Results 281 to 290 of about 17,768 (339)

Skeletal Rearrangements of Amides via Breaking Inert Bonds

Chemistry – A European Journal, Volume 31, Issue 25, May 5, 2025.
This review highlights advances in amide skeletal rearrangement reactions over the past two decades, categorized by the initial bond cleavages: C─N bond cleavage, C─C bond cleavage, and C═O bond activation. It summarizes emerging strategies, mechanistic insights, and synthetic applications, providing a focused perspective on recent developments in this
Rui Zhang, Guangbin Dong
wiley   +1 more source

Retreatment of patients with chronic hepatitis C, subtype 3a, and cirrhosis, who previously failed a regimen containing second-generation NS5A inhibitors with sofosbuvir + glecaprevir/pibrentasvir and ribavirin for 16-24 weeks. [PDF]

J Virol
Fedorchenko SV, Klimenko Z, Martynovich T, Solianyk I, Suprunenko T.   +4 more
europepmc   +1 more source

Ultrasound‐Assisted Microcontinuous Process Facilitates the Selective Deuteration of Steroid Hormones

Journal of Labelled Compounds and Radiopharmaceuticals, Volume 68, Issue 5-6, May 2025.
Herein, we demonstrate a practical and efficient approach to synthesize 12 deuterated steroid hormones with up to 98% selectivity and 99% d‐incorporation under an ultrasound‐assisted microcontinuous process. Our protocol enables rapid, inexpensive, and sustainable gram‐scale synthesis, facilitated by the reuse of deuterated solvents via molecular ...
Dan Wang, Xin Lv, Fang Wei
wiley   +1 more source

Impact of elexacaftor/tezacaftor/ivacaftor (ETI) on the prescription refill rate (PRR) for inhaled medications in people with CF: an Italian multicenter analysis. [PDF]

Respir Res
Gramegna A, Cimino G, Cipolli M, Gandini G, Calderazzo MA, Profiti A, Piedepalumbo F, Blasi F.   +7 more
europepmc   +1 more source

Pyrrolidine dithiocarbamate up-regulates the expression of the genes encoding the catalytic and regulatory subunits of gamma-glutamylcysteine synthetase and increases intracellular glutathione levels.

, 1999
Angela C. Wild, Ríona Mulcahy
openalex  

G9a an Epigenetic Therapeutic Strategy for Neurodegenerative Conditions: From Target Discovery to Clinical Trials

Medicinal Research Reviews, Volume 45, Issue 3, Page 985-1015, May 2025.
ABSTRACT This review provides a comprehensive overview of the role of G9a/EHMT2, focusing on its structure and exploring the impact of its pharmacological and/or gene inhibition in various neurological diseases. In addition, we delve into the advancements in the design and synthesis of G9a/EHMT2 inhibitors, which hold promise not only as a treatment ...
Aina Bellver‐Sanchis, Marta Ribalta‐Vilella, Alba Irisarri, Pinky Gehlot, Bhanwar Singh Choudhary, Abhisek Jana, Vivek Kumar Vyas, Deb Ranjan Banerjee, Mercè Pallàs, Ana Guerrero, Christian Griñán‐Ferré   +10 more
wiley   +1 more source

Heterophyllin B: Combining Isotropic and Anisotropic NMR for the Conformational Analysis of a Natural Occurring Cyclic Peptide

Magnetic Resonance in Chemistry, Volume 63, Issue 5-6, Page 417-423, May-June 2025.
A minimal conformational ensemble of cyclic peptide heterophyllin B is presented at the density functional theory accuracy using isotropic and anisotropic NMR. ABSTRACT Heterophyllin B is a natural occurring cyclic peptide with diverse attributed bioactivities.
Anton F. Ketzel, Yang Hu, Xiao‐Lu Li, Jiaqian Li, Xinxiang Lei, Han Sun   +5 more
wiley   +1 more source

Entry to 2-aminoprolines via electrochemical decarboxylative amidation of <i>N</i>‑acetylamino malonic acid monoesters. [PDF]

Beilstein J Org Chem
Koleda O, Sadauskis J, Antonenko D, Treijs EJ, Steberis RD, Suna E.   +5 more
europepmc   +1 more source

Reactivity and basicity: insight into organocatalysis by secondary amines [PDF]

, 2019
An, Feng
core  

Computational Design, Synthesis, and Biological Assessment of Some Pyrrolo[3,4‐c]Pyrroles Targeting Mycobacterium Tuberculosis

ChemistrySelect, Volume 10, Issue 17, May 5, 2025.
A new set of spirooxindole‐ and spiroindenoquinoxaline‐derived pyrrolo[3,4‐c] pyrroles has been synthesized through atom‐economic one‐pot multicomponent reactions. Based on the results, compounds 4b and 5a demonstrated promising Glide scores and exhibited strong binding affinity with decaprenylphosphoryl‐β‐D‐ribofuranose oxidoreductase.
Mathiyazhagan Lavanya, Rajamanikandan Sundararaj, Kailasam Saravana Mani, Krishnakumar Balu, Mani Durai, Perwez Alam, Priya SD, Mathivanan Durai, Young Ho Ahn   +8 more
wiley   +1 more source