Results 121 to 130 of about 26,509 (243)

Asymmetric Synthesis of α‑Trifluoromethyl Pyrrolidines through Organocatalyzed 1,3-Dipolar Cycloaddition Reaction

, 2017
The optically active α-trifluoromethyl pyrrolidines have been achieved through organocatalyzed 1,3-dipolar cycloaddition reaction first. With diphenylprolinol trimethylsilyl ether as catalyst and in the presence of 3,5-dinitrobenzoic acid, the reaction ...
Kairong Wang (1555183), Yuanyuan Zhu (418127), Rui Wang (52434), Cui Wang (141700), Boyu Li (3872902), Zhenghao Dong (1737685), Wenjin Yan (1457071)   +6 more
core   +1 more source

Metalloamination/Cyclization of Zinc(II) Amides Derived from N,N-Dimethylhydrazinoalkenes—Applications for the Direct C-SP² Functionalization of Aryl and Vinyl Electrophiles

Inorganics
Treatment of N,N-dimethylhydrazinoalkenes with diethylzinc followed by exposure of the resulting ethylzinc amides to high vacuum drives a Schlenck redistribution metalloamination/cyclization to generate the corresponding bis(organozinc) intermediates in ...
Jérome Lépeule, Christian Frabitore, Tom Livinghouse   +2 more
doaj   +1 more source

A novel access to dispirocyclohexanoneindano pyrrolidines

, 2010
127-130Synthesis of a series of novel dispirocyclohexanoneindano pyrrolidines has been described. The cycloaddition reaction of azomethine ylide generated from ninhydrin and sarcosine with bisarylidenecyclohexanones was found to be highly region ...
Raghunathan, Raghavachary, Poornachandran, Mahalingam   +1 more
core  

N-Phosphorylated Pyrrolidines: An Overview of Synthetic Approaches

, 2020
© 2020 Georg Thieme Verlag. All rights reserved. Organophosphorus pyrrolidine derivatives possessing P-N bonds are a promising yet underexplored class of compounds.
Abdullaeva D.S., Burilov A.R., Turmanov R.A., Smolobochkin A.V., Pudovik M.A., Gazizov A.S.   +5 more
core  

A Versatile Method for the Facile Synthesis of Enantiopure trans- and cis-2,5-Disubstituted Pyrrolidines

, 2016
Treatment of (2S)-1-O-benzylglycerol-2,3-bistriflate (2) with the trilithiated species of chiral building blocks 5−7 provided 2,3,5-trisubstituted pyrrolidines that were subjected to reductive desulfonylation to give trans-2,5-disubstituted pyrrolidines ...
Qian Wang (32718), Pierre Potier (2193799), N. André Sasaki (2654302), Claude Riche (2716564)   +3 more
core   +1 more source

AIEgen Targets the STAT3‒SUCLG2 Axis to Regulate Metabolism for Colorectal Cancer Theranostics

Aggregate, Volume 7, Issue 6, June 2026.
In CRC, TPA‐FB directly binds to STAT3 and blocks its phosphorylation. It reduces SUCLG2 expression, disrupts mitochondrial function and modulates protein succinylation. Our work highlights that targeting oncogenic STAT3, TPA‐FB rewires metabolism and inhibits CRC progression.
Shaomin Zou, Dan Zhong, Song Xiang, Jieping Zhang, Ruijia Zhang, Ziqing Yang, Manqi Meng, Kuiheng Chen, Ling Fang, Bart Ghesquiere, Hai‐Tao Feng, Ben Zhong Tang, Lekun Fang   +12 more
wiley   +1 more source

Selective Ring-Opening of N-Alkyl Pyrrolidines with Chloroformates to 4-Chlorobutyl Carbamates

, 2018
Our study shows that among aza-heterocycles of various ring sizes, including aziridines, azetidines, pyrrolidines, and piperidines, only N-alkyl pyrrolidines undergo competitive reaction pathways with chloroformates to yield N-dealkylated pyrrolidines ...
김준수
core   +1 more source

Electronic Smoking Devices Among University Students: Usage Patterns and Chemical Composition of Inhaled Substances

Analytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT This study investigated the prevalence of electronic smoking device (ESD) use and its associated behavioural and chemical risks among university students in Bahia, Brazil. A cross‐sectional survey was conducted with 355 students from public and private institutions through an online questionnaire between April and May 2023. Among participants,
Eduard F. Valenzuela, Raffael Silva Santos Almeida, Ivana Ferreira Simões, Aline Gonçalves Miranda, Magno Oliveira Ramos, Roberto Rodrigues Bandeira Tosta Maciel, Fernanda Warken Rosa, Aníbal de Freitas Santos Júnior   +7 more
wiley   +1 more source

Copper Joins the Monoelectronic Game: Leveraging the CuI Potential for SET‐, XAT‐, and HAT‐Driven Catalytic Organic Synthesis

ChemCatChem, Volume 18, Issue 11, 15 June 2026.
This review surveys the emerging role of copper(I) catalysis in sustainable synthesis, highlighting its exceptional capacity for monoelectronic processes. By examining the strategies based on electron, halogen, and hydrogen transfer processes (SET, XAT, and HAT, respectively), we outline key reactivity trends, design principles, and the synthetic ...
Antonio Torres‐Calis, Juventino J. García   +1 more
wiley   +1 more source

Method for Reductive N‐Alkylation of a Secondary Amine With an Aldehyde at Room Temperature Through Utilization of an Imine Reductase

Chemistry–Methods, Volume 6, Issue 6, June 2026.
An organic‐synthetic method for smooth N‐alkylation of a secondary amine with an aldehyde as reagents and glucose as a reducing agent in aqueous medium has been developed, exemplified for the N‐benzylation of 2‐methylpyrrolidine. This transformation proceeds through enzyme catalysis with an imine reductase as a biocatalyst and a glucose dehydrogenase ...
Kateryna Zelenska, Harald Gröger
wiley   +1 more source