Results 101 to 110 of about 39,221 (244)

Camptothecin induces urokinase-type plasminogen activator gene-expression in human RC-K8 malignant lymphoma and H69 small cell lung cancer cells. [PDF]

, 2002
We previously reported that anthracyclines, which could generate reactive oxygen species (ROS), could induce the urokinase-type plasminogen activator (uPA) gene expression in human RC-K8 malignant lymphoma cells and in H69 small cell lung cancer (SCLC ...
Kiguchi, Toru, Nakata, Yasunari, Niiya, Kenji, Shibakura, Misako, Tanimoto, Mitsune   +4 more
core   +1 more source

Decoding the Implications of Zinc in the Development and Therapy of Leukemia

Advanced Science, Volume 12, Issue 9, March 6, 2025.
Zinc's pivotal role in hematological development and its therapeutic potential in leukemia are explored. This review delves into the complex interplay of zinc signaling in leukemia progression and treatment. It highlights recent advancements, such as zinc's regulation of ferroptosis and its impact on immunotherapy, underscoring the need for zinc‐based ...
Bo Zhu, Chunhao Yang, Siqi Hua, Kaiqiang Li, Pengyou Shang, Zhonghua Li, Wei Qian, Shunkang Xue, Qi Zhi, Zichun Hua   +9 more
wiley   +1 more source

μ3-Chlorido-μ2-chlorido-(μ3-pyrrolidine-1-carbodithioato-κ4S:S,S′:S′)tris[(triethylphosphane-κP)copper(I)]: crystal structure and Hirshfeld surface analysis

Acta Crystallographica Section E: Crystallographic Communications, 2017
The title trinuclear compound, [Cu3(C5H8NS2)Cl2(C6H15P)3], has the dithiocarbamate ligand symmetrically chelating one CuI atom and each of the S atoms bridging to another CuI atom.
Yi Jiun Tan, Chien Ing Yeo, Nathan R. Halcovitch, Mukesh M. Jotani, Edward R. T. Tiekink   +4 more
doaj   +1 more source

Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells [PDF]

, 2015
BACKGROUND: Dexamethasone suppressed inflammation and haemodynamic changes in an animal model of pulmonary arterial hypertension (PAH). A major target for dexamethasone actions is NF-κB, which is activated in pulmonary vascular cells and perivascular ...
Adcock, IM, Dorfmuller, P, Garfield, BE, Humbert, M, Meng, C, Montani, D, Perros, F, Price, LC, Shao, D, Wort, SJ, Zhu, J   +10 more
core   +2 more sources

Exploring Punicalagin Potential Against Cancers: A Comprehensive Review

Food Science &Nutrition, Volume 13, Issue 3, March 2025.
This paper focuses on highlighting the therapeutic potential of punicalagin against tumors and cancers. Punicalagin inhibits tumor growth within the body through various cellular pathway interactions. This compound has efficacy in eliminating tumor cells from the liver, stomach, prostate, and lungs.
Muhammad Hammad Ul Hassan, Muhammad Shahbaz, Ushna Momal, Hammad Naeem, Muhammad Imran, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Ehab M. Mostafa, Ahmed H. El‐Ghorab, Suliman A. Alsagaby, Waleed Al Abdulmonem, Muzzamal Hussain, Tadesse Fenta Yehuala   +12 more
wiley   +1 more source

Spinal NF-κB and chemokine ligand 5 expression during spinal glial cell activation in a neuropathic pain model. [PDF]

PLoS ONE, 2015
BACKGROUND:The NF-κB pathway and chemokine (C-C motif) ligand 5 (CCL5) are involved in pain modulation; however, the precise mechanisms of their interactions in chronic neuropathic pain have yet to be established.
Qin Yin, Qin Fan, Yu Zhao, Ming-Yue Cheng, He Liu, Jing Li, Fei-Fei Lu, Jin-Tai Jia, Wei Cheng, Chang-Dong Yan   +9 more
doaj   +1 more source

Synthesis, Characterization, and Biological Activity of Nickel (II) and Palladium (II) Complex with Pyrrolidine Dithiocarbamate (PDTC)

, 2016
The synthesis of square planar Ni(II) and Pd(II) complexes with pyrrolidine dithiocarbamate (PDTC) was characterized by elemental, physiochemical, and spectroscopic methods.
S. Islam, Suvendu Das, S. Chakrabarty, S. Hazra, A. Pandey, Animesh Patra   +5 more
semanticscholar   +1 more source

Therapeutic Potential of Gasdermin D‐Mediated Myocardial Pyroptosis in Ischaemic Heart Disease: Expanding the Paradigm From Bench to Clinical Insights

Journal of Cellular and Molecular Medicine, Volume 29, Issue 3, February 2025.
ABSTRACT Ischaemic heart disease (IHD) remains a leading cause of global morbidity and mortality. One significant contributor to the pathology of IHD is the excessive release of inflammatory mediators during the disease progression. Pyroptosis is a form of programmed cell death (PCD) triggered by the activation of inflammasomes and caspase 1.
Chanon Piamsiri, Chayodom Maneechote, Siriporn C. Chattipakorn, Nipon Chattipakorn   +3 more
wiley   +1 more source

Crocin Protects Podocytes Against Oxidative Stress and Inflammation Induced by High Glucose Through Inhibition of NF-κB

Cellular Physiology and Biochemistry, 2017
Background/Aims: Diabetic nephropathy (DN) is a microangiopathic disease characterized by excessive urinary albumin excretion, which occurs in 30% of patients with diabetes mellitus.
Sutong Li, Xiaoxia Liu, Jie Lei, Junle Yang, Puxun Tian, Yi Gao   +5 more
doaj   +1 more source

Inhibition of ASIC1a reduces ferroptosis in rheumatoid arthritis articular chondrocytes via the p53/NRF2/SLC7A11 pathway

The FASEB Journal, Volume 39, Issue 1, 15 January 2025.
Schematic representation of the molecular mechanism of ferroptosis induced by ASIC1a in chondrocytes. ASIC1a mediates Ca2+ influx, activating the p53/NRF2/SLC7A11 pathway and Fe2+ accumulation, thereby inducing ferroptosis in chondrocytes. Abstract The activation of acid‐sensing ion channel 1a (ASIC1a) in response to extracellular acidification leads ...
Jie Tang, Wenqiang Liu, Zihan Li, Can Shen, Longbiao Zhang, Cheng Wang, Fengshuo Wang, Zhuoyan Zai, Xuewen Qian, Weirong Hu, Xiaoyue Zhang, Xiaoqing Peng, Yayun Xu, Feihu Chen   +13 more
wiley   +1 more source