Results 221 to 230 of about 39,221 (244)

Pyrrolidine dithiocarbamate protects against thioacetamide-induced fulminant hepatic failure in rats

Journal of Hepatology, 2002
Reactive oxygen species and nuclear factor kappa B (NF-kappaB) activation have been implicated in the pathogenesis of cell injury in experimental models of liver damage. The aim of the present study was to examine whether pyrrolidine dithiocarbamate (PDTC), an anti oxidant and inhibitor of NF-kappaB activation, would prevent hepatic damage induced in a
Rafael, Bruck, Hussein, Aeed, Ron, Schey, Zipora, Matas, Ram, Reifen, Gidi, Zaiger, Ayala, Hochman, Yona, Avni   +7 more
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Potentiation of bacterial killing activity of zinc chloride by pyrrolidine dithiocarbamate

The Journal of Microbiology, 2010
Zinc has antimicrobial activity and zinc salts including zinc chloride (ZnCl(2)) have been used for the control of oral malodor. In this study, we hypothesized that pyrrolidine dithiocarbamate (PDTC), a zinc ionophore, may enhance antimicrobial efficacy of ZnCl(2).
Eun-Kyoung, Choi, Hye-Hyang, Lee, Mi-Sun, Kang, Byung-Gook, Kim, Hoi-Soon, Lim, Seon-Mi, Kim, In-Chol, Kang   +6 more
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Pyrrolidine dithiocarbamate improves mortality in a rat model of severe hemorrhage

Journal of Surgical Research, 2013
Hemorrhagic shock is a life threatening condition characterized by diminishing organ function. The aim of this study was to determine whether an effective pyrrolidine dithiocarbamate (PDTC) treatment protocol could be established to decrease organ dysfunction and mortality in a lethal hemorrhagic shock-resuscitation (HSR) model.Sprague-Dawley rats were
Anna E, Montegudo, Mary A, Palilonis, Cathy C, Moore, Toan, Huynh, Iain H, McKillop, Susan L, Evans   +5 more
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Effects of Pyrrolidine dithiocarbamate on apoptosis

2007
Pyrrolidine Dithiocarbamate (PDTC) is a metal chelating compound with antioxidant properties. PDTC is a copper and zinc ionophore and exerts many different effects in biological systems. It is able to inhibit the activation of NFB, the replication of picornaviruses and proteasome-dependent proteolysis.
openaire   +1 more source

Pd (II)- pyrrolidine dithiocarbamate complexes: Synthesis, spectroscopic studies and molecular structure of [Pd(PyDT)(ppy)]

, 2021
S. Al-Jibori, Ahmed S. M. Al‐Janabi, Serwan W.M. Al-Sahan, C. Wagner   +3 more
semanticscholar   +1 more source

Effects of pyrrolidine dithiocarbamate on endothelial cells: protection against oxidative stress

Free Radical Biology and Medicine, 1999
The dithiocarbamates are well known for their antioxidant properties and effects on cellular transcriptional events. For example, pyrrolidine dithiocarbamate (PDTC) is widely used as an inhibitor of nuclear factor kappa B (NFkappaB) and this, or related compounds may have therapeutic potential in inhibiting atherosclerosis.
D, Moellering, J, McAndrew, H, Jo, V M, Darley-Usmar   +3 more
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Repeated exposure to pyrrolidine-dithiocarbamate induces peripheral nerve alterations in rats

Toxicology Letters, 2005
Pyrrolidine-dithiocarbamate (PDTC), a synthetic compound widely used in cell biological investigations, recently attracted considerable interest as a putative anticancer agent. However, different dithiocarbamates have previously shown to cause neurological symptoms and morphological alterations in peripheral nerves. The purpose of the present study was
Gabriella, Calviello, Guido Maria, Filippi, Amelia, Toesca, Paola, Palozza, Nicola, Maggiano, Fiorella Di, Nicuolo, Simona, Serini, Gian Battista, Azzena, Tommaso, Galeotti   +8 more
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PYRROLIDINE DITHIOCARBAMATE IMPROVES THE SEPTIC SHOCK SYNDROMES IN SPONTANEOUSLY HYPERTENSIVE RATS

Clinical and Experimental Pharmacology and Physiology, 1998
SUMMARY1. The aim of the present study was to evaluate the effect of pyrrolidine dithiocarbamate (PDTC), an inhibitor of nuclear factor‐kB (NF‐kB), on septic shock induced by Escherichia coli lipopolysaccharide (LPS) in spontaneously hypertensive rats (SHR).2.
H J, Hong, C C, Wu, M H, Yen
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Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation.

British journal of pharmacology, 2002
The nuclear factor-kappaB (NF-kappaB) is a transcription factor which plays a pivotal role in the induction of genes involved in physiological processes as well as in the response to injury and inflammation. Dithiocarbamates are antioxidants which are potent inhibitors of NF-kappaB.
CUZZOCREA, Salvatore, CHATTERJEE PK, MAZZON E, DUGO, LAURA, SERRAINO I, BRITTI D, MAZZULLO, Giuseppe, CAPUTI, Achille, THIEMERMANN C.   +8 more
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Transcriptional regulation of the heme oxygenase 1 gene by pyrrolidine dithiocarbamate

The FASEB Journal, 1998
ABSTRACT Heme oxygenase 1 (HO‐1), a stress response protein, is highly induced in response to various agents causing oxidative stress including ultraviolet irradiation, sodium arsenite, hyperoxia, and glutathione depletors.
C L, Hartsfield, J, Alam, A M, Choi
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