Brivaracetam Combined With Topiramate at Low Doses Alleviates Neurobehavioral Deficits and Oxidative Stress in a Chemoconvulsant Kindled Seizure Model. [PDF]
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Treatment of epilepsy using newer antiseizure medications: A retrospective cohort study of prescription patterns in Sweden 2013-2022. [PDF]
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Effectiveness and safety of early add-on therapy with brivaracetam in patients with poorly controlled focal seizures in routine clinical practice: BRIV-add study. [PDF]
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Coupling Nitrogenous Organic Wastewater Treatment and Biorefinery via N-Cycling Bacterium. [PDF]
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Exploring the influence of synaptic density and anxiety on pain perception: evidence from a [11C]UCB-J positron emission tomography imaging study. [PDF]
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Safety, Tolerability, and Efficacy of Adjunctive Brivaracetam in Japanese and Chinese Patients with Focal-Onset Seizures: Interim Analysis of a Phase 3 Open-Label Extension Trial. [PDF]
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Efficacy and safety of Brivaracetam as adjunctive therapy in pediatric epilepsy: A systematic review and meta-analysis. [PDF]
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Structural analysis of pyrrolidinones
Acta Crystallographica Section C Crystal Structure Communications, 2000In the course of a study on pyrrolidinones, the crystal structures of four compounds, namely, methyl N-[(4-methoxyphenyl)(3,4,5-trimethoxyphenyl)methyl]pyroglutamate, C23H27NO7, methyl N-[naphthyl-(3,4,5-trimethoxyphenyl)methyl]pyroglutamate diacetyl peroxide, C26H27NO6·-0.5C4H6O4, 5-(3,4,5-trimethoxyphenyl)-1,2,3,11b-tetrahydro-
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Studies on pyrrolidinones. A convenient synthesis of 5‐cyano‐2‐pyrrolidinone derivatives
Journal of Heterocyclic Chemistry, 1986AbstractThe reaction of 2‐pyrrolidinone‐5‐carboxamide (pyroglutamide) with trimethylchlorosilane and zinc chloride as a catalyst afford in one step a 91% yield of N‐trimethylsilylpyroglutamic acid nitrile whose acylation gives N‐acyl compounds 2b,c.
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AbstractPyroglutamid (I) wird zu (II) silyliert und dann mit Zinkchlorid über (III) zum 5‐Cyan‐2‐pyrrolidinon (IVa) desilyliert.
B. RIGO, C. LESPAGNOL, M. PAULY
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