Results 221 to 230 of about 17,768 (339)

Thermal elimination of carbonyl sulfide from O-aryl thionocarbonates of pyrrolidine-, piperidine-, and tetrahydrothiophene-2-ethanol.

, 1990
Satomi SAKANOUE, Shinya HARASAWA, Naoki Yamazaki, Ryuji Yoneda, Takushi Kurihara   +4 more
openalex   +2 more sources

An Enhanced Metabolization Protocol for In Vitro Genotoxicity Assessment of N‐Nitrosamines in Mammalian Cells

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT N‐Nitrosamines (NAs) are probable human carcinogens and were detected as impurities in pharmaceuticals, which led to a concern for human health. NAs require metabolic activation before they become mutagenic, and not all NAs are mutagenic since their reactivity is related to their structure.
M. E. Geijer, A. M. Gernaat, N. Moelijker, I. Brandsma, G. Hendriks   +4 more
wiley   +1 more source

Bifunctional Imine Reductase Cascades for the Synthesis of Saturated N-Heterocycles. [PDF]

ACS Catal
Ramsden JI, Zucoloto da Costa B, Heath RS, Marshall JR, Derrington SR, Mangas-Sanchez J, Montgomery SL, Mulholland KR, Cosgrove SC, Turner NJ.   +9 more
europepmc   +1 more source

Electrochemical hydrogen isotope exchange of amines controlled by alternating current frequency. [PDF]

Faraday Discuss, 2023
Behera N, Gunasekera D, Mahajan JP, Frimpong J, Liu ZF, Luo L.   +5 more
europepmc   +1 more source

Mass Spectra of Bis-Amide Pyrrolidine Alkaloids.

, 1994
Naoto Senda, Hisamasa WAKAYAMA, Tomoyuki Fujita, Tomomi Bando, Kenichi Shizukuishi, H. Yamaoka, Mitsuru Nakayama   +6 more
openalex   +2 more sources

Synthesis of Substituted Pyrrolidines

, 2016
The task of medicinal chemists in a drug discoveryproject is to synthesize/design analogues to the screening hits, simultaneouslyincreasing target potency and optimizing the pharmacological properties.  This requires a wide selection of moleculesto be synthesized, where both synthetic feasibility and price of startingmaterials are of great importance ...
openaire   +1 more source

The Impact of Augmented Renal Clearance on the Pharmacokinetics of Levetiracetam in Critically Ill Patients: A Literature Review

The Journal of Clinical Pharmacology, EarlyView.
Abstract Levetiracetam is an antiseizure medication (ASM) that has several advantages over other ASMs, such as dose‐proportional pharmacokinetics, high bioavailability, and minimal drug interactions. The drug is primarily eliminated through the kidneys. Therefore, dose adjustments are necessary in patients with renal impairment or patients experiencing
Maged Kharouba, Asma Aboelezz, Janice Y. Kung, Sherif Hanafy Mahmoud   +3 more
wiley   +1 more source

Development of a Synthetic Route to Vonoprazan via Atom Transfer Radical Cyclization. [PDF]

J Org Chem
Ojima KI, Imaizumi R, Komori T, Nishikawa T, Doi N, Nishiguchi S.   +5 more
europepmc   +1 more source

Pyrrolidine dithiocarbamate inhibits immunostimulant-induced tetrahydrobiopterin synthesis in rat vascular smooth muscle

, 1996
Yoshiyuki Hattori, Nobuo Nakanishi, Kikuo Kasai, Shin-Ichi Shimoda, Steven S. Gross   +4 more
openalex   +1 more source

Stereocontrolled and time-honored access to piperidine- and pyrrolidine-fused 3-methylenetetrahydropyrans using lactam-tethered alkenols. [PDF]

RSC Adv
Beng TK, Anosike IS, Kaur J.
europepmc   +1 more source