Results 211 to 220 of about 39,221 (244)

PYRROLIDINE DITHIOCARBAMATE REDUCED SPINAL CORD TRAUMA IN RATS

Shock, 2004
Recent studies have demonstrated that NF-kappaB and oxidative stress contributes to secondary injury after impacted injury to the rat spinal cord. We postulated that pyrrolidine dithiocarbamate (PDTC), antioxidant which is potent inhibitor of NF-kappaB, would attenuate NF-kappaB-related inflammatory and oxidative events which occur after spinal cord ...
GENOVESE, TIZIANA, CARDALI, Salvatore Massimiliano, CONTI, Alfredo, DI PAOLA R, CUZZOCREA, Salvatore   +4 more
openaire   +5 more sources

Copper(II) complexes of pyrrolidine dithiocarbamate

Transition Metal Chemistry, 2006
Copper(II)-pyrrolidine dithiocarbamate (PDTC) complexes having the general formula, [Cu(PDTC)2], [Cu(PDTC)X2]− (where X = Cl−, I−, CN−, SCN−) and [Cu(PDTC)(en)]+ (en = ethylenediamine) have been prepared and characterized by IR spectroscopy and by thermogravimetric analysis (TGA and DTA).
Masood Sarwar, Saeed Ahmad, Sajjad Ahmad, Saqib Ali, Shafique Ahmed Awan   +4 more
openaire   +1 more source

Topical emulsion containing pyrrolidine dithiocarbamate: effectiveness against ultraviolet B irradiation‐induced injury of hairless mouse skin

The Journal of pharmacy and pharmacology, 2018
To evaluate the effects of a topical emulsion containing pyrrolidine dithiocarbamate (PDTC) (EcPDTC) in skin oxidative stress and inflammation triggered by ultraviolet B (UVB) irradiation (dose of 4.14 J/cm2).
Renata M. Martinez, Ana L. M. Ivan, D. L. Vale, M. Z. Campanini, Vitor S Ferreira, Vinicius S Steffen, F. Vicentini, F. M. P. Vilela, M. Fonseca, M. Baracat, S. Georgetti, W. Verri, R. Casagrande   +12 more
semanticscholar   +1 more source

Pyrrolidine Dithiocarbamate Attenuates Endotoxin-induced Acute Lung Injury

American Journal of Respiratory Cell and Molecular Biology, 1997
Lung injury in the acute respiratory distress syndrome (ARDS) is in part due to polymorphonuclear leukocyte (PMN)-mediated oxidative tissue damage. By means of nuclear factor-kappaB (NF-kappaB) activation, oxidants may also induce several genes implicated in the inflammatory response. The dithiocarbamates are antioxidants with potent inhibitory effects
A B, Nathens, R, Bitar, C, Davreux, M, Bujard, J C, Marshall, A P, Dackiw, R W, Watson, O D, Rotstein   +7 more
openaire   +2 more sources

Pyrrolidine dithiocarbamate protects against scopolamine-induced cognitive impairment in rats.

European Journal of Pharmacology, 2014
Alzheimer's disease (AD) is a chronic neurodegenerative disorder that leads to disturbances of cognitive functions. Although the primary cause of AD remains unclear, brain acetylcholine deficiency, oxidative stress and neuroinflammation may be considered the principal pathogenic factors.
Mai A Abd-El-Fattah, Noha F Abdelakader, Hala F Zaki   +2 more
semanticscholar   +3 more sources

Therapy of experimental influenza virus infection with pyrrolidine dithiocarbamate

Medical Microbiology and Immunology, 2010
The search for new antiviral strategies to treat influenza A virus (IAV) infections is one major international health care activity. Hereby, the IAV-caused misuse of cellular nuclear factor kappa B (NF-κB) signaling pathways in infected cells represents one target for antiviral therapy. In the present study, pyrrolidine dithiocarbamate (PDTC), which is
Nadine, Wiesener, Christin, Zimmer, Nadine, Jarasch-Althof, Peter, Wutzler, Andreas, Henke   +4 more
openaire   +2 more sources

Pyrrolidine Dithiocarbamate Induces Apoptosis by a Cytochrome c-Dependent Mechanism

Biochemical and Biophysical Research Communications, 2000
Pyrrolidine dithiocarbamate (PDTC) is a synthetic antioxidant molecule, which has been recently proposed as an antitumoral agent on the basis of its capability of inducing apoptosis. We investigated the effect of PDTC on the proliferation and survival of the promyelocitic cell line HL-60.
DELLA RAGIONE, Fulvio, CUCCIOLLA V, BORRIELLO, Adriana, DELLA PIETRA V, MANNA, Caterina, GALLETTI P, ZAPPIA V.   +6 more
openaire   +3 more sources

Pyrrolidine Dithiocarbamate Reduces the Severity of Cerulein-Induced Murine Acute Pancreatitis

Shock, 2003
The nuclear factor-kappaB (NF-kappaB) is a transcription factor that plays a pivotal role in the induction of genes involved in the response to injury and inflammation. Dithiocarbamates are antioxidants that are potent inhibitors of NF-kappaB. This study tested the hypothesis that pyrrolidine dithiocarbamate (PDTC) attenuates experimental acute ...
VIRLOS L, MAZZON E, SERRAINO I, DI PAOLA R, GENOVESE T, BRITTI D, THIEMERMANN C, SIRIWARDENA A, CUZZOCREA, Salvatore, DI PAOLA, ROSANNA   +9 more
openaire   +3 more sources

Synergistic Effect of Pyrrolidine Dithiocarbamate and Cisplatin in Human Cervical Carcinoma

Reproductive Sciences, 2014
We aimed to delineate how pyrrolidine dithiocarbamate (PDTC) affects nuclear factor κB (NF-κB) and to determine its antitumor activity alone and in combination with cisplatin in human cervical cancer SiHa cells. The SiHa cells were treated with various concentrations of PDTC and/or cisplatin at various time intervals.
Xiao-qun Zheng, Jieqiang Lv, Q. Shen, Yumei Chen, Qingfeng Zhou, Wenwen Zhang, Xueqiong Zhu   +6 more
semanticscholar   +3 more sources

Pyrrolidine Dithiocarbamate-loaded Electrospun Membranes for Peritendinous Anti-adhesion through Inhibition of the Nuclear Factor-κB Pathway.

Acta Biomaterialia, 2022
Mingkuan Lu, Shuo Wang, Hui Wang, Tong Xue, Chuandong Cai, C. Fan, Fei Wu, Shen Liu   +7 more
semanticscholar   +1 more source