Results 151 to 160 of about 29,810 (265)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, Volume 15, Issue 4, April 2026.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

2,3‐Dichloro‐5,6‐Dicyano‐1,4‐Benzoquinone (DDQ)‐Mediated CC Bond Formation: Redox Strategies from Stoichiometric to Catalytic Systems

ChemistryOpen, Volume 15, Issue 4, April 2026.
2,3‐Dichloro‐5,6‐dicyano‐1,4‐benzoquinone serves as a versatile oxidant and redox catalyst for CC bond formation through hydride abstraction or single‐electron transfer. Stoichiometric and catalytic systems enable benzylic, allylic, and aromatic CH activation under mild, metal‐free conditions, providing sustainable routes to complex and bioactive ...
Dohoon Cha, Sun‐Joon Min
wiley   +1 more source

Structural Modeling and Dynamics of the Full‐Length Homer1 Multimer

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 4, Page 947-960, April 2026.
ABSTRACT Homer proteins are modular scaffold molecules that constitute an integral part of the protein network within the postsynaptic density. Full‐length Homer1 forms a large homotetramer via a long coiled coil region, and can interact with proline‐rich target sequences with its globular EVH1 domain.
Zsófia E. Kálmán, András Czajlik, Brigitta Maruzs, Fanni Farkas, István Pap, Csilla Homonnay, Tomas Klumpler, Gyula Batta, Zoltán Gáspári, Bálint Péterfia   +9 more
wiley   +1 more source

Photoredox-enabled late-stage functionalization of pyrrolidines in batch and flow: rapid access to benzothiazole hybrids as a new class of cholinesterase inhibitors. [PDF]

RSC Adv
Filipović A, Vučkovski M, Mićović D, Bondžić AM, Bondžić BP.   +4 more
europepmc   +1 more source

Bi/Bi2O3 Nanoparticles In Situ Embedded in Carbon as Anode Materials for Fast and Long‐Lasting Sodium–Ion Storage

Rare Metals, Volume 45, Issue 4, April 2026.
ABSTRACT Bismuth anode materials are considered promising anode candidates for sodium–ion batteries (SIBs) due to their high theoretical capacity and appropriate working potential. Nevertheless, the significant volume expansion that occurs during the cycling process restricts its broader application in sodium–ion storage. Herein, Bi/Bi2O3 nanoparticles
Jiaju Lu, Weiya Tian, Xiaoling Wang, Junxian Hu   +3 more
wiley   +1 more source

Light-Driven Stereoselective Aryl Bisenone Cycloaddition: A Metal-Free Strategy for the Construction of Functionalized Pyrrolidines and Tetrahydrofurans

SynOpen
Francesca Franco, Tommaso Benettin, Fabrizio Medici, Sergio Rossi, Simonetta Resta, Alessandra Puglisi, Maurizio Benaglia   +6 more
doaj   +1 more source

Desymmetrization of <i>meso</i>-Pyrrolidines via Oxoammonium-Catalyzed Enantioselective Hydride Transfer. [PDF]

J Am Chem Soc
Rein J, Górski B, Keskin AM, Le MH, Lin S.   +4 more
europepmc   +1 more source

Pre‐Formation of LiF‐Rich Interfaces on Prelithiated Si/C Anodes for High‐Energy Lithium‐Ion Batteries

Rare Metals, Volume 45, Issue 4, April 2026.
ABSTRACT Prelithiation is effective for compensating active lithium‐ion (Li+) loss in silicon (Si)‐based battery electrode materials. However, owing to the dynamic growth of the solid electrolyte interface (SEI), capacity fading remains the biggest challenge for the industrialization of Si electrodes.
Wen‐Jie He, Wei Xu, Xiu‐Ying Jin, Bo‐Nan Wang, Wen‐Jie Liu, Yue Xiao, Gang Qin, Takayuki Ichikawa, Gai Wu, Teng‐Fei Zhang   +9 more
wiley   +1 more source

Convergence and parallelism in the evolution of plant metabolism

Journal of Integrative Plant Biology, Volume 68, Issue 4, Page 1013-1031, April 2026.
Similar traits in different organisms may originate from shared ancestry or evolve independently. The terminology used to define phenotypic similarity is often confusing. This review attempts to clarify the definitions and present examples from plant domestication and specialized metabolism to explain how complex traits evolve repeatedly in plants ...
Federico Scossa, Mustafa Bulut, Thomas Naake, John C. D'Auria, Alisdair R. Fernie   +4 more
wiley   +1 more source

A Polarity-Mismatched Photocatalytic Cross-Coupling Enables Diversity-Oriented Synthesis of aza-Heterocycles. [PDF]

Org Lett
Urbańczyk J, McKay AP, Cordes DB, Lebl T, Aukland MH, Watson AJB.   +5 more
europepmc   +1 more source