Results 141 to 150 of about 29,047 (251)

Light-Driven Stereoselective Aryl Bisenone Cycloaddition: A Metal-Free Strategy for the Construction of Functionalized Pyrrolidines and Tetrahydrofurans

SynOpen
Francesca Franco, Tommaso Benettin, Fabrizio Medici, Sergio Rossi, Simonetta Resta, Alessandra Puglisi, Maurizio Benaglia   +6 more
doaj   +1 more source

Synthesis of 1,3-Disubstituted 3-Azabicyclo[3.2.0]heptane Libraries for Fragment-Based Drug Discovery. [PDF]

Org Lett
Janssen MACH, van der Vorm JWA, Rappard R, Bijleveld B, Dekker T, Wijtmans M, de Esch IJP, Blanco-Ania D, Rutjes FPJT.   +8 more
europepmc   +1 more source

Synthesis of 25-Disubstituted 3-(Phenylsulfonyl)pyrrolidines via 5-i Endo- Trig Cyclisation Reactions

, 1997
Reaction of lithiated (phenylsulfonyl)methane with enantiomerically pure N-diphenylphosphinylaziridines gives adducts 4, which may be acylated at the sulfone a-position by further lithiation and reaction with non-enolisable acid chlorides, giving ketones
Donald Craig (2673391), Gareth J Rowlands (16065887), Philip S Jones (16110725)   +2 more
core  

Visible‐Light Cobalt‐Catalyzed Synthesis of Aroyl Amides From Arylazo Sulfones

Advanced Synthesis &Catalysis, Volume 368, Issue 20, 16 October 2026.
Blue Light and Cobalt Catalysis for Synthesis! A versatile strategy that combines photoactive arylazo sulfones as substrates and Co2(CO)8 as a catalyst for the preparation of aromatic amides is presented herein. A versatile strategy leveraging the peculiar reactivity of arylazo sulfones as substrates bearing dyedauxiliary groups in arylation processes,
Komal Jaiswal, Lorenzo Di Terlizzi, Burkhard König, Maurizio Fagnoni, Stefano Protti   +4 more
wiley   +1 more source

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova, Vladimir N. Belov, Constanze Schmidt, Stephan E. Lehnart   +3 more
wiley   +1 more source

Nickel-Catalyzed Enantioconvergent Arylation of Unactivated Cyclic Electrophiles: Asymmetric Synthesis of 3-Substituted Pyrrolidines. [PDF]

Angew Chem Int Ed Engl
Wong THM, Tong X, Fu GC.
europepmc   +1 more source

Synthesis of heterocycles based on azomethine ylides from α-amino acids (or amines) and carbonyl compounds. [PDF]

Beilstein J Org Chem
Berezhnaya EV, Ponyaev AI, Boitsov VM, Stepakov AV.   +3 more
europepmc   +1 more source

Facile synthesis of <i>trans</i> racemic 1,4-diaryl substituted, proline esters <i>via</i> Ugi multicomponent reaction. [PDF]

RSC Adv
Polineni SK, Sathya Shanker P, Anthappan TK, Nair VA.   +3 more
europepmc   +1 more source

Synthesis of 4- and 5-membered fluorine-stabilised semi-saturated heterocycles via alkylidene carbenes. [PDF]

Nat Commun
Harvey Randle E, Sedikides AT, Lefranc J, Lennox AJJ.   +3 more
europepmc   +1 more source

Photoredox-enabled late-stage functionalization of pyrrolidines in batch and flow: rapid access to benzothiazole hybrids as a new class of cholinesterase inhibitors. [PDF]

RSC Adv
Filipović A, Vučkovski M, Mićović D, Bondžić AM, Bondžić BP.   +4 more
europepmc   +1 more source