Results 121 to 130 of about 29,047 (251)

Telescoped Synthesis of Stereodefined Pyrrolidines

, 2016
Telescoped and one-pot olefination/asymmetric functionalization approaches to disubstituted pyrrolidines (dr up to 99:1, up to 99% ee) have been developed using commercially available tetramisole (0.1 to 5 mol %).
Alexandra M. Z. Slawin (809268), David B. Cordes (809266), Dorine Belmessieri (1939315), Andrew D. Smith (494170)   +3 more
core   +1 more source

Convenient and Sustainable Reduction of β‐Nitrostyrenes

ChemistrySelect, Volume 11, Issue 41, 3 November 2026.
A robust procedure for the synthesis of phenethylamines from the corresponding nitrostyrenes has been developed on multi‐gram scale. Using cheap reagents and green solvents the product is isolated in high yield and purity using a minimum of organic solvents without the need for chromatographic purification.
Christian B. M. Poulie, Adrian G. Rossebø, Jonas K. Hundborg, Emil R. H. Andersen, Birka M. von Holck, Laura M. Lange, Astrid V. Johannsen, Silvia P. Pastor, Jesper L. Kristensen   +8 more
wiley   +1 more source

1,4‐Brook Rearrangement of β‐Silyl Allylic Alcohols: Trisubstituted Alkenes by Copper‐Mediated Stereoretentive ipso‐Substitution Reactions

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
To fully leverage the power of the ruthenium‐catalyzed trans‐hydrosilylation of propargyl alcohols, it was necessary to develop a practical and robust method for the activation of those products that carry the silyl group distal to the hydroxy substituent.
Paul Haf‐Moths, Jack L. Sutro, Alois Fürstner   +2 more
wiley   +2 more sources

Chemoproteomic discovery of a brain‐penetrant, covalent NLRP3 inhibitor that binds a novel allosteric pocket

British Journal of Pharmacology, Volume 183, Issue 22, Page 6718-6734, November 2026.
NLRP3 is a promising inflammatory target, but existing inhibitors lack diversity and brain penetrance, and none are approved. Using chemoproteomics, we discovered a novel series that binds to Cys463 in a previously uncharacterized pocket. Compounds showed nanomolar potency, brain exposure, and in vivo suppression of IL‐1β, supporting neuroinflammatory ...
Donald C. Rogness, Evelyn P. Sievert, Vincent F. Vartabedian, Steffen M. Bernard, Erick Aitchison, William Tao, Mikaela Lindvall, Jing Qian, Christie L. Eissler, Brian E. Nordin, Benjamin D. Horning, Cian Kingston, Kelsey N. Lamb, Joshua C. Bell, Bingwen Lu, Jonathan Pollock, Jun Shi, Roli Khattri, David S. Weinstein, Matthew P. Patricelli, Brian N. Cook, Gabriel M. Simon   +21 more
wiley   +1 more source

Sustainable Access to N‐Heterocycles: One‐Pot Cascade Synthesis of Pyrroles From Bio‐Derived Furans

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
Highly dispersed platinum (Pt) clusters on Brønsted acid‐rich HY zeolite enable a one‐pot cascade conversion of bio‐derived furans and nitroarenes into pyrroles. Highly dispersed Pt sites ensure selective nitro hydrogenation, while Pt nanoparticles promote undesired over‐hydrogenation.
Haifeng Qi, Germán López Robledo, Jianglin Duan, Yujing Ren, Kathrin Junge, Matthias Beller   +5 more
wiley   +2 more sources

A novel access to dispirocyclohexanoneindano pyrrolidines

, 2010
127-130Synthesis of a series of novel dispirocyclohexanoneindano pyrrolidines has been described. The cycloaddition reaction of azomethine ylide generated from ninhydrin and sarcosine with bisarylidenecyclohexanones was found to be highly region ...
Raghunathan, Raghavachary, Poornachandran, Mahalingam   +1 more
core  

Rapid Translation of the Early Coding Region Promotes Premature Transcription Termination, Reducing Protein Expression in Escherichia coli

Molecular Microbiology, Volume 126, Issue 5, Page 519-531, November 2026.
A run of consecutive fast‐translated codons (right) within the first 30 codons of lacZ (top) causes loss of the downstream transcript at positions coinciding with previously mapped intragenic Rho‐dependent termination sites (middle), and a corresponding loss of β‐galactosidase activity (bottom).
Steen Pedersen, Alberte Honoré Jepsen, Bertil Gummesson, Namiko Mitarai, Kim Sneppen, Sine Lo Svenningsen   +5 more
wiley   +1 more source

Synthesis of Nitrogen‐Containing Heterocyclic Scaffolds and Applications in Scaffold Hopping: Development of an Aripiprazole Analog

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
A series of 12 novel fused [6,6] saturated and unsaturated nitrogen bicycles is synthesized in three to five steps and expands the CRAFT library's fragment space. A 2,6‐naphthyridin‐3‐ol core replaces the dihydroquinolinone scaffold of aripiprazole, a scaffold‐hopping strategy.
Temitayo Omowumi Alegbejo Price, Pieterjan Winant, Paulo Eliandro da Silva Júnior, Shaiani Maria Gil de Melo, Pedro Henrique Gobira, Julia Possamai Gimenes, Pedro Tenório Teixeira Fernandes Leite, Vinícius Gonçalves Maltarollo, Gustavo Henrique Goulart Trossini, A. Ganesan, Sâmia Regiane Lourenço Joca, Wim Dehaen, Flavio da Silva Emery   +12 more
wiley   +1 more source

Palladium‐Catalyzed [3+2] Cycloadditions of Alkylidenecyclopropanes to Imines: A Direct Approach to Pyrrolidine Scaffolds

ChemistryEurope
Alkylidenecyclopropanes (ACPs) can work as versatile 3 C partners in a range of [3+n] cycloadditions with unsaturated carbon partners. We now demonstrate that they can also be harnessed for inter‐ and intramolecular palladium‐catalyzed [3+2] formal ...
Ricardo Rodiño, Felipe Verdugo, José L. Mascareñas, Fernando López   +3 more
doaj   +1 more source

Photochromic Donor–Acceptor Naphthalenediimides Enabling Near‐Infrared Photothermal Conversion for Seawater Desalination

Chemistry – A European Journal, Volume 32, Issue 40, 27 October 2026.
Photoinduced radical formation in donor–acceptor NDI molecules generates strong near‐infrared absorption, enabling efficient photothermal conversion and solar‐driven seawater desalination. ABSTRACT Photochromic donor–acceptor molecules that produce near‐infrared (NIR) absorption upon light activation offer promising platforms for organic photothermal ...
Sotaro Kusumoto, Soushi Kurihara, Masaya Shimabukuro, Naoki Ogiwara, Nobutsugu Hamamoto, Jack Harrowfield, Yang Kim, Yoshihiro Koide   +7 more
wiley   +1 more source