Results 41 to 50 of about 2,072 (186)
The pivotal role of β‐lactone stereochemistry in the development of SARS‐CoV‐2 Mpro inhibitors
Protein Science, Volume 35, Issue 7, July 2026.Abstract From the arrival of the SARS‐CoV‐2 coronavirus in 2019 and its associated COVID‐19 pandemic, worldwide efforts have been focused on developing a drug to treat patients. The SARS‐CoV‐2 main protease (Mpro) is one of the main targets for drug design due to its key role in the virus replication and its distinguished ability to cleave peptides ...
Katarzyna Świderek, Vicent Moliner
wiley +1 more source
Pyrrolidinones from the Ascomycete Fungus Albonectria rigidiuscula
, 2016 The new pyrrolidinones, rigidiusculamides A−D (1−4), have been isolated from the crude extract of the ascomycete fungus Albonectria rigidiuscula. The structures of these compounds were elucidated primarily by NMR experiments.
Shuchun Liu (2254618) +4 more
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Synthesis of the pyrrolidinone core of oxazolomycin A
, 2009 This thesis describes the development of synthetic strategies towards the densely functionalised pyrrolidinone core of the polyene β-lactone-γ-lactam antibiotic oxazolomycin A. Chapter 1 The oxazolomycins The oxazolomycins, a unique class of biologically active molecules containing a spiro-fused β-lactone-γ-lactam ring system are introduced.
openaire +2 more sources
ChemElectroChem, Volume 13, Issue 12, 17 June 2026.Sol‐gel synthesis is shown to produce Ni‐rich Li‐rich layered oxide cathodes with superior phase purity, crystallinity and reduced surface Li2CO3, yielding smaller homogeneous particles. These improvements translate into significantly enhanced electrochemical performance (~200 mAh g−1; 99.5% Coulombic efficiency; 80.6% capacity retention after 500 ...
Andrea Cioffi +3 more
wiley +1 more source
Towards Reaction Control: cis-Diastereoselective Reductive Dehydroxylation of 5-Alkyl-4-Benzyloxy-5-Hydroxy-2-Pyrrolidinones [PDF]
, 2012 通讯作者地址: Huang, PQA chemo-, regio-, and stereoselectively controlled reaction is highly desirable, yet challenging in organic synthesis. Diversely substituted cis and trans isomers of 2-alkyl-3-pyrrolidinols, 5-alkyl-4-hydroxy-2-pyrrolidinones, beta ...
叶剑良 +6 more
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Electroreductive Desulfurization of Thioacetals
ChemElectroChem, Volume 13, Issue 12, 17 June 2026.A metal‐free electrochemical protocol enabled desulfurization of thioacetals under ambient conditions. Aryl substituents on sulfur act as internal electroauxiliaries to promote C(sp3)─S bond cleavage via a radical pathway, effectively serving as alternative to the Mozingo reduction.
Ellymay Goossens +7 more
wiley +1 more source
A photoredox/copper-catalyzed cascade radical cyclization/phosphorothiolation reaction of N-allylbromoacetamides and P(O)SH compounds has been established. A broad range of novel nonfluorine- or difluoro-substituted 2-pyrrolidinones bearing the C(sp3)-SP(
Weilong Qu (11705098) +6 more
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, 2002 The inter- and intra-mol. regioselective cyclocarbonylative coupling of 2-aminophenol and 2-aminothiophenol with various allyl halides was achieved in the presence of a catalytic amt.
V. Sgobba +11 more
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European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer +6 more
wiley +1 more source
MnCl2‐Catalyzed Photochemical Functionalization of Unactivated C(sp3)H Bonds
ChemSusChem, Volume 19, Issue 11, 15 June 2026.A photochemical method enables the activation of alkanes, utilizing cheap and abundant MnCl2 as the photocatalyst. Alkenylation and alkylation reactions are performed, affording the desired products in good yields. Activation of inert C(sp3)H bonds is of great importance in organic synthesis, since it can functionalize unreactive molecules, such as ...
Naya A. Stini +3 more
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