Results 61 to 70 of about 39,221 (244)

Possible Therapeutic Options for Complex Regional Pain Syndrome

Biomedicines, 2021
Complex regional pain syndrome (CRPS) describes an array of painful conditions that are characterized by continuing regional pain. CRPS comprises severe and inappropriate pain in cases of complete recovery after trauma.
Myeounghoon Cha, Kyung Hee Lee, Minjee Kwon, Bae Hwan Lee   +3 more
doaj   +1 more source

A novel technique for selective NF-kappa B inhibition in Kupffer cells: contrary effects in fulminant hepatitis and ischaemia-reperfusion. [PDF]

, 2009
Background and aims: The transcription factor nuclear factor kappa B (NF-kB) has risen as a promising target for anti-inflammatory therapeutics. In the liver, however, NFkB inhibition mediates both damaging and protective effects.
A. Hartkorn, A. L. Gerbes, A. M. Vollmar, C. Coester, F. Hoffmann, G. Sass, G. Tiegs, G. Winter, J. Wagner, J. Zillies, S. Fuchs, S. Zahler   +11 more
core   +1 more source

Pyrrolidine Dithiocarbamate Reduces Vascular Prostanoid-Induced Responses in Aged Type 2 Diabetic Rat Model

Journal of Pharmacological Sciences, 2009
.: It has been shown that enhancement of vasoconstrictor prostanoids plays an important role in the development of cardiovascular diseases. The aim of the present study was to examine the effects of pyrrolidine dithiocarbamate (PDTC), a low-molecular ...
Takayuki Matsumoto, Keiko Ishida, Tsuneo Kobayashi, Katsuo Kamata   +3 more
doaj   +1 more source

Blockade of T-cell activation by dithiocarbamates involves novel mechanisms of inhibition of nuclear factor of activated T cells. [PDF]

, 1997
Dithiocarbamates (DTCs) have recently been reported as powerful inhibitors of NF-kappaB activation in a number of cell types. Given the role of this transcription factor in the regulation of gene expression in the inflammatory response, NF-kappaB ...
Algarté M., Aramburu J., Baeuerle P. A., Baichwal V. R., Beals C. R., Beg A. A., Bessho R., Boise L. H., Burns G. F., Chuvpilo S. D., Cockerill P. N., Cockerill P. N., Cotter T. G., Crabtree G. R., Crabtree G. R., Durand D. B., Goldfeld A. E., Gómez del Arco P., Hibi M., Ho S. N., Ho S. N., Hodge M. R., Hoey T., Izquierdo M., Jain J., Jain J., Lee H. J., Liu J., Loh C., Los M., Luo C., Luo C., Luo C., Masuda E. S., Masuda E. S., Mauri N., McCaffrey P. G., Meyer M., Minden A., Muoz C., Muoz C., Nobel C. S. I., Northrop J. P., Prieschl E. E., Radler-Pohl A., Rao A., Reisinger E. C., Rooney J. W., Ruff V. A., Schenk H., Schreck R., Schreck R., Schreiber E., Schreiber S. L., Schulze-Osthoff K., Schulze-Osthoff K., Sen C. K., Shaw J. P., Shaw K. T., Shibasaki F., Spits H., Staal F. J. T., Szabo S. J., Sánchez-Mateos P., Timmerman L. A., Traenckner E.B., Truneh A., Van Antwerp D. J., Wang C., Weiss A., Wu M., Xanthoudakis S., Yano O.   +72 more
core   +3 more sources

Possible Underlying Influence of p38MAPK and NF-κB in the Diminished Anti-anxiety Effect of Diazepam in Stressed Mice

Journal of Pharmacological Sciences, 2011
.: The present study was designed to explore the possible nitriergic influence and role of p38MAPK and NF-κB in the diminished anti-anxiety effect of diazepam in stressed mice, using the elevated plus maze and light/dark box to assess anxiety ...
Vipin Sharma, Ritu Gilhotra, Dinesh Dhingra, Neeraj Gilhotra   +3 more
doaj   +1 more source

FGF-2 inhibits TNF-α mediated apoptosis through upregulation of Bcl2-A1 and Bcl-xL in ATDC5 cells [PDF]

BMB Reports, 2012
FGF-2 is involved in cell survival, proliferation, apoptosis, andangiogenesis in a wide variety of cells. FRGRs, PI3K and MAPkinases are well known mediators of FGF signaling.
Hey-Ryun Kim, Youn-Moo Heo, Kyoung-Il Jeong, Yong-Min Kim, Hae Lan Jang, Kwang-Yeol Lee, Chang-Yeol Yeo, Sung Hoon Kim, Hak-Kyo Lee, Seung-Ryul Kim, Eung-Gook Kim, Joong-Kook Choi   +11 more
doaj   +1 more source

Crystal structure of [μ2-1,1′-bis(diphenylphosphanyl)ferrocene-κ2P:P′]bis[(pyrrolidine-1-carbodithioato-κS)gold(I)] [PDF]

, 2015
The asymmetric unit of the title compound, {(C34H28FeP2)[Au(C5H8NS2)]2}, comprises half a molecule, with the full molecule being generated by the application of a centre of inversion.
Tan, Yee Seng *, Tiekink, Edward R. T. *
core   +2 more sources

MAPK phosphatase-1 represents a novel antiinflammatory target of glucocorticoids in the human endothelium [PDF]

, 2007
Glucocorticoids are well-established anti- inflammatory drugs thought to mainly act by inhibition of proinflammatory transcription factors like NF-κB.
Bubik, Martin F., Eilken, Hanna M., Fürst, Robert, Kiemer, Alexandra K., Schroeder, Timm, Vollmar, Angelika M., Zahler, Stefan   +6 more
core   +1 more source

Desiccating stress-induced disruption of ocular surface immune tolerance drives dry eye disease [PDF]

, 2016
Dry eye is an allegedly autoimmune disorder for which the initiatingmechanisms and the targeted antigens in the ocular surface are not known,yet there is extensive evidence that a localized T helper type 1 (Th1)/Th17effector T cell response is ...
Galletti, Jeremías Gastón, Giordano, Mirta Nilda, Guzman, Mauricio, Keitelman, Irene Angélica, Sabbione, Florencia, Trevani, Analía Silvina   +5 more
core   +1 more source

Ammonium pyrrolidine dithiocarbamate adsorption on copper surface in neutral chloride media

, 2016
W. Qafsaoui, M. Kendig, S. Joiret, Hubert Perrot, H. Takenouti   +4 more
openalex   +3 more sources