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Effectiveness and safety of early add-on therapy with brivaracetam in patients with poorly controlled focal seizures in routine clinical practice: BRIV-add study. [PDF]

open access: yesEpilepsia Open
Serrano-Castro PJ   +10 more
europepmc   +1 more source

Efficacy and safety of Brivaracetam as adjunctive therapy in pediatric epilepsy: A systematic review and meta-analysis. [PDF]

open access: yesNeurol Sci
Hassan MA   +8 more
europepmc   +1 more source
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Structural analysis of pyrrolidinones

Acta Crystallographica Section C Crystal Structure Communications, 2000
In the course of a study on pyrrolidinones, the crystal structures of four compounds, namely, methyl N-[(4-meth­oxy­phenyl)(3,4,5-tri­meth­oxy­phenyl)­methyl]­pyro­glut­amate, C23­H27­NO7, methyl N-[naphthyl-(3,4,5-tri­meth­oxy­phenyl)­methyl]­pyro­glut­amate diacetyl peroxide, C26­H27­NO6·-0.5C4H6O4, 5-(3,4,5-tri­meth­oxy­phenyl)-1,2,3,11b-tetrahy­dro-
Camus, Fabrice   +5 more
openaire   +3 more sources

Studies on pyrrolidinones. A convenient synthesis of 5‐cyano‐2‐pyrrolidinone derivatives

Journal of Heterocyclic Chemistry, 1986
AbstractThe reaction of 2‐pyrrolidinone‐5‐carboxamide (pyroglutamide) with trimethylchlorosilane and zinc chloride as a catalyst afford in one step a 91% yield of N‐trimethylsilylpyroglutamic acid nitrile whose acylation gives N‐acyl compounds 2b,c.
Benoǐt Rigo   +2 more
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ChemInform Abstract: Studies on Pyrrolidinones. A Convenient Synthesis of 5‐Cyano‐2‐pyrrolidinone Derivatives.

Chemischer Informationsdienst, 1986
AbstractPyroglutamid (I) wird zu (II) silyliert und dann mit Zinkchlorid über (III) zum 5‐Cyan‐2‐pyrrolidinon (IVa) desilyliert.
B. RIGO, C. LESPAGNOL, M. PAULY
openaire   +1 more source

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