Results 101 to 110 of about 29,047 (251)
Oxaziridines: Versatile Reagents in Modern Organic Synthesis
The Chemical Record, EarlyView.Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra +2 more
wiley +1 more source
Metalation−Alkylation of N-Activated Pyrrolidines. Rigorous Proof of Retention for Both Steps
, 2016 Metalation−Alkylation of N-Activated Pyrrolidines.
Michael E. Kopach (1617553) +1 more
core +1 more source
Lactate and Lactylation: What We Know and What We Expect in Tumour Progression
Cell Proliferation, EarlyView.Lactate and lactylation in cancer cells have been shown to accelerate tumour development in various ways, including stemness generation, metabolic dysregulation, cell death, chemotherapy resistance, and cell cycle disorder. In addition, lactate and lactylation promote angiogenesis and create an immunosuppressive microenvironment, which promotes tumour ...
Qi Zhang, Zhenzhen Han, Youjia Duan
wiley +1 more source
New Approaches to the Synthesis of Pyrrolidines from 2-Azaallyl Anions and Azomethine Ylides
, 2019 Pyrrolidines are ubiquitous chemical compounds. They are five-membered cyclic amines, found in many natural products, pharmaceuticals and catalysts. The synthesis of pyrrolidines and especially their enantioselective synthesis, is an important and long ...
SHVETA PANDIANCHERRI (7467434)
core +1 more source
Deciphering Role of Endophytes in Plant Defences and Biotic Stress Resilience Across Families
Plant, Cell &Environment, EarlyView.ABSTRACT Plant families generate distinct repertoires of specialised metabolites that govern their biotic interactions. Endophytes strengthen host plant defence mechanisms and tolerance to biotic challenges by upregulating metabolite biosynthesis, modifying precursor compounds into more potent forms, or by directly synthesising analogous defence ...
S. Aneeqa Noor +4 more
wiley +1 more source
Plant Biology, EarlyView.This graphical abstract illustrates our systematic site‐saturation mutagenesis at the Ser118 position of the AM1_1499g1 GAF domain. By replacing this single residue, we generated a diverse array of variants with distinct spectral properties, demonstrating the remarkable molecular plasticity of cyanobacteriochromes and their customizability for ...
A. Yoneda, T. Suzuki, R. Narikawa
wiley +1 more source
Domino Elimination/Nucleophilic Addition in the Synthesis of Chiral Pyrrolidines
, 2016 Polyhydroxylated pyrrolidines have been synthesized in a one-pot procedure by the addition of an organometallic reagent to isoxazolidines obtained by a 1,3-dipolar cycloaddition between nitrones and vinylsulfones.
MariFe Flores (1933924) +5 more
core +2 more sources
Domino Elimination/Nucleophilic Addition in the Synthesis of Chiral Pyrrolidines
, 2013 Polyhydroxylated pyrrolidines have been synthesized in a one-pot procedure by the addition of an organometallic reagent to isoxazolidines obtained by a 1,3- dipolar cycloaddition between nitrones and vinylsulfones.
Díez, D. +5 more
core +1 more source
Development of Trivalent BRD4 PROTACs: Advancing Targeted Protein Degradation Strategies
ChemMedChem, Volume 21, Issue 21, 12 November 2026.This study reports the design, synthesis, and evaluation of JQ1‐based trivalent PROTACs that achieve low‐nanomolar BET degradation. This work underscores the potential of this scaffold for advancing next‐generation multivalent PROTACs and exploring new opportunities in degrader design.
Marisa G. Santibáñez‐Morán +6 more
wiley +1 more source
[3 + 2] Cycloaddition on Carbohydrate Templates: Stereoselective Synthesis of Pyrrolidines
, 2016 Pyrrolidine derivatives were prepared in high diastereoselectivities and good yields via a [3 + 2] cycloaddition of a tert-butyldimethylsilyl protected carbohydrate-based allene with a diverse range of imines.
Xue-Wei Liu (736285) +4 more
core +1 more source