Results 91 to 100 of about 26,509 (243)

Facile, Regio- and Diastereoselective Synthesis of Spiro-Pyrrolidine and Pyrrolizine Derivatives and Evaluation of Their Antiproliferative Activities

Molecules, 2014
A number of novel spiro-pyrrolidines/pyrrolizines derivatives were synthesized through [3+2]-cycloaddition of azomethine ylides with 3,5-bis[(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones 2a–n.
Abdulrahman I. Almansour, Raju Suresh Kumar, Farzana Beevi, Amir Nasrolahi Shirazi, Hasnah Osman, Rusli Ismail, Tan Soo Choon, Brian Sullivan, Kellen McCaffrey, Alaa Nahhas, Keykavous Parang, Mohamed Ashraf Ali   +11 more
doaj   +1 more source

1,1‐Disubstituted Vinylbromides: Versatile Building Blocks for the Synthesis of Nitrogen‐Containing Heterocycles

European Journal of Organic Chemistry, EarlyView.
1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer, Jun Fang, Chonghuo Liu, Guillaume Lefèvre, Gérard Guillamot, Phannarath Phansavath, Virginie Ratovelomanana‐Vidal   +6 more
wiley   +1 more source

One-Pot Synthesis of N-(Phosphorylmethyl)Pyrrolidines via Acid-Catalyzed Cascade Elimination/Cyclization/Friedel–Crafts Reaction

, 2020
International audienceThe efficient approach to novel water-soluble 2-aryl-substituted N-(phosphorylmethyl)pyrrolidines via acid-catalyzed elimination/cyclization/Friedel–Crafts reaction sequence of {[(4,4-diethoxybutyl)amino]methyl}phosphonates is ...
Vagapova, Liliya, Litvinov, Igor, Pudovik, Mikhail, Voronina, Julia, Gazizov, Almir, Pirat, Jean-Luс, Mahrous, Essan, Virieux, David, Burilov, Alexander, Matylitskii, Kiryll   +9 more
core   +1 more source

Synthesis of Novel C‐Acyl‐Glycosyl Sulfonamides via Pd‐Catalyzed Carbonylative Coupling

European Journal of Organic Chemistry, EarlyView.
A Pd‐catalyzed carbonylative coupling of 1‐iodo‐glycals with diverse sulfonamides using Mo(CO)6 enables efficient access to C‐acyl‐glycosyl sulfonamides.This robust and versatile strategy delivers novel glycoside derivatives in good to excellent yields, highlighting their potential for drug discovery.
João A. F. Silva, Mônica F. Z. J. Toledo, Flávia Manarin, João H. de Araujo‐Neto, Milene M. Hornink, Hélio A. Stefani   +5 more
wiley   +1 more source

Radical cascades using enantioenriched 7-azabenzonorbornenes and their applications in synthesis

Beilstein Journal of Organic Chemistry, 2008
Tandem deoxygenation–neophyl-type radical rearrangement–electrophile trapping using xanthates from 7-azabenzonorbornadienes gives 3-exo-substituted 2-aza-5,6-benzonorbornenes, which in some cases undergo isomerisation to (aminomethyl)indenes.
David M. Hodgson, Leonard H. Winning
doaj   +1 more source

Efficient Synthesis of Fully Substituted Pyrrolidine-Fused 3-Spirooxindoles via 1,3-Dipolar Cycloaddition of Aziridine and 3-Ylideneoxindole

Molecules, 2016
Drug-like spirocyclic scaffolds have been prepared by fusing fully functionalized pyrrolidine with oxindoles in an approach based on 1,3-dipolar cycloaddition.
Wen Ren, Qian Zhao, Chuan Zheng, Qiong Zhao, Li Guo, Wei Huang   +5 more
doaj   +1 more source

Reactions affording novel pyrrolidines catalysed by palladium [PDF]

Pyrrolidines are privileged motifs in drug discovery, ranked among the top five most common non-aromatic N-heterocycles and featured in 37 FDA-approved drugs.
Robinson, Joshua, Doulcet, Julien
core  

Redox Properties of Catalytically Generated Iminium Ions From α,β‐Unsaturated Aldehydes and Chiral Secondary Amines

European Journal of Organic Chemistry, EarlyView.
We present a rapid, operationally simple, and broadly applicable protocol for the catalytic formation and in situ electrochemical characterization of chiral a,b‐unsaturated iminium ions by cyclic voltammetry (CV). Using only 5 mol% of the aminocatalyst, we systematically measure the reduction potential of over 50 iminium intermediates, revealing how ...
Martí Gisbert, Paula Rodríguez, Xavier Companyó   +2 more
wiley   +1 more source

A New Synthesis of Pyrrolidines by Way of an Enantioselective Mannich/Diastereoselective Hydroamination Reaction Sequence

, 2016
A new two-step synthesis of highly substituted pyrrolidines has been developed. Chiral silane Lewis acid promoted enantioselective Mannich reactions of silyl ketene imines with acylhydrazones may be used to access bishomoallylic benzoic hydrazides that ...
James L. Leighton (1308837), Jenny M. Baxter Vu (2178562)   +1 more
core   +2 more sources

Multivalent pyrrolidines acting as pharmacological chaperones against Gaucher disease

International audienceA concise asymmetric synthesis of clickable enantiomeric pyrrolidines was achieved using Crabbé-Ma allenation. The synthesized iminosugars were grafted by copper–free strain-promoted alkyne-azide cycloaddition onto phosphorus ...
Rodriguez, Frédéric, Turrin, Cédric-Olivier, Lan Tran, My, Garcia, Virginie, Oukhrib, Abdelouahd, Ballereau, Stéphanie, Levade, Thierry, Borie-Guichot, Marc, Baudoin-Dehoux, Cécile, Génisson, Yves   +9 more
core   +1 more source