Aryloxide-facilitated catalyst turnover in enantioselective α,β-unsaturated acyl ammonium catalysis [PDF]
, 2017 The authors thank the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013) ERC grant agreement no. 279850 (A.D.S) and the EPSRC (EP/J018139/1, A.M.) for funding. A.D.S.
Abbasov +39 more
core +10 more sources
Radical Cyclization of Trichloroacetamides: Synthesis of Lactams [PDF]
, 2018 Trichloroacetamides can act as radical precursors to synthesize nitrogen-containing heterocycles in a variety of processes, mainly involving atom transfer radical cyclizations (ATRC), mediated by Cu(I) or Ru(II) catalysts, and the hydride reductive ...
Bonjoch i Sesé, Josep +3 more
core +1 more source
Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin : polar myosin II inhibitors with superior research tool properties [PDF]
, 2017 In search of myosin II inhibitors with superior research tool properties, a chemical optimization campaign of the blebbistatin scaffold was conducted in this paper. (S)-Blebbistatin is the best known small-molecule inhibitor of myosin II ATPase activity.
Bracke, Marc +6 more
core +1 more source
Diversity-oriented synthesis of bicyclic fragments containing privileged azines [PDF]
, 2019 An innovative and efficient reagent- and scaffold-based diversity oriented synthesis (DOS) of a fragment set was developed for fragment-based drug discovery (FBDD) programs.
Luise, Nicola, Wyatt, Paul G.
core +2 more sources
Singlet oxygen-mediated one-pot chemoselective peptide–peptide ligation [PDF]
, 2017 We here describe a furan oxidation based site-specific chemical ligation approach using unprotected peptide segments. This approach involves two steps: after photooxidation of a furan-containing peptide, ligation is achieved by reaction of the unmasked ...
Antonatou, Eirini +2 more
core +2 more sources
Synthesis of green solvents from bio-based lactones using heterogeneous copper catalysts [PDF]
, 2023 In this paper, the synthesis of green solvents N-alkyl-pyrrolidinones starting from γ-valerolactone using non-noble, supported copper catalysts is proposed.
Begni, Federico +7 more
core +1 more source
Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling [PDF]
, 2013 Pramanicin (PMC) is an antifungal agent that was previously demonstrated to exhibit antiangiogenic and anticancer properties in a few in vitro studies. We initially screened a number of PMC analogs for their cytotoxic effects on HCT116 human colon cancer
Başağa, Hüveyda +5 more
core +1 more source
A steric tethering approach enables palladium-catalysed C-H activation of primary amino alcohols. [PDF]
, 2015 Aliphatic primary amines are a class of chemical feedstock essential to the synthesis of higher-order nitrogen-containing molecules, commonly found in biologically active compounds and pharmaceutical agents.
A McNally +52 more
core +3 more sources
An Efficient Protocol for the Palladium-Catalyzed Asymmetric Decarboxylative Allylic Alkylation Using Low Palladium Concentrations and a Palladium(II) Precatalyst [PDF]
, 2015 Enantioselective catalytic allylic alkylation for the synthesis of 2-alkyl-2-allylcycloalkanones and 3,3-disubstituted pyrrolidinones, piperidinones and piperazinones has been previously reported by our laboratory.
Craig, Robert A., II +6 more
core +1 more source
Catalytic asymmetric C-H insertion reactions of α-diazocarbonyl compounds [PDF]
, 2010 The purpose of this review is to provide an overview of the development of asymmetric catalysts for C-H insertion reactions over the past two decades, focusing on the application of these catalysts in the decomposition of α-diazocarbonyl compounds. Given
Ford, Alan +2 more
core +1 more source