Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. [PDF]
J Neuroinflammation, 2016 BackgroundEndogenous defense against oxidative stress is controlled by nuclear factor erythroid 2-related factor 2 (Nrf2). The normal compensatory mechanisms to combat oxidative stress appear to be insufficient to protect against the prolonged exposure ...
Liddell JR +9 more
europepmc +7 more sources
Pyrrolidine dithiocarbamate and saxagliptin ameliorate ulcerative colitis in rats
Asian Pacific Journal of Tropical Biomedicine, 2019 Objective: To evaluate the antioxidant, immunomodulatory and anti-inflammatory activities of pyrrolidine dithiocarbamate and saxagliptin in rats with thioacetamide-induced ulcerative colitis.
Berween Mahmoud Elmahmoudy +3 more
doaj +3 more sources
Therapeutic effects of pyrrolidine dithiocarbamate on acute lung injury in rabbits [PDF]
Journal of Translational Medicine, 2011 Background Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is an early characteristic of multiple organ dysfunction, responsible for high mortality and poor prognosis in patients.
Wang Xiangdong +5 more
doaj +5 more sources
Pyrrolidine Dithiocarbamate Inhibits Nuclear Factor κB and Toll-Like Receptor 4 Expression in Rats with Acute Necrotizing Pancreatitis [PDF]
Gut and Liver, 2015 Background/AimsTo investigate the expression of Toll-like receptor 4 (TLR4) in the pancreases of rats with acute necrotizing pancreatitis (ANP) and any changes upon treatment with pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor κB (NF ...
Xu M, Wang KN, Wu K, Wang XP.
doaj +3 more sources
Pyrrolidine dithiocarbamate (PDTC) inhibits the overexpression of MCP-1 and attenuates microglial activation in the hippocampus of a pilocarpine-induced status epilepticus rat model. [PDF]
Exp Ther Med, 2014 The aim of this study was to investigate the effects of pyrrolidine dithiocarbamate (PDTC) on MCP-1 expression and microglial activation in the hippocampus of a rat model of pilocarpine (PILO)-induced status epilepticus (SE).
Lv R +5 more
europepmc +4 more sources
Compression of curium pyrrolidine-dithiocarbamate enhances covalency
Nature, 2020 Curium is unique in the actinide series because its half-filled 5f 7 shell has lower energy than other 5f n configurations, rendering it both redox-inactive and resistant to forming chemical bonds that engage the 5f shell1-3. This is even more pronounced in gadolinium, curium's lanthanide analogue, owing to the contraction of the 4f orbitals with ...
Joseph M. Sperling +18 more
semanticscholar +5 more sources
Regulatory mechanism of pyrrolidine dithiocarbamate is mediated by nuclear factor-κB and inhibits neutrophil accumulation in ARDS mice. [PDF]
Exp Ther Med, 2014 The aim of the present study was to investigate the regulatory mechanism of nuclear factor (NF)-κB on polymorphonuclear neutrophil (PMN) accumulation and the inflammatory response in lung tissues with acute respiratory distress syndrome (ARDS), as well ...
Wang H +9 more
europepmc +4 more sources
Pyrrolidine Dithiocarbamate Attenuates Cardiocyte Apoptosis and Ameliorates Heart Failure Following Coronary Microembolization in Rats [PDF]
Balkan Medical Journal, 2019 Background: Nuclear factor-kB is highly activated in cardiovascular disorders. However, few articles have targeted at the role of nuclear factor-kB inhibitor in heart failure.
Shumei Li, Jun Fang, Lianglong Chen
doaj +2 more sources
Pyrrolidine Dithiocarbamate (PDTC) Inhibits DON-Induced Mitochondrial Dysfunction and Apoptosis via the NF-κB/iNOS Pathway. [PDF]
Oxid Med Cell Longev, 2018 Oxidative stress is closely linked to the toxic responses of various cell types in normal and pathophysiological conditions. Deoxynivalenol (DON), an inducer of stress responses in the ribosome and the endoplasmic reticulum (ER), causes mitochondrial ...
Wan D, Wu Q, Qu W, Liu G, Wang X.
europepmc +2 more sources
The possible protective effect of the nuclear factor kappa B inhibitor pyrrolidine dithiocarbamate on tramadol-induced testicular damage in rats [PDF]
Egyptian Journal of Forensic Sciences, 2023 Background Tramadol provokes oxidative stress that gives rise to apoptosis with alterations in the cellular structure and adversely influences male fertility. A specific inhibitor of nuclear factor kappa B (NF-κB), pyrrolidine dithiocarbamate (PDTC), has
Abeer Ramzy Hussieny Mahmoud +4 more
doaj +2 more sources