Results 61 to 70 of about 2,072 (186)

Functionalised pyrrolidinones by conjugate addition of stabilised enolates and reformatsky reagents

, 1996
The α,β-unsaturated lactam 1b has been found to readily undergo conjugate addition reactions with a range of stabilised carbon nucleophiles and Reformatsky reagents under mild conditions in good yield with high diastereoselectivity.
Dyer, J, Keeling, S, Moloney, MG, Moloney, Mark   +3 more
core   +1 more source

SYNTHESIS OF 5-SUBSTITUTED-3,3-DIMETHYL-2-PYRROLIDINONES - QUAT CHIRAL AUXILIARIES

, 1994
The synthesis of a series of chiral auxiliaries, 5-substituted-3,3-dimethyl-2-pyrrolidinones, "quats", from L-glutamic acid is described. Efficient regeneration of the chiral auxiliaries from their N-pivaloyl derivatives is readily achieved with LiOH in ...
Gilles J.-M. Doisneau, Hitesh J. Sanganee, PRODGER, J, SANGANEE, H, Stephen G. Davies, DAVIES, S, Jeremy C. Prodger, DOISNEAU, G   +7 more
core   +1 more source

Simple and Efficient Synthesis of Substituted 2-Pyrrolidinones, 2-Pyrrolones, and Pyrrolidines from Enaminones of Baylis−Hillman Derivatives of 3-Isoxazolecarbaldehydes^§,‡

, 2016
The enaminones, generated from derivatives of appropriately substituted Baylis−Hillman adducts of 3-isoxazolecarbaldehydes, undergo intramolecular ring-closure reactions to afford substituted 2-pyrrolidinones, 1,5-dihydro-2-pyrrolones, and N-substituted ...
Rashmi Saxena (2696164), Sanjay Batra (1613422), Vijay Singh (1439023)   +2 more
core   +2 more sources

Stereoselective synthesis of enantiomerically pure 4,5-disubstituted pyrrolidinones from beta-amino esters

, 1999
alpha-Alkylation of N-tosyl-protected beta-amino esters with LDA as the base led to high anti selectivity for the newly formed C-C bond. The alpha-alkylated beta-amino esters were further transformed to enantiomerically pure 4,5-disubstituted ...
Albert S.C Chan, Wu, P, Wang, JB, Jianbo Wang, Yihua Hou, Peng Wu, Zhaohui Qu, Qu, ZH, Chan, ASC, Hou, YH   +9 more
core   +1 more source

Synthesis and absolute configuration of three isomeric spiro-bis(2-pyrrolidinones)

, 1982
Syntheses are described for three isomeric spiro-bis-(2-pyrrolidinones): 2,7-diazaspiro[4,4]nonane-3,8-dione (II), 2,7-diazaspiro[4.4]nonane-1,8-dione (IV) and 1,7-diazaspiro[4,4]nonane-2,8-dione (IV).
Zsuzsanna Majer, Klaus Kinski, Miklós Hollósi, Márton Kajtár   +3 more
core   +1 more source

A versatile approach to (4S,5R)-4-benzyloxy-5-(alpha-hydroxyalkyl)-2-pyrrolidinones: Experimental evidences to the computational predictions

, 2007
A versatile and highly diastereoselective four-step approach to (4S,5R)-N-benzyl-4-benzyloxy-5-(alpha-hydroxyalkyl)-2-pyrrolidinones 2, which starts from readily available (S)-N,O-dibenzylmalimide (5), is reported.
Zhang, Pan-Yuan, Jian-Liang Ye, Pei-Qiang Huang, Zhou, Xiang, Huang, Pei-Qiang, 黄培强, Xiang Zhou, Ye, Han-Liang, Pan-Yuan Zhang   +8 more
core   +1 more source

Selective Synthesis of 3‑Substituted Pyrrolidinones by Enol-Passerini and Anomalous Enol-Passerini Condensations

, 2018
Enols are used for the first time in a condensation with aldehydes and isocyanides to selectively give three- or pseudo-four-component adducts, depending on the reaction conditions. These new transformations have proven to be a convenient alternative for
Carlos F. Marcos (1580926), Ana G. Neo (2010589), Carlos F. Marcos, Ana G. Neo   +3 more
core   +1 more source

Complementary Stereocontrolled Approaches to 2-Pyrrolidinones Bearing a Vicinal Amino Diol Subunit with Three Continuous Chiral Centers:  A Formal Asymmetric Synthesis of (−)-Detoxinine

, 2016
We report herein two stereocomplementary approaches to erythro/trans and threo/cis vicinal amino diol subunits containing 2-pyrrolidinones (9 and 10) starting from the known enamides 7, easily available from malimides.
Jian-Liang Ye (1883158), Wen-Jun Liu (2436340), Pei-Qiang Huang (1643062), Xiang Zhou (164107)   +3 more
core   +2 more sources

Synthesis of Functionalized Pyrrolidinone Scaffolds via Smiles-Truce Cascade. [PDF]

Org Lett, 2023
Sephton T, Large JM, Butterworth S, Greaney MF.   +3 more
europepmc   +1 more source

Pyrrolidinones as Modulators of Neurogenesis [PDF]

ACS Medicinal Chemistry Letters, 2016
openaire   +2 more sources