Results 111 to 120 of about 23,799 (225)

Desymmetrization of <i>meso</i>-Pyrrolidines via Oxoammonium-Catalyzed Enantioselective Hydride Transfer. [PDF]

J Am Chem Soc
Rein J, Górski B, Keskin AM, Le MH, Lin S.   +4 more
europepmc   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

A Polarity-Mismatched Photocatalytic Cross-Coupling Enables Diversity-Oriented Synthesis of aza-Heterocycles. [PDF]

Org Lett
Urbańczyk J, McKay AP, Cordes DB, Lebl T, Aukland MH, Watson AJB.   +5 more
europepmc   +1 more source

Enantioselective Alkyne-Mediated Aldehyde Allylation of Alcohol Proelectrophiles Using RuHCl(CO)(PPh₃)₃ as Precatalyst. [PDF]

Org Lett
Evarts MM, Nguyen TN, Krische MJ.
europepmc   +1 more source

Chemoselective Synthesis of δ-Amino Alcohols from Chiral 1,4-Diols Catalyzed by an NHC-Ir(III) Complex. [PDF]

Org Lett
Silvi E, Bermejo-López A, Jabbari S, Pettersson M, Johansson MJ, Martín-Matute B.   +5 more
europepmc   +1 more source

The impact of tobacco cessation on buccal mucosa cancer risk: A multi‐centre case–control study in India

International Journal of Cancer, Volume 159, Issue 2, Page 368-377, 15 July 2026.
What's new? While the association between tobacco consumption and oral cancer is well established, the effect of cessation, particularly of chewing tobacco, the most common tobacco product in South Asia, is understudied. This case–control study in an Indian population demonstrates that a longer duration of tobacco smoking and chewing cessation is ...
Gayathri B. Pullat, Bastian Bohrmann, Grace Sarah George, Shubham Dikshit, Arjun Singh, Pankaj Chaturvedi, Rajesh Dikshit, Sarah Lewington, Sharayu Mhatre   +8 more
wiley   +1 more source

Regio- and Stereoselective Deprotonation and Functionalization of Strained 1-Aza[n.1.0]bicycles. [PDF]

J Am Chem Soc
Xie T, Plowright T, Somper JD, Fairchild M, Soler J, Tyler JL, Duarte F, Aggarwal VK.   +7 more
europepmc   +1 more source

Molecular Hybridization of Clinically Relevant P2X7 Antagonists

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
We employed a molecular hybridization strategy, combining clinically validated antagonists AZD‐9056 and JNJ‐54175446, to design and synthesize a library of novel adamantane‐containing P2X7R antagonists. Pharmacological and in silico analyses indicate that these adamantyl hybrids adopt a distinct, shallow binding mode within the P2X7R allosteric pocket,
Nicholas B. Lynch, Charleigh T. A. Agius, André D. J. McKenzie, Jessica O’Driscoll, Angus Tolmie, Taylor R. Garrett, Eryn Werry, Michael Kassiou   +7 more
wiley   +1 more source

Regio- and Stereocontrolled-Synthesis of a Heterocycle Fragment Collection Using Palladium Catalyzed C-H Arylation. [PDF]

Chemistry
Piticari AS, Antermite D, Linkhorn HJ, Larionova NA, Webster MP, Bull JA.   +5 more
europepmc   +1 more source