Inhibition of NF-κB by Pyrrolidine Dithiocarbamate Prevents the Inflammatory Response in a Ligature-Induced Peri-Implantitis Model: A Canine Study [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: The roles of toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) in peri-implantitis are unclear. Here, we used a canine model of peri-implantitis to explore the effects of inhibiting NF-κB with pyrrolidine dithiocarbamate ...
Chun-Yan He +3 more
doaj +2 more sources
Inhibition of nuclear factor-κB signal by pyrrolidine dithiocarbamate alleviates lipopolysaccharide-induced acute lung injury. [PDF]
Oncotarget, 2017 This study mainly studied the effect of inhibition of nuclear factor-κB (NF-κB) signal by pyrrolidine dithiocarbamate (PDTC) on lipopolysaccharide (LPS)-induced inflammatory response, oxidative stress, and mitochondrial dysfunction in a murine acute lung
Yang H +8 more
europepmc +2 more sources
Protective effect of pyrrolidine dithiocarbamate against methotrexate-induced testicular damage [PDF]
Human & Experimental Toxicology, 2021 The aim of the study was to investigate the protective effect of pyrrolidine dithiocarbamate (PDTC) against methotrexate (MTX)-induced testicular damage in rats.
O. Delen, Y. H. Uz
semanticscholar +4 more sources
Short-term pyrrolidine dithiocarbamate administration attenuates cachexia-induced alterations to muscle and liver in ApcMin/+ mice. [PDF]
Oncotarget, 2016 Cancer cachexia is a complex wasting condition characterized by chronic inflammation, disrupted energy metabolism, and severe muscle wasting. While evidence in pre-clinical cancer cachexia models have determined that different systemic inflammatory ...
Narsale AA +6 more
europepmc +2 more sources
Neurobiology of Disease, 2006 It has been well established that neuroinflammation is involved in Alzheimer disease (AD) pathogenesis. Accumulation and aggregation of beta-amyloid (Aβ) peptide in the brains of patients with AD result in activation of glial cells which, in turn ...
Guanliang Cheng +3 more
doaj +2 more sources
Molecular Medicine Reports, 2019 Isoniazid (INH) and rifampicin (RIF) continue to be first line anti‑tuberculosis (TB) drugs. However, the use of these drugs is associated with hepatotoxicity. Nuclear factor‑κB (NF‑κB) plays a crucial role in regulating immunity and inflammation. It has
Xue He, Yulin Song, Li Wang, Jianming Xu
openalex +3 more sources
Protective effects of the nuclear factor kappa B inhibitor pyrrolidine dithiocarbamate on experimental testicular torsion and detorsion injury. [PDF]
Korean J Physiol Pharmacol, 2014 Testicular torsion results with the damage of the testis and it is a surgical emergency. Pyrrolidine dithiocarbamate (PDTC) is a low-molecular-weight antioxidant and potent inhibitor of nuclear factor kappa B (NF-κB) activation.
Kabay S +8 more
europepmc +2 more sources
Pyrrolidine Dithiocarbamate Alleviated Anxiety in Diabetic Mice [PDF]
Indian Journal of Pharmaceutical Sciences, 2017 Diabetes is often associated with psychological complications such as anxiety. The aim of this study was to evaluate the effects of pyrrolidine dithiocarbamate on anxiety of streptozotocin-induced diabetic mouse using the open field and the elevated plus
C. Guangpin +4 more
semanticscholar +2 more sources
Pyrrolidine dithiocarbamate ameliorates rotenone-induced Parkinson’s disease in rats
Bulletin of Faculty of Pharmacy Cairo University, 2017 Pyrrolidine dithiocarbamate (PDTC), a low-molecular-weight thiol antioxidant, possesses neuroprotection; however, its possible modulatory effect in Parkinson’s disease (PD) has not been tested.
Noha F. Abdelkader +4 more
doaj +2 more sources
Pyrrolidine dithiocarbamate accelerates early recovery of intestinal microvascular oxygenation in a reversible model of hemorrhagic shock in rats [PDF]
Journal of Translational MedicineBackground Improving intestinal tissue integrity appears to be crucial for maintaining global homeostasis in patients suffering from hemorrhagic shock. Since depletion of regional oxygen reserve might lead to cell death and tissue injury, the maintenance
Stefan Hof +11 more
doaj +2 more sources