Results 131 to 140 of about 26,509 (243)
ChemistryEuropeAlkylidenecyclopropanes (ACPs) can work as versatile 3 C partners in a range of [3+n] cycloadditions with unsaturated carbon partners. We now demonstrate that they can also be harnessed for inter‐ and intramolecular palladium‐catalyzed [3+2] formal ...
Ricardo Rodiño +3 more
doaj +1 more source
Peptide binding at the gasdermin D exosite reveals the structural basis for targeting the site
Acta Crystallographica Section D, Volume 82, Issue 6, Page 615-625, June 2026.We describe the first structure of gasdermin D with a putative caspase inhibitor peptide analog at 1.6 Å resolution. This work suggests potential druggability of gasdermin D at the exosite by leveraging structure‐based computational design with biochemical characterization.Gasdermin D (GSDMD) has been identified as a critical component of the ...
Renjing Wang +15 more
wiley +1 more source
Journal of Food Process Engineering, Volume 49, Issue 6, June 2026.Protein hydrolysate was successfully developed from defatted Zophobas morio flour. The pepsin hydrolysate exhibited superior properties compared to Brauzyn. The hydrolysis process with pepsin achieved a notable hydrolysis degree and yield. Pepsin hydrolysate from Z. morio showed high protein content and solubility.
Cristiani Viegas Brandão Grisi +8 more
wiley +1 more source
ChemBioChem, Volume 27, Issue 10, 27 May 2026.We developed fluorescent molecular rotors (FMRs) that respond sensitively to intracellular viscosity. Based on the dye scaffold of GFP, we systematically investigated molecular rigidity and surface area, and discovered FMRs with remarkably high viscosity sensitivity.
Takashi Kanamori +7 more
wiley +1 more source
ChemSusChem, Volume 19, Issue 10, 27 May 2026.Indoles are promising N‐heterocyclic liquid organic hydrogen carriers. Here, we investigate the reaction pathways of (methyl)indole (de)hydrogenation over Pd catalysts using reaction experiments and computational modeling: we show that distinct intermediates are formed in hydrogenation versus dehydrogenation steps, and stereocenter evolution is ...
Matthew D. Edgar +6 more
wiley +1 more source
ChemSusChem, Volume 19, Issue 10, 27 May 2026.Urea electrosynthesis from CO2 and nitrate offers a sustainable alternative to fossil‐fuel‐based production. This review examines recent progress in reaction mechanisms, electrocatalysts, and detection methods for urea and intermediates. By identifying critical research challenges, we highlight potential strategies to optimize efficiency and overcome ...
Alessandro Bani +5 more
wiley +1 more source
Recent Approaches for the Synthesis of Pyridine and Quinoline Cores Present in Natural Products
Advanced Synthesis &Catalysis, Volume 368, Issue 10, 19 May 2026.An anthology of the most recent methods used to synthesize pyridines and quinolines found in natural products over the last decade. Pyridines, quinolines, and their derivatives represent a class of significant heterocyclic compounds that are prevalent in a multitude of natural products, including alkaloids found in plants, fungi, insects, marine ...
Carl Bowman +2 more
wiley +1 more source
In‐situ‐Konstruktion von Imidazopyridinium‐Fluoreszenzlabels für Biokonjugationen
Angewandte Chemie, Volume 138, Issue 21, 18 May 2026.Durch Chromophor‐Engineering von Isochinolinaldehyden entstehen TICT‐basierte fluorogene Farbstoffe für die In Situ Markierung unterschiedlicher (Bio‐)Moleküle mit großen Stokes‐Verschiebungen, die mit der Zellbildgebung kompatibel sind. ZUSAMMENFASSUNG Einfache, effiziente Transformationen fluorogenen Charakters, die unter biokompatiblen Bedingungen ...
Dongchen Du +7 more
wiley +1 more source
In Situ Construction of Imidazopyridinium Fluorescent Labels for Bioconjugation
Angewandte Chemie International Edition, Volume 65, Issue 21, 18 May 2026.Chromophore engineering of isoquinoline aldehydes generates TICT‐based fluorogenic dyes for in situ labeling of diverse (bio)molecules with large Stokes shifts compatible with cell imaging. ABSTRACT Simple, efficient transformations of fluorogenic nature that proceed under biocompatible conditions without the formation of byproducts are of high ...
Dongchen Du +7 more
wiley +1 more source