Pyrrolidinones - Open Access .click

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Complementary Stereocontrolled Approaches to 2-Pyrrolidinones Bearing a Vicinal Amino Diol Subunit with Three Continuous Chiral Centers: A Formal Asymmetric Synthesis of (−)-Detoxinine

, 2016
We report herein two stereocomplementary approaches to erythro/trans and threo/cis vicinal amino diol subunits containing 2-pyrrolidinones (9 and 10) starting from the known enamides 7, easily available from malimides.
Jian-Liang Ye (1883158) +3 more
core +2 more sources

A versatile approach to (4S,5R)-4-benzyloxy-5-(alpha-hydroxyalkyl)-2-pyrrolidinones: Experimental evidences to the computational predictions

, 2007
A versatile and highly diastereoselective four-step approach to (4S,5R)-N-benzyl-4-benzyloxy-5-(alpha-hydroxyalkyl)-2-pyrrolidinones 2, which starts from readily available (S)-N,O-dibenzylmalimide (5), is reported.
Zhang, Pan-Yuan +8 more
core +1 more source

Regio- and diastereoselective synthesis of 5-trans-substituted and 5,5-disubstituted 2-pyrrolidinones derived from (S)-malic acid

, 2015
5-trans-Substituted 2-pyrrolidinones 6a, 6c and 6d and 5,5-disubstituted 2-pyrrolidinones 6e-k were regio- and diastereoselectively formed through the addition of organolithium species to imides 1a,b derived from malic acid, followed by addition of ...
Pilli, RA, Schuch, CM
core +1 more source

Controlled hydrolysis of aryltellurium trichlorides using 2-pyrrolidinones: Isolation and structural characterization of monomeric aryltellurium(IV) monohydroxides

, 2011
Controlled hydrolysis of aryltellurium trichlorides using 2-pyrrolidinones: Isolation and structural characterization of monomeric aryltellurium(IV ...
R Butcher (12222107) +4 more
core

N,N-(dimethylamino)-2-pyrrolidinones from the rearrangement of N-allyl-N ',N '-dimethyl-2,2-dichlorohydrazides promoted by CuCl-N,N,N ',N '-tetramethylethylendiamine

, 2000
Treatment of N-allyl-N¢,N¢-dimethyl-2,2-dichlorohydrazides with CuCl/TMEDA in ethyl acetate35is a mild and easy method for preparing N-(dimethylamino)-2-pyrrolidinones.
Parsons AF +3 more
core +1 more source

Halogen atom transfer radical cyclization of N-allyl-N-benzyl-2,2-dihaloamides to 2-pyrrolidinones, promoted by Fe-0-FeCl3 or CuCl-TMEDA

, 1997
The halogen atom transfer radical cyclization of a N-allyl-N-benzyl-2,2-dihaloamides to 2-pyrrolidinones has been carried out in high yields under mild conditions, in a reaction promoted by CuCl-TMEDA or Fe-0-FeCl3 in acetonitrile or N,N ...
Franco Ghelfi +9 more
core +1 more source

Selective Synthesis of 3‑Substituted Pyrrolidinones by Enol-Passerini and Anomalous Enol-Passerini Condensations

, 2018
Enols are used for the first time in a condensation with aldehydes and isocyanides to selectively give three- or pseudo-four-component adducts, depending on the reaction conditions. These new transformations have proven to be a convenient alternative for
Carlos F. Marcos (1580926) +3 more
core +1 more source

Synthesis of new optically active 2-pyrrolidinones.

, 2013
A new class of optically active 2-pyrrolidinones was synthesized, starting from S-pyroglutamic acid, a well known natural chiral synthon. The synthetic design followed led to the insertion of various substituents at positions 1 and 5 of the 2 ...
T. Mavromoustakos, P.M. Minakakis, E. Papavassilopoulou +2 more
core

Studies on the Asymmetric Synthesis of cis-5-Alkyl-4-hydroxy-2–pyrrolidinones and Studies on the New Method for Reduction of Amide [PDF]

, 2009
本论文包含以下各自独立的三方面内容：1，顺式-4-羟基-5-烷基-2-吡咯烷酮4的不对称合成研究；2，CytosporoneB类单羟基衍生物的合成；3，酰胺还原新方法研究。一、顺式-4-羟基-5-烷基-2-吡咯烷酮4的不对称合成研究：很多天然产物中含有顺式-4-羟基-5-烷基-2-吡咯烷酮亚结构，它们大多数具有很好的生理活性。此结构开环后得到的γ-氨基-β-羟基酸是一类特种氨基酸，它们是许多具有重要生理活性天然产物的结构单元。因此，关于此类化合物的研究一直吸引着人们的兴趣 ...
向少华
core

Synthesis and structural investigation of some 1,4-disubstituted-2-pyrrolidinones

ARKIVOC, 2005
Kristina Brokaite +2 more
doaj +1 more source