Neurobiology of Disease, 2012 Evidence suggests an association between brain ischemia and Alzheimer's disease (AD) development. Amyloid plaques consisted of β-amyloid peptide (Aβ) in the brain are a pathological hallmark of AD. Little is known about how brain ischemia induces AD-like
Jiejie Li +3 more
doaj +2 more sources
Iraqi Journal of Pharmaceutical Sciences, 2019 5-Fluorouracil is one of the commonly used chemotherapy drugs in anticancer therapy; unfortunately treatment with 5-FU by solely has many drawbacks low lipophilicity, low permeability, low molecular weight, and its relatively poor plasma protein ...
Ikram K. Shihab, Mohammed H. Mohammed
doaj +3 more sources
Pyrrolidine dithiocarbamate inhibits herpes simplex virus 1 and 2 replication, and its activity may be mediated through dysregulation of the ubiquitin-proteasome system. [PDF]
J Virol, 2013 Pyrrolidine dithiocarbamate (PDTC) is widely used as an antioxidant or an NF-κB inhibitor. It has been reported to inhibit the replication of human rhinoviruses, poliovirus, coxsackievirus, and influenza virus.
Qiu M +5 more
europepmc +2 more sources
Mediators of InflammationSpinal cord injury (SCI) triggers severe neuroinflammation, impeding recovery. While microglial M1 polarization and pyroptosis are key drivers, their upstream regulators are incompletely understood.
Xin Lin +7 more
doaj +2 more sources
Early administration of pyrrolidine dithiocarbamate extends the therapeutic time window of tissue plasminogen activator in a male rat model of embolic stroke. [PDF]
J Neurosci Res, 2018 Wang Z +5 more
europepmc +3 more sources
An experimental study on effects of pyrrolidine dithiocarbamate on ischemia-reperfusion injury in testis. [PDF]
Can Urol Assoc J, 2016 Kemahli E +6 more
europepmc +2 more sources
Synergistic cytotoxic effect of sulindac and pyrrolidine dithiocarbamate against ovarian cancer cells. [PDF]
Oncol Rep, 2012 Jakubowska-Mućka A +4 more
europepmc +3 more sources
Zinc is required in pyrrolidine dithiocarbamate inhibition of NF‐κB activation [PDF]
FEBS Letters, 1999 Pyrrolidine dithiocarbamate (PDTC) is a potent inhibitor of nuclear factor kappa B (NF‐κB) activation. PDTC inhibited basal NF‐κB activity of endothelial cells. PDTC, however, failed to inhibit basal NF‐κB activity after withdrawal of serum in the media, and the inhibitory effect of PDTC could be restored by addition of zinc.
Chul Hoon Kim +3 more
openalex +5 more sources
Regulatory effect of cytokine-induced neutrophil chemoattractant, epithelial neutrophil-activating peptide 78 and pyrrolidine dithiocarbamate on pulmonary neutrophil aggregation mediated by nuclear factor-κB in lipopolysaccharide-induced acute respiratory distress syndrome mice. [PDF]
Exp Ther Med, 2016 Wang H +6 more
europepmc +3 more sources
Pathology - Research and Practice, 2013 We aimed to demonstrate the potential protective effects of pyrrolidine dithiocarbamate (PDTC) on monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). Adult male rats were randomly assigned to 4 groups: control group, MCT-treated rats only, MCT-injected rats treated with PDTC, and PDTC-treated rats only.
Taner Yavuz +7 more
openalex +7 more sources