Results 111 to 120 of about 26,509 (243)
Unusual backfolded binding poses of BAZ2A bromodomain binders
Acta Crystallographica Section D, EarlyView.We identified BAZ2A‐binding compounds assuming a peculiar, almost enclosed, conformation. These molecules pose a basis for the development of potent BAZ2A macrocyclic inhibitors, as performed for other bromodomains.BAZ2A is a large multidomain protein overexpressed in aggressive prostate cancer, where it potentiates migration and invasion of other ...
Andrea Dalle Vedove +5 more
wiley +1 more source
Deciphering Role of Endophytes in Plant Defences and Biotic Stress Resilience Across Families
Plant, Cell &Environment, EarlyView.ABSTRACT Plant families generate distinct repertoires of specialised metabolites that govern their biotic interactions. Endophytes strengthen host plant defence mechanisms and tolerance to biotic challenges by upregulating metabolite biosynthesis, modifying precursor compounds into more potent forms, or by directly synthesising analogous defence ...
S. Aneeqa Noor +4 more
wiley +1 more source
International Journal of Cancer, Volume 159, Issue 2, Page 368-377, 15 July 2026.What's new? While the association between tobacco consumption and oral cancer is well established, the effect of cessation, particularly of chewing tobacco, the most common tobacco product in South Asia, is understudied. This case–control study in an Indian population demonstrates that a longer duration of tobacco smoking and chewing cessation is ...
Gayathri B. Pullat +8 more
wiley +1 more source
Synthèse de pyrrolidines chirales non-racémiques
, 2018 Le présent projet a été réalisé dans le cadre d'une collaboration UniversitéIndustrie entre le laboratoire du professeur Robert Chênevert, à l'Université Laval et la compagnie OmégaChem, de Lévis.
Giroux, Martin
core
Asymmetric Synthesis of 3-Hydroxy-pyrrolidines via Tin−Lithium Exchange and Cyclization
, 2016 We report a method for the synthesis of chiral pyrrolidines using tin−lithium exchange and cyclization reactions. The precursors are formed readily from simple starting materials and undergo tin−lithium exchange by treatment with n-butyllithium ...
Iain Coldham (1370430) +3 more
core +1 more source
Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.Asymmetric Michael addition of cyanide to α,β‐unsaturated aldehydes catalyzed by diarylmethyl‐substituted diphenylprolinol silyl ethers:Thermodynamically controlled product formation under kinetic enantioselective catalysis. Diphenylprolinol silyl ether catalyzed asymmetric Michael/1,2‐addition reaction of cyanide to α,β‐unsaturated aldehydes at high ...
Konstantinos Daskalakis +4 more
wiley +1 more source
Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.The cine‐substitution of 2‐aryl‐1‐chlorovinyl p‐tolyl sulfoxides with lithium amides yields β‐enamino sulfoxides with high efficiency. β‐Enamino sulfoxides are desulfinylated via the sulfoxide/magnesium exchange reaction with isopropylmagnesium chloride to yield enamines.
Tsutomu Kimura +4 more
wiley +1 more source
Optimisation of a Novel Class of DNA Gyrase Inhibitors to Improve Antibacterial Activity
ChemMedChem, Volume 21, Issue 11, 15 June 2026.This article describes efforts to increase the antibacterial activity of a recently reported class of novel DNA gyrase inhibitors known as the isoquinoline sulphonamides by improving their uptake in bacterial cells. As antibiotic resistance continues to rise, the need for new antibacterials is clear.
Meg I. Ferguson +9 more
wiley +1 more source
ChemSusChem, Volume 19, Issue 11, 15 June 2026.This review analyzes deep eutectic solvents (DESs) as efficient media for both organic and inorganic electrosynthesis. The improvements in terms of synthetic opportunities and sustainability are discussed, by exploring the multiple roles of DESs as solvents, electrolytes, and promoters, enabling effective and selective electrosynthesis under mild and ...
Cristiana Margarita +6 more
wiley +1 more source