Results 11 to 20 of about 2,138 (143)

Lewis Base‐Catalysed Enantioselective Radical Conjugate Addition for the Synthesis of Enantioenriched Pyrrolidinones [PDF]

, 2022
We report a catalytic asymmetric protocol for the preparation of chiral pyrrolidinones proceeding via a radical pathway. The chemistry exploits the combination of photoredox catalysis and Lewis base catalysis to realise the first example of asymmetric ...
Schiel, Florian, Ermini, Elena, Hartley, Will C., Melchiorre, Paolo, Will C. Hartley, Elena Ermini, Paolo Melchiorre, Florian Schiel   +7 more
core   +2 more sources

Synthesis of Functionalized Pyrrolidinone Scaffolds via Smiles-Truce Cascade. [PDF]

Org Lett, 2023
Arylsulfonamides have been found to react with cyclopropane diesters under simple base treatment to give α-arylated pyrrolidinones. This one-pot process comprises three steps: nucleophilic ring-opening of the cyclopropane, reaction of the resulting ...
Sephton T, Large JM, Butterworth S, Greaney MF.   +3 more
europepmc   +2 more sources

Diastereoselective synthesis of fused lactone-pyrrolidinones; application to a formal synthesis of (-)-salinosporamide A. [PDF]

, 2014
A mild, diastereoselective synthesis of fused lactone-pyrrolidinones using an oxidative radical cyclization is reported.
Vincenzo Garzya (1330896), Jonathan W. Burton (1330902), Amber L. Thompson, Simon J. Sprague, Léo B. Marx, Simon J. Sprague (1330890), Jonathan W. Burton, Angus W. J. Logan (1330893), Robert W. Foster (1330899), Amber L. Thompson (1307106), Angus W. J. Logan, Robert W. Foster, Michal S. Hallside, Michal S. Hallside (1330887), Léo B. Marx (1330884), Vincenzo Garzya   +15 more
core   +1 more source

Microwave-assisted synthesis of pyrrolidinone derivatives using 1,1’-butylenebis(3-sulfo-3H-imidazol-1-ium) chloride in ethylene glycol

Green Processing and Synthesis, 2019
The energy efficiency of the microwave-assisted synthesis of pyrrolidinones was demonstrated using catalytic loading of 1,1’-butylene-bis(3-sulfo-3H-imidazol-1-ium) chloride as a sulfonic acid functionalized ionic liquid in ethylene glycol as green ...
Khaligh Nader Ghaffari, Mihankhah Taraneh, Johan Mohd Rafie, Titinchi Salam J.J.   +3 more
doaj   +1 more source

A Flexible Approach to Protected (4S,5S)-5-Alkyl-1-benzyl-4-benzyloxy-2-pyrrolidinones

, 2011
[image omitted] We report in this paper a flexible approach to (4S,5S)-5-alkyl-1-benzyl-4-benzyloxy-2-pyrrolidinones 7 starting from the known 5-alkyl-1-benzyl-4-benzyloxy-5-hydroxy-2-pyrrolidinones 6.
Xiao, Zhen-Hua, Liang-Xian Liu, Pei-Qiang Huang, Huang, Pei-Qiang, 黄培强, Liu, Liang-Xian, Liu, Cong, Zhen-Hua Xiao, Cong Liu   +8 more
core   +1 more source

Synthesis of β‑Halo-pyrrolidinones through a Tandem Sequence of 5‑Endo Halolactamization and C–H Oxidative Functionalization

, 2016
A tandem sequence of 5-endo halolactamization and direct C–H oxidative functionalization is described. A range of β-halo-pyrrolidinones can be efficiently synthesized using this method, making it an excellent approach for constructing natural products ...
Liwei Liu (1475560), Yu Tang (343157), Xiaofan Liu (141518), Mingcan Lv (1702126), Hejing Feng (1702129)   +4 more
core   +1 more source

Iridium-Catalyzed Reductive Amination of Levulinic Acid to Pyrrolidinones under H-2 in Water

, 2017
The synthesis of pyrrolidinones from reductive amination of levulinic acid (LA) with primary amines is reported. Pyrrolidinones have various applications such as surfactants, pharmaceutical intermediates, dispersants, and solvents.
Xu, Zhanwei, Liu, Kairui, Zhang, Z. Conrad, Jiang, Hong, Yan, Peifang   +4 more
core   +1 more source

Unexpected reaction of b-cyclodextrin tosylate with pyrrolidinones

, 2006
Substitution reactions of 6I-O-p-tolylsulfonylcyclomaltoheptaose with alkyl- and arylamines in 1-methyl-2-pyrrolidinone and various pyrrolidinones were investigated.
SALVADORI, PIERO, RAFFAELLI A., UCCELLO BARRETTA, GLORIA, CUZZOLA A., BALZANO, FEDERICA, PANELLI L., Cuzzola Angela, Panelli Laura, Salvadori Piero, Balzano Federica, UccelloBarretta Gloria, Raffaelli Andrea   +11 more
core   +1 more source

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

Advanced Science, EarlyView.
TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang, Yuping Zhang, Xiaoning Su, Ning Liu, Hui Zeng, Bo Yang, Yang Xue, Fang Guo, Changkui Liu   +8 more
wiley   +1 more source

2-Pyrrolidinones and 3-Pyrrolin-2-ones: A Study on the Chemical Reactivity of These Structural Moieties [PDF]

, 2011
The chemical reactivity of 2-pyrrolidinones and 3-pyrrolin-2-ones was evaluated in reactions of addition, nucleophilic substitution, elimination, and reduction as well as the protection of the lactamic nitrogen.
José C. F. Alves
core   +1 more source