Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles
European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu +2 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.The successful extension of the nickel‐catalyzed asymmetric coupling of polarized 1,3‐dienes with aldehydes to an intramolecular setting opens an efficient new entry into hydroxylated N‐heterocyclic compounds, most notably valuable tetrahydroisoquinolines.
Thilo Bender +3 more
wiley +2 more sources
Organocatalytic Asymmetric Formal Aza-[3 + 2] Cycloaddition via Domino Michael/Acetalization: Stereoselective Access to 3,4-<i>cis</i>-Disubstituted Pyrrolidines and Pot-Economical Total Syntheses of (-)-Kainic Acid and (-)-Domoic Acid. [PDF]
JACS AuHatano Y +3 more
europepmc +1 more source
Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.Dual‐functional polystyrene‐based polymers bearing 2,2′‐(pyridine‐2,6‐diyl)diphenol (PDP) moieties form photoexcitable alkyl borate complexes: (i) As recyclable radical sources, they enable Giese‐type additions with facile purification by reprecipitation and demonstrate proof‐of‐concept for polymer recovery (50% PDP regeneration).
Nami Jimba +9 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.Modifying the conformational ensemble of “molten‐globule” protein by the site‐specific incorporation of stereoisomeric 4‐fluoroproline residues modulated its binding affinity and aggregation behavior. 19F NMR spectroscopy enabled the detection of key interactions responsible for structural and dynamic changes. ABSTRACT Recently, the application of deep
Abir Ben Bouzayene +5 more
wiley +2 more sources
Chiral 3-acyl-2-pyrrolines as strategic hubs toward polycyclic pyrrolidines <i>via</i> enantioselective silver-catalyzed Michael addition-cyclization. [PDF]
Chem SciSakai S, Maeda K, Shimizu Y, Sawamura M.
europepmc +1 more source
Counterion Effects in Decatungstate Photocatalysis
European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.Decatungstate photocatalysis is often discussed from an anion‐centered perspective, treating the counterion as a passive charge‐balancing species. This review highlights that counterion identity can instead profoundly influence catalyst solubility, ion pairing, aggregation, stability, substrate accessibility, and catalytic performance.
Florence Babawale +2 more
wiley +1 more source
Deconstruction of Aspartic Protease Inhibitors Enables Fragment-Based Discovery of Plasmepsin V Inhibitors. [PDF]
ChemMedChemSkvorcova M +4 more
europepmc +1 more source
Enantioselective hydrogen atom relay via non-covalent catalyst assembly. [PDF]
NatureYalamanchili N +3 more
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Radical Cyclization Approaches to Pyrrolidines
, 2002 Five-membered rings are readily prepared by 5-exo-trig radical cyclization. This thesis is concerned with novel methodology for pyrrolidine synthesis. We have synthesised selenium containing radical precursors from aziridines and α-phenylseleno ketones ...
Beşev, Magnus
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