Results 101 to 110 of about 29,810 (265)

A DFT Study on the Mechanism of Selective Formation of Substituted Azepines From 1‐Azabutadienes and Cyclopropanes

Chemistry – A European Journal, EarlyView.
The origin of the unusual regioselectivity in the Mg‐catalyzed cyclization of azadiene‐type imines with cyclopropanes is elucidated by DFT calculations. Although five‐membered rings are typically favored, energy decomposition analysis reveals that severe steric congestion induces a highly distorted transition state, rendering the five‐membered pathway ...
Ryo Kobayashi, Chao Wang, Shuto Kosuge, Yuji Matsuya, Kenji Sugimoto, Keiichi Hirano   +5 more
wiley   +1 more source

Stereoselective Ag-Catalyzed 1,3-Dipolar Cycloaddition of Activated Trifluoromethyl-Substituted Azomethine Ylides [PDF]

, 2016
This is the peer reviewed version of the following article: Chemistry – A European Journal 22.14 (2016): 4952 - 4959, which has been published in final form at http://doi.org/10.1002/chem.201504869. This article may be used for non-commercial purposes in
Adrio, Adrio, Arai, Bai, Beausoleil, Begue, Belhomme, Bezdudny, Bonin, Burger, Castello, Castelló, Chaume, Cheng, Corbett, Dai, Dai, Daly, Das, Erickson, Fritz, Fujiwara, González-Esguevillas, Gouverneur, Hashimoto, He, Huang, Khangarot, Kuhnert, Laduron, Li, Li, Li, Llamas, Ma, McAlpine, Michael, Müller, Nájera, O'Hagan, Ojima, Padilla, Pandey, Pascual-Escudero, Pellissier, Pinho e Melo, Potowski, Purser, Pyne, Roughley, Sato, Schlosser, Song, Stanley, Sun, Tanaka, Tran, van Niel, Whitby, Yan, Yang, Yuan, Zhao   +62 more
core   +2 more sources

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, EarlyView.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis

Beilstein Journal of Organic Chemistry, 2008
Tandem deoxygenation–neophyl-type radical rearrangement–electrophile trapping using xanthates from 7-azabenzonorbornadienes gives 3-exo-substituted 2-aza-5,6-benzonorbornenes, which in some cases undergo isomerisation to (aminomethyl)indenes.
David M. Hodgson, Leonard H. Winning
doaj   +1 more source

Efficient Synthesis of Fully Substituted Pyrrolidine-Fused 3-Spirooxindoles via 1,3-Dipolar Cycloaddition of Aziridine and 3-Ylideneoxindole

Molecules, 2016
Drug-like spirocyclic scaffolds have been prepared by fusing fully functionalized pyrrolidine with oxindoles in an approach based on 1,3-dipolar cycloaddition.
Wen Ren, Qian Zhao, Chuan Zheng, Qiong Zhao, Li Guo, Wei Huang   +5 more
doaj   +1 more source

Regio- and Stereoselective Aminopentadienylation of Carbonyl Compounds [PDF]

, 2014
A simple and robust protocol is detailed for the preparation of enantioenriched α-substituted (1,4-pentadien-3-yl)amine derivatives. The methodology involves the addition of an in situ formed pentadienyl indium reagent to chiral tert-butylsulfinimines ...
Bagdatli, Emine, Bosque, Irene, Foubelo, Francisco, Gonzalez-Gomez, Jose C.   +3 more
core   +2 more sources

Hydroxylated Pyrrolidines. Enantiospecific Synthesis of all-cis 2,3,4,5-Substituted Pyrrolidine Derivatives from Serine

The Journal of Organic Chemistry, 2002
We report the enantiospecific synthesis of the sterically congested all-cis 2,3,4,5-substituted pyrrolidines 4, 5, and 6, from either D- or L-serine. Hemiaminal intermediate 13 is converted to the fully substituted pyrrolidine 15 by way of a tandem Wittig-Michael reaction.
Verma, S.K., Atanes, M.N., Busto, J.H., Thai, D.L., Rapoport, H.   +4 more
openaire   +4 more sources

Enzymatic Prenylation of Proteins and Peptides: From Cysteine S‐Prenylation to Tryptophan‐Selective Biocatalysis

Chemistry – A European Journal, EarlyView.
This review highlights biocatalytic prenylation as a versatile strategy for tailoring the functional properties of peptides and proteins. By comparing branched isoprenoids with linear lipids, we illustrate how specific prenyl architectures modulate the behaviors of lipidated proteins within membrane environments.
Daisuke Fujinami, Hikari Ozawa, Sohei Ito   +2 more
wiley   +1 more source

Identification and Characterization of the Designer Opioid N‐Pyrrolidino Fluetonitazene in Nasal Spray

Drug Testing and Analysis, EarlyView.
N‐Pyrrolidino fluetonitazene, a synthetic opioid, was identified and characterized in a nasal spray using GC‐MS, LC‐QTOF‐MS, NMR and FT‐IR. ABSTRACT Detection of drugs in non‐biological samples serves as a fundamental basis for identifying emerging trends in the field of new psychoactive substances and provides valuable information for optimizing ...
Fabian Picht, Valentin Cepus, Rona Hohlfeld, Julian Klingbeil, Marco Weber   +4 more
wiley   +1 more source

Redox-neutral α-functionalization of pyrrolidines: facile access to α-aryl-substituted pyrrolidines. [PDF]

RSC Adv
Using a quinone monoacetal as the oxidant and DABCO as the base, we report the one-step synthesis of α-aryl-substituted pyrrolidines from pyrrolidine. The reaction of pyrrolidine and quinone monoacetal in 2,2,2-trifluoroethanol afforded octahydro-dipyrroloquinoline in high yield.
Tian FX, Liu FF, Wei J, Xiao JX, Qu J.
europepmc   +3 more sources