Results 111 to 120 of about 39,221 (244)

Cathepsin K Deficiency Reduces Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice [PDF]

, 2011
Objective: Cathepsin K (CatK) is one of the most potent mammalian elastases. We have previously shown increased expression of CatK in human abdominal aortic aneurysm (AAA) lesions.
Chen, Han, Gelb, Bruce D., Libby, Peter, Shi, Guo-Ping, Sjoberg, Sara, Sukhova, Galina K., Sun, Jiusong, Xia, Mingcan, Xiong, Na, Zhang, Jie   +9 more
core   +2 more sources

PDPN+ cancer‐associated fibroblasts enhance gastric cancer angiogenesis via AKT/NF‐κB activation and the CCL2‐ACKR1 axis

MedComm, Volume 6, Issue 1, January 2025.
The Akt/NF‐κB pathway was significantly activated in podoplanin (PDPN)(+) cancer‐associated fibroblasts (CAFs). P65 directly bind to the chemokine (CC‐motif) ligand 2 (CCL2) promoter, thereby increasing the CCL2 transcription and secretion in CAFs; CCL2, which was transcriptional activated by P65 in PDPN(+) CAFs, sustains tumor angiogenesis by ...
Zhenxiong Zhao, Hui Sun, Yingxue Liu, Yanqiu Zhang, Xin Wang, Xu Wang, Cong Tan, Shujuan Ni, Weiwei Weng, Meng Zhang, Lei Wang, Dan Huang, Wenchao Gu, Jinjia Chang, Weiqi Sheng, Mi‐die Xu   +15 more
wiley   +1 more source

Molecular mechanisms of IL-18BP regulation in DLD-1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level [PDF]

, 2008
Interleukin (IL)-18, formerly known as interferon (IFN)-γ-inducing factor, is a crucial mediator of host defence and inflammation. Control of IL-18 bioactivity by its endogenous antagonist IL-18 binding protein (IL-18BP) is a major objective of ...
Bachmann, Malte, Mühl, Heiko, Paulukat, Jens, Pfeilschifter, Josef Martin   +3 more
core   +1 more source

Unveiling VCAM‐1’s Multifaceted Role in Secondary Diabetic Complications

Journal of Food Quality, Volume 2025, Issue 1, 2025.
Diabetes mellitus is a chronic metabolic disorder characterized by sustained hyperglycemia, tightly interlinked with a range of severe secondary complications. Diabetic retinopathy, nephropathy, and cardiomyopathy substantially contribute to the overall morbidity and mortality associated with diabetes.
Prabhnain Kaur, Ritu, Kalicharan Sharma, Ramesh K. Goyal, Parakh Basist, Rahmuddin Khan, Abdulsalam Alhalmi, Mohamed Addi   +7 more
wiley   +1 more source

PTPIP51—A New RelA-tionship with the NFκB Signaling Pathway

Biomolecules, 2015
The present study shows a new connection of protein tyrosine phosphatase interacting protein 51 (PTPIP51) to the nuclear factor κB (NFκB) signalling pathway. PTPIP51 mRNA and protein expression is regulated by RelA. If bound to the PTPIP51 promoter, RelA
Alexander Brobeil, Fabian Kämmerer, Claudia Tag, Klaus Steger, Stefan Gattenlöhner, Monika Wimmer   +5 more
doaj   +1 more source

7-Ketocholesterol Induces Cell Apoptosis by Activation of Nuclear Factor kappa B in Mouse Macrophages [PDF]

, 2010
We investigated the molecular mechanisms responsible for the induction of apoptosis in mouse monocytic macrophage cell line J774A.1 stimulated by 7-ketocholesterol (7-KC). Cell apoptosis was detected by Annexin V-propidium iodide (PI) staining.
Chi, Yan, Huang, Zhenyu, Li, Wenzhe, Liu, Qingping, Liu, Zhe, Liu, Zibo, Matsuura, Eiji, Wang, Dan, Wang, Renjun, Zhang, Fan, Zhang, Qiming, Zhang, Yingbiao   +11 more
core   +1 more source

Ex Vivo Organ Perfusion Systems for Disease Modeling and Therapeutic Applications in Small Animal Models

Journal of Tissue Engineering and Regenerative Medicine, Volume 2025, Issue 1, 2025.
Ex vivo organ perfusion (EVOP) is used for whole organ preservation, and the main focus is to improve the outcome of donor organs for transplantation. Recently, EVOP has found application in disease modeling, drug development, and tissue regeneration. We discuss progress in EVOP research involving small animal organs using benchtop and incubator‐based ...
Mina Yeganeh, Andea Zito, Marwa Sadat, Agostino Pierro, Ian M. Rogers, Cherie Stabler   +5 more
wiley   +1 more source

Analytical methods for mercury speciation in several matrixes: a review [PDF]

, 2008
Mercury is one of the hazardous contaminants that may be present in the environment. Moreover, its toxicological effects are strongly dependent on the chemical form of the element, being the organic species the most toxic.
Ramalhosa, Elsa, Río-Segade, Susana
core  

Efficient execution of cell death in non-glycolytic cells requires the generation of ROS controlled by the activity of mitochondrial H+-ATP synthase [PDF]

, 2005
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Carcinogenesis following peer review. The definitive publisher-authenticated version Carcinogenesis 2006 27(5):925-935 is available at: http://dx.doi.org/10.1093 ...
Cuezva, José M., Fabregat, Isabel, Martínez-Díez, Marta, Santamaría, Gema   +3 more
core   +1 more source

Cerebral vascular malformations: pathogenesis and therapy

MedComm, Volume 5, Issue 12, December 2024.
CVMs management based on imaging genomics and liquid biopsy. In the future, somatic or de novo germline mutation information could be used to direct neurosurgical and medical management of CVMs. Somatic or germline variants can be acquired from imaging genomics or liquid biopsies preoperatively.
Qiheng He, Ran Huo, Yingfan Sun, Zhiyao Zheng, Hongyuan Xu, Shaozhi Zhao, Yang Ni, Qifeng Yu, Yuming Jiao, Wenqian Zhang, Jizong Zhao, Yong Cao   +11 more
wiley   +1 more source