Results 91 to 100 of about 29,047 (251)

Efficient Synthesis of Fully Substituted Pyrrolidine-Fused 3-Spirooxindoles via 1,3-Dipolar Cycloaddition of Aziridine and 3-Ylideneoxindole

Molecules, 2016
Drug-like spirocyclic scaffolds have been prepared by fusing fully functionalized pyrrolidine with oxindoles in an approach based on 1,3-dipolar cycloaddition.
Wen Ren, Qian Zhao, Chuan Zheng, Qiong Zhao, Li Guo, Wei Huang   +5 more
doaj   +1 more source

Acid-Catalyzed Cyclization of Vinylsilanes Bearing an Amino Group. Stereoselective Synthesis of Pyrrolidines¹

, 2016
In the presence of an acid catalyst, vinylsilanes 1 bearing an amino group protected by an electron-withdrawing group were smoothly cyclized to 2-(silylmethyl)pyrrolidines 2.
Tatsuyuki Takahashi (2982642), Akira Hosomi (2340361), Katsukiyo Miura (1748458), Takeshi Hondo (1960309), Takahiro Nakagawa (2982639)   +4 more
core   +1 more source

Pyrene‐linked heterocyclic pyrazoles: Synthesis, antimicrobial screening, and in silico molecular insights

Smart Molecules, EarlyView.
A series of novel pyrene‐linked heterocyclic pyrazoles were synthesized and structurally characterized. The compounds were evaluated for antimicrobial activity against selected bacterial and fungal strains, showing promising inhibitory effects. Molecular docking studies provided insights into binding interactions and structure–activity relationships ...
Dinkal V. Kasundra, Paresh N. Patel
wiley   +1 more source

Stereoselective Monoamine Oxidase-Catalyzed Oxidative Aza-Friedel–Crafts Reactions of meso-Pyrrolidines in Aqueous Buffer

, 2016
: We disclose the highly diastereoselective combination of monoamine oxidase-catalyzed oxidation of meso-pyrrolidines and aza-FriedelCrafts reactions in aqueous buffer to give valuable enantioenriched 2-substituted pyrrolidines in a formal double C[BOND ...
Bechi, Beatrice, Peruch, O., Oppelaar, B., Orru, Romano V.A., Turner, N.J., de Graaff, C., Turner, Nicholas J., Oppelaar, Barry, Orru, R.V.A.; id_orcid, Orru, Romano V A, Ruijter, E.; id_orcid, Vandervelde, M.L., Turner, Nicholas; id_orcid, Ruijter, Eelco, de Graaff, C, Vande Velde, C. M. L, Bechi, B., de Graaff, Corien, Oppelaar, B, P\ue9ruch, Olivier, Péruch, O, Vande Velde, Christophe M.L.   +21 more
core   +1 more source

Recent advances in polymeric chemically amplified positive resists: Materials and design strategies

Smart Molecules, EarlyView.
This review summarizes recent advances in the molecular design of positive chemically amplified resists, focusing on photoacid generators and polymer architectures. Key strategies for enhancing sensitivity—including self‐amplification effects, copolymerization of sensitive monomers, controlled polymerization, and photosensitized chemically amplified ...
Litao Zhou, Haoyuan Li, Jianhua Zhang, Hanshen Xin   +3 more
wiley   +1 more source

Molecular Structures of Enantiomerically-Pure (S)-2-(Triphenylsilyl)- and (S)-2-(Methyldiphenylsilyl)pyrrolidinium Salts

Inorganics, 2017
Silyl-substituted pyrrolidines have gained increased interest for the design of new catalyst scaffolds. The molecular structures of four enantiomerically-pure 2-silylpyrrolidinium salts are reported.
Jonathan O. Bauer, Carsten Strohmann
doaj   +1 more source

Modular Synthesis of α‐Quaternary Pyrrolines by Pyridoxal‐Catalyzed Sequential Reactions With Precise Chirality Relay

Transformative Chemistry, EarlyView.
Direct asymmetric α‐C conjugate addition of aminoacetonitrile enabled by carbonyl/iminium double activation, together with subsequent electrophilic functionalization, offers a one‐pot, two‐step modular strategy for synthesizing chiral α‐quaternary pyrrolines with precise chirality relay and high structural diversity.
Xingdie Yang, Pengwei Ji, Liang Liu, Tongyin Chen, Siqi Liu, Wen‐Wen Chen, Baoguo Zhao   +6 more
wiley   +1 more source

Selective Ring-Opening of N-Alkyl Pyrrolidines with Chloroformates to 4-Chlorobutyl Carbamates

, 2018
Our study shows that among aza-heterocycles of various ring sizes, including aziridines, azetidines, pyrrolidines, and piperidines, only N-alkyl pyrrolidines undergo competitive reaction pathways with chloroformates to yield N-dealkylated pyrrolidines ...
김준수
core   +1 more source

Electrochemical Reductive β‐Arylation and Alkenylation of α‐Branched Acroleins by Primary Amine/Nickel Dual Catalysis

Transformative Chemistry, EarlyView.
A synergistic primary amine/nickel catalysis under electrochemical conditions was developed for cathodic β‐arylation and alkenylation of α‐branched acroleins. The reaction proceeds through β‐enaminyl radicals generated by cathodic reduction of an iminium ion allowing smooth coupling with aryl‐ or alkenyl‐Ni(II) species.
Yingdong Duan, Fanzhu Zeng, Qifeng Lin, Sanzhong Luo   +3 more
wiley   +1 more source

Cycloaddition/annulation strategies for the construction of multisubstituted pyrrolidines and their applications in natural product synthesis

, 2018
Pyrrolidines are privileged substructures of numerous bioactive natural products and drugs.
Yilin Ye, Yandong Zhang, Jundong Li
core   +1 more source