Results 131 to 140 of about 2,735 (188)

Pyrrolidine-2,3-diones: heterocyclic scaffolds that inhibit and eradicate S. aureus biofilms.

Chem Commun (Camb)
Valdes-Pena MA, Ratchford A, Nie M, Schnabel LV, Pierce JG.   +4 more
europepmc   +1 more source

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Easy approach to 3-benzylimino-2-pyrrolidinones from 3-chloro-4-chloromethyl-2-pyrrolidinones

Tetrahedron Letters, 1999
Abstract 3-Benzylimino-2-pyrrolidinones can be prepared in good yield by heating 3-chloro-4-chloromethyl-2-pyrrolidinones, benzylamine and NaI in THF at 80°C. An endo -dehydrohalogenation followed by a SN 2 ′ substitution on the intermediate allyl chloride, and finally a shift of the exo -double bond to Δ 3 with attendant tautomerization ...
Franco Ghelfi, Emanuela Libertini, Luca Forti   +2 more
exaly   +3 more sources

Lewis Base‐Catalysed Enantioselective Radical Conjugate Addition for the Synthesis of Enantioenriched Pyrrolidinones [PDF]

Angewandte Chemie - International Edition, 2022
We report a catalytic asymmetric protocol for the preparation of chiral pyrrolidinones proceeding via a radical pathway. The chemistry exploits the combination of photoredox catalysis and Lewis base catalysis to realise the first example of asymmetric ...
Will C Hartley, Florian Schiel, Elena Ermini   +2 more
exaly   +3 more sources

3-Pyrrolidinones by Intramolecular Condensation

Journal of the American Chemical Society, 1964
James. Blake, Clyde D. Willson, Henry. Rapoport   +2 more
exaly   +2 more sources

Structural analysis of pyrrolidinones

Acta Crystallographica Section C Crystal Structure Communications, 2000
In the course of a study on pyrrolidinones, the crystal structures of four compounds, namely, methyl N-[(4-meth­oxy­phenyl)(3,4,5-tri­meth­oxy­phenyl)­methyl]­pyro­glut­amate, C23­H27­NO7, methyl N-[naphthyl-(3,4,5-tri­meth­oxy­phenyl)­methyl]­pyro­glut­amate diacetyl peroxide, C26­H27­NO6·-0.5C4H6O4, 5-(3,4,5-tri­meth­oxy­phenyl)-1,2,3,11b-tetrahy­dro-
Camus, Fabrice, Norberg, Bernadette, Legrand, Anne, Rigo, Benoit, Durant, François, Wouters, Johan   +5 more
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Studies on pyrrolidinones. A convenient synthesis of 5‐cyano‐2‐pyrrolidinone derivatives

Journal of Heterocyclic Chemistry, 1986
AbstractThe reaction of 2‐pyrrolidinone‐5‐carboxamide (pyroglutamide) with trimethylchlorosilane and zinc chloride as a catalyst afford in one step a 91% yield of N‐trimethylsilylpyroglutamic acid nitrile whose acylation gives N‐acyl compounds 2b,c.
Benoǐt Rigo, Charles Lespagnol, Marc Pauly   +2 more
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Unexpected reaction of β-cyclodextrin tosylate with pyrrolidinones

Carbohydrate Research, 2006
Substitution reactions of 6I-O-p-tolylsulfonylcyclomaltoheptaose with alkyl- and arylamines in 1-methyl-2-pyrrolidinone and various pyrrolidinones were investigated. An unexpected reaction of the tosyl group with pyrrolidinones was observed resulting in products deriving from nucleophilic attack by the lactam carbonyl oxygen and further opening of the ...
CUZZOLA A., PANELLI L., RAFFAELLI A., UCCELLO BARRETTA, GLORIA, BALZANO, FEDERICA, SALVADORI, PIERO   +5 more
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Optimization of pyrrolidinone based HIV protease inhibitors

Bioorganic & Medicinal Chemistry Letters, 2005
Optimization of P1-substituted pyrrolidinone based HIV protease inhibitors has yielded analogs with very potent antiviral activity.
Ronald G, Sherrill, C Webster, Andrews, William J, Bock, Ronda G, Davis-Ward, Eric S, Furfine, Richard J, Hazen, Randy D, Rutkowske, Andrew, Spaltenstein, Lois L, Wright   +8 more
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ChemInform Abstract: Studies on Pyrrolidinones. A Convenient Synthesis of 5‐Cyano‐2‐pyrrolidinone Derivatives.

Chemischer Informationsdienst, 1986
AbstractPyroglutamid (I) wird zu (II) silyliert und dann mit Zinkchlorid über (III) zum 5‐Cyan‐2‐pyrrolidinon (IVa) desilyliert.
B. RIGO, C. LESPAGNOL, M. PAULY
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1-Methyl-2-pyrrolidinone

2009
[872-50-4] C5H9NO (MW 99.15) InChI = 1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3 InChIKey = SECXISVLQFMRJM-UHFFFAOYSA-N (special solvent;1 source of enolates2) Alternate Names: NMP; N-methylpyrrolidone. Physical Data: mp −24.4 °C; bp 202 °C; d 1.030 g cm−3.
Peteris Trapencieris, Julie A. Pigza
openaire   +1 more source