng Huang, Sangqing Wu, Xiaojuan Wang, Xinbao Zhao, Qiuping Xu, Ruipu Sun, Xiangzhan Kong, Xue Jiang, Xiaoyi Qiu, Xiaoming Huang, Minghui Wang, Ping-Pui Wong   +13 more
semanticscholar   +1 more source

Photon-Controlled Pyroptosis Activation (PhotoPyro): An Emerging Trigger for Antitumor Immune Response.

Journal of the American Chemical Society, 2023
Pyroptosis refers to the process of gasdermin-mediated lytic programmed cell death (PCD) characterized by the release of pro-inflammatory cytokines.
Mingle Li, Jungryun Kim, H. Rha, Subin Son, Matthew S Levine, Yunjie Xu, J. Sessler, Jong Seung Kim   +7 more
semanticscholar   +1 more source

Molecular Mechanisms of Pyroptosis

2023
Pyroptosis is a regulated form of cell death that leads to inflammation and plays a role in many different diseases. Pyroptosis was initially defined by the dependence on caspase-1, a protease which is activated by innate immune signaling complexes called inflammasomes.
Marisa J, Anderson, Andreas B, den Hartigh, Susan L, Fink   +2 more
openaire   +2 more sources

The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis

Science immunology
Plasma membrane perforation elicited by caspase cleavage of the gasdermin D (GSDMD) N-terminal domain (GSDMD-NT) triggers pyroptosis. The mechanisms underlying GSDMD membrane translocation and pore formation are not fully understood.
A. Balasubramanian, A. Hsu, Laxman Ghimire, Muhammad Tahir, Pascal Devant, Pietro Fontana, Gang Du, Xing Liu, Dang Fabin, Hiroto Kambara, Xuemei Xie, Fei Liu, Tomoya Hasegawa, Rong Xu, H. Yu, Mei Chen, Steven Kolakowski, S. Trauger, M. R. Larsen, Wenyi Wei, Haoying Wu, Jonathan C. Kagan, Judy Lieberman, H. Luo   +23 more
semanticscholar   +1 more source

A checkpoint for pyroptosis

Science Signaling, 2020
The nuclear pool of an immune checkpoint protein promotes pyroptosis and tumor necrosis downstream of TNFα.
openaire   +2 more sources

Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism.

Angewandte Chemie, 2023
Although immunotherapy has a broad clinical application prospect, it is still hindered by low immune responses and immunosuppressive tumor microenvironment.
Binbin Ding, Pan Zheng, Jia Tan, Hao Chen, Qi Meng, Jing Li, Xinyang Li, Di Han, Ziyao Li, Xinyu Ma, Ping'an Ma, Jun Lin   +11 more
semanticscholar   +1 more source

Platinum Prodrug Nanoparticles with COX‐2 Inhibition Amplify Pyroptosis for Enhanced Chemotherapy and Immune Activation of Pancreatic Cancer

Advances in Materials, 2023
Pyroptosis, an emerging mechanism of programmed cell death, holds great potential to trigger a robust antitumor immune response. Platinum‐based chemotherapeutic agents can induce pyroptosis via caspase‐3 activation.
Bingzheng Yu, Yushu Wang, Tiejun Bing, Yujing Tang, Jia Huang, Haihua Xiao, Chaoyong Liu, Yingjie Yu   +7 more
semanticscholar   +1 more source

Catalytic Nanodots‐Driven Pyroptosis Suppression in Nucleus Pulposus for Antioxidant Intervention of Intervertebral Disc Degeneration

Advances in Materials
Low back pain resulting from intervertebral disc degeneration (IVDD) is a prevalent global concern; however, its underlying mechanism remains elusive. Single‐cell sequencing analyses revealed the critical involvement of pyroptosis in IVDD.
Kaiqiang Sun, Chen Yan, Xinyue Dai, Yangyang Shi, Fudong Li, Liang Chen, Jingchuan Sun, Yu Chen, Jiangang Shi   +8 more
semanticscholar   +1 more source

Nanodrug Augmenting Antitumor Immunity for Enhanced TNBC Therapy via Pyroptosis and cGAS-STING Activation.

Nano letters (Print), 2023
Pyroptosis is a proinflammatory form of programmed cell death that results in the release of cellular contents and activation of immune responses. However, GSDME (a pyroptosis-executed protein) is suppressed in many cancers.
Huihai Zhong, Gengjia Chen, Tan Li, Jinsheng Huang, Minzhao Lin, Bo Li, Zecong Xiao, X. Shuai   +7 more
semanticscholar   +1 more source

Thermal Proteome Profiling Strategy Identifies CNPY3 as a Cellular Target of Gambogic Acid for Inducing Prostate Cancer Pyroptosis.

Journal of Medicinal Chemistry
There is an urgent requirement to acquire a comprehensive comprehension of novel therapeutic targets for prostate cancer to facilitate the development of medications with innovative mechanisms.
Xiao-Wen Zhang, Ling Li, Min Liao, Dan Liu, Asma Rehman, Yang Liu, Zheng-Ping Liu, Peng-Fei Tu, Kewu Zeng   +8 more
semanticscholar   +1 more source