Pyrrolidine Dithiocarbamate prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats [PDF]
Frontiers in Aging Neuroscience, 2016 Systemic inflammation, for example as a result of infection, often contributes to long-term complications. Neuroinflammation and cognitive decline are key hallmarks of several neurological conditions, including advance age.
Min Hui Kan +6 more
doaj +7 more sources
Pyrrolidine Dithiocarbamate Suppresses Cutibacterium acnes-Induced Skin Inflammation. [PDF]
Int J Mol Sci, 2023 Cutibacterium acnes (C. acnes), a Gram-positive anaerobic bacterium, proliferates in hair follicles and pores and causes inflammation in the skin of young people. The rapid growth of C.
Shin JH, Kim SS, Seo SR.
europepmc +6 more sources
Pyrrolidine dithiocarbamate administered during ex-vivo lung perfusion promotes rehabilitation of injured donor rat lungs obtained after prolonged warm ischemia. [PDF]
PLoS One, 2017 Damaged lung grafts obtained after circulatory death (DCD lungs) and warm ischemia may be at high risk of reperfusion injury after transplantation. Such lungs could be pharmacologically reconditioned using ex-vivo lung perfusion (EVLP).
Francioli C +11 more
europepmc +7 more sources
Bidirectional Effects of Pyrrolidine Dithiocarbamate on Severe Acute Pancreatitis in a Rat Model [PDF]
Dose-Response, 2019 Introduction: The mechanism by which intestinal mucosal barrier is damaged in severe acute pancreatitis (SAP)-associated impairment is not fully understood.
Huan Yang +4 more
doaj +5 more sources
Pyrrolidine Dithiocarbamate Might Mitigate Radiation-Induced Heart Damage at an Early Stage in Rats [PDF]
Frontiers in Pharmacology, 2022 Objective: Radiation-induced heart damage (RIHD) is becoming an increasing concern due to offsetting clinical benefits of radiotherapy to a certain extent.
Yajing Wu +7 more
doaj +3 more sources
Ammonium Pyrrolidine Dithiocarbamate-Modified CdTe/CdS Quantum Dots as a Turn-on Fluorescent Sensor for Detection of Trace Cadmium Ions [PDF]
Sensors, 2020 In this work, ammonium pyrrolidine dithiocarbamate (APDC) was used as a surface etchant to modify CdTe/CdS core-shell quantum dots (QDs). The APDC etchant combines with the cadmium ions (Cd2+) on the surface of the QDs, resulting in the formation of ...
Yuan Yin, Qingliang Yang, Gang Liu
doaj +3 more sources
Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis [PDF]
Frontiers in Pharmacology, 2017 Cancer cachexia is a kind of whole body metabolic disorder syndrome accompanied with severe wasting of muscle and adipose tissue. NF-κB signaling plays an important role during skeletal muscle atrophy and fat lipolysis. As an inhibitor of NF-κB signaling,
Chunxiao Miao +9 more
doaj +3 more sources
Pyrrolidine Dithiocarbamate Facilitates Arsenic Trioxide Against Pancreatic Cancer via Perturbing Ubiquitin-Proteasome Pathway [PDF]
Cancer Management and Research, 2020 Simin Yu,1,* Ning Wu,2,* Jianmin Zhu,3 Ying Liu,4 Jinbin Han1 1Department of Traditional Chinese Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department ...
Yu S, Wu N, Zhu J, Liu Y, Han J
doaj +4 more sources
Pyrrolidine dithiocarbamate ameliorates endothelial dysfunction in thoracic aorta of diabetic rats by preserving vascular DDAH activity. [PDF]
PLoS ONE, 2017 Endothelial dysfunction plays a pivotal role in the development of diabetic cardiovascular complications. Accumulation of endogenous nitric oxide synthase (NOS) inhibitor asymmetric dimethylarginine (ADMA) and inhibition of dimethylarginine ...
Chang-Wu Lu +5 more
doaj +3 more sources
Pyrrolidine dithiocarbamate reduces the progression of total kidney volume and cyst enlargement in experimental polycystic kidney disease. [PDF]
Physiol Rep, 2014 Heterocyclic dithiocarbamates have anti‐inflammatory and anti‐proliferative effects in rodent models of chronic kidney disease. In this study, we tested the hypothesis that pyrrolidine dithiocarbamate (PDTC) reduces the progression of polycystic kidney ...
Ta MH +6 more
europepmc +4 more sources