Results 191 to 200 of about 105,049 (336)

Selective N‐Functionalization of Pyrazoles

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek   +2 more
wiley   +1 more source

Navigating the Radical Oxo‐Functionalization of Alkenes Toward Ketones

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
Straightforward access to complex ketones in a single synthetic step: This Review surveys the latest advances in three‐component alkene 1,2‐oxo‐functionalizations. The opportunities unlocked by the so‐called single‐electron (1e–) logic, including access to a broad pool of radical precursors and carbonyl oxygen atom sources, are highlighted.
Mattia Lepori   +3 more
wiley   +1 more source

Click Bioconjugation of Aza‐BODIPY Fluorophores to LfcinB Peptides for Improved Biocompatibility

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
Click bioconjugation attaches NIR aza‐BODIPY fluorophores to LfcinB‐derived anticancer peptides via CuAAC and thiol‐maleimide chemistry. Conjugates exhibit improved predicted solubility while retaining strong NIR absorption (703–730 nm). Peptide‐aza‐BODIPY conjugates induce apoptotic morphology in HeLa cancer cells.
A. Verónica Rodríguez‐Mayor   +6 more
wiley   +1 more source

Photocatalysis‐Triggered Click Reactions and Applications

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
Photoclick chemistry offers broad applications ranging from materials science to bioconjugation, with precise spatiotemporal control over click reactions. Initially limited to UV activation, recent advances have extended photoclick processes to the visible and NIR regions thanks to the photocatalysis.
Margaux Walter   +2 more
wiley   +1 more source

Photochromism of Dicyanorhodanine-Pyrrole Conjugates: Substituent and Solvent Effects. [PDF]

open access: yesACS Omega
Das P   +4 more
europepmc   +1 more source

Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics

open access: yes, 2015
Varun Bhardwaj   +4 more
semanticscholar   +1 more source

Bromonitroalkanes in Organic Synthesis

open access: yesEuropean Journal of Organic Chemistry, EarlyView.
α,α‐Bromonitroalkanes (BNAs) exhibit chameleon‐like reactivity, serving as carbene, radical, carbanion, and carbocation synthons. This mini‐review summarizes the different reaction modes and highlights recent developments in thermal and photochemical processes. α,α‐Bromonitroalkanes (BNAs) exhibit chameleon‐like reactivity, serving as carbene, radical,
Magdalena Koch, Oliver Reiser
wiley   +1 more source

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