Results 131 to 140 of about 2,072 (186)

Synthesis and reactions of 3‐pyrrolidinones

Journal of Heterocyclic Chemistry, 2008
Abstractmagnified imageThis review presents a survey of the synthetic methods and reactions of 3‐pyrrolidinonesI(R = H, alkyl, acyl, ester; R1= H, alkyl, cyano, ester, etc). 3‐Pyrrolidinones are synthetically versatiles substrate, as they can be used for synthesis of a large variety of heterocyclic compounds, such as indoles and 5‐deazapteroic acid ...
Fathy Abdel‐Kader Amer, Metwally Hammouda, Bakr Fathy Abdel‐Wahab, Abdel‐Aziz Sayed El‐Ahl   +3 more
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Percutaneous absorption of co-administered N-methyl-2-[14C]pyrrolidinone and 2-[14C]pyrrolidinone in the rat

Food and Chemical Toxicology, 1992
The percutaneous absorption has been investigated in rats of a mixture (3:2, w/w) of N-methyl-2-pyrrolidinone (NMP) and 2-pyrrolidinone (2-P), a combination intended for use as a vehicle in the formulation of an antimycotic drug to enhance skin penetration on dermal application, following co-administration of the two 14C-radiolabelled compounds by the ...
I, Midgley, A J, Hood, L F, Chasseaud, C J, Brindley, S, Baughman, G, Allan   +5 more
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Studies on Pyrrolidinones: Chemistry of Dimethoxytriazines

Synthesis, 2013
The synthesis of dimethoxytriazine-containing N-aryl substituted pyrrolidinones is realized for the first time. Three new modes of reactivity for these substrates possessing a 4,6-dimethoxy-1,3,5-triazine unit are discussed. Their treatment with acid leads to complete O-demethylation of the methoxy groups, while similar reaction in a basic medium leads
Alina Ghinet, Liliana Lucescu, Philippe Gautret, Souhila Oudir, Benoît Rigo, Dalila Belei, Elena Bîcu   +6 more
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Structure of the 2-Pyrrolidinone Monohydrate

Zeitschrift für Naturforschung B, 1999
The X-ray crystal structure of the 1:1 adduct shows a complicated network of water and 2-pyrrolidinone molecules where the carbonyl oxygen atom of 2-pyrrolidinone forms hydrogen bonds with protons of two separate water molecules and the NH proton of the 2- pyrrolidinone molecule interacts with the oxygen atom of a third water molecule.
Päivi Pirilä, Ilpo Mutikainen, Jouni Pursiainen   +2 more
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Disposition of N-Vinyl-2-Pyrrolidinone in the Rat

Drug and Chemical Toxicology, 1984
The disposition of N-[14C-vinyl]-2-pyrrolidinone was studied in male Sprague-Dawley rats following a single iv injection. Plasma levels of the intact compound dropped rapidly within the first 6 hours after dosing with a half life of 1.90 hours. Urinary excretion by 12 hours represented 74.9% of a 5 microCi dose while 18.7% was excreted into the bile by
J S, McClanahan, Y C, Lin, G A, Digenis
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Thermodynamic and spectroscopic properties of 2-pyrrolidinones. 2. Dielectric properties of 2-pyrrolidinone in binary mixtures

Journal of Solution Chemistry, 1990
Dielectric permittivities of 2-pyrrolidinone - acetone, -dimethyl sulfoxide,-2-propanol, -dichloromethane and -water systems were measured as a function of mole fraction over the whole composition range at 30 and 50°C. The excess dielectric permittivities are predominantly negative for all the mixtures and the excess molar polarizations are negative ...
P. Ruostesuo, P. Piril�-Honkanen
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Optimization of pyrrolidinone based HIV protease inhibitors

Bioorganic & Medicinal Chemistry Letters, 2005
Optimization of P1-substituted pyrrolidinone based HIV protease inhibitors has yielded analogs with very potent antiviral activity.
Ronald G, Sherrill, C Webster, Andrews, William J, Bock, Ronda G, Davis-Ward, Eric S, Furfine, Richard J, Hazen, Randy D, Rutkowske, Andrew, Spaltenstein, Lois L, Wright   +8 more
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1-Methyl-2-pyrrolidinone

2009
[872-50-4] C5H9NO (MW 99.15) InChI = 1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3 InChIKey = SECXISVLQFMRJM-UHFFFAOYSA-N (special solvent;1 source of enolates2) Alternate Names: NMP; N-methylpyrrolidone. Physical Data: mp −24.4 °C; bp 202 °C; d 1.030 g cm−3.
Peteris Trapencieris, Julie A. Pigza
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Hypolipidemic Activity of Substituted 2-Pyrrolidinones in Rodents

Journal of Pharmaceutical Sciences, 1983
A series of substituted 2-pyrrolidinones was evaluated for hypolipidemic activity at 20 and 30 mg/kg/day in CF1 male mice. 4-Phenyl-5,5-dicarbethoxy-2-pyrrolidinone was the most potent compound at 30 mg/kg/day, reducing serum triglyceride levels 52% after 14 days of dosing and serum cholesterol levels 48% after 16 days of dosing.
G H, Cocolas, J M, Chapman, P J, Voorstad, I H, Hall   +3 more
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Biotransformations in the Synthesis of 2‐Pyrrolidinones and 2‐Pyrrolinones

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
FELLUGA, FULVIA, V. GOMBAC, PITACCO, GIULIANA, VALENTIN, ENNIO   +3 more
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