Results 51 to 60 of about 2,138 (143)
An alternative stereoselective synthesis of protected trans-5-alkyl-4-hydroxy-2-pyrrolidinones
, 2007 A flexible approach to protected trans-5-alkyl-4-hydroxy-2-pyrrolidinones was described. The key step involved the alpha-amidoalkylation of benzenesulfone derived from (S)-malic acid, with organozinc reagents generated in situ from Grignard reagents and ...
Chen, AQ +4 more
core +1 more source
Alkoxyallenes in Modern Synthesis: Reactivity, Catalysis, and Complexity Generation
Advanced Synthesis &Catalysis, Volume 368, Issue 17, 1 September 2026.The last decade has witnessed a remarkable transformation in alkoxyallene chemistry. Although historically employed as synthetic equivalents of acrolein or as versatile 3C synthons, alkoxyallenes are now increasingly recognized as highly adaptable platforms for synthetic design.
A. Lanfranco +5 more
wiley +1 more source
, 2002 The inter- and intra-mol. regioselective cyclocarbonylative coupling of 2-aminophenol and 2-aminothiophenol with various allyl halides was achieved in the presence of a catalytic amt.
V. Sgobba +11 more
core +1 more source
Functionalised pyrrolidinones by conjugate addition of stabilised enolates and reformatsky reagents
, 1996 The α,β-unsaturated lactam 1b has been found to readily undergo conjugate addition reactions with a range of stabilised carbon nucleophiles and Reformatsky reagents under mild conditions in good yield with high diastereoselectivity.
James Dyer +2 more
core +1 more source
SYNTHESIS OF 5-SUBSTITUTED-3,3-DIMETHYL-2-PYRROLIDINONES - QUAT CHIRAL AUXILIARIES
, 1994 The synthesis of a series of chiral auxiliaries, 5-substituted-3,3-dimethyl-2-pyrrolidinones, "quats", from L-glutamic acid is described. Efficient regeneration of the chiral auxiliaries from their N-pivaloyl derivatives is readily achieved with LiOH in ...
Gilles J.-M. Doisneau +3 more
core +1 more source
Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1.
, 2006 The synthesis and preliminary structure-activity relationship of a series of pyrrolidinones are described. These pyrrolidinones have been characterized as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) which are highly potent against wild-
Wolff, Karen +12 more
core
, 2016 Visible light promoted single electron reduction of bromocyclopropyl cyclization scaffolds enabled by photoredox catalysis initiates a novel tandem radical cyclization/sigmatropic rearrangement to generate tricyclic pyrrolidinones having considerable ...
Joseph W. Tucker (1489075) +1 more
core +1 more source
, 2019 This paper presents a novel and efficient protocol for the synthesis of pyrrolidinones using catalytic loading of 1,1'-butylenebis(3-sulfo-3H-imidazol-1-ium) hydrogen sulfate as a recyclable Brönsted acid ionic liquid through ball milling process at room
Taraneh Mihankhah (6422120) +2 more
core +1 more source
A photoredox/copper-catalyzed cascade radical cyclization/phosphorothiolation reaction of N-allylbromoacetamides and P(O)SH compounds has been established. A broad range of novel nonfluorine- or difluoro-substituted 2-pyrrolidinones bearing the C(sp3)-SP(
Weilong Qu (11705098) +6 more
core +1 more source
Synthesis and absolute configuration of three isomeric spiro-bis(2-pyrrolidinones)
, 1982 Syntheses are described for three isomeric spiro-bis-(2-pyrrolidinones): 2,7-diazaspiro[4,4]nonane-3,8-dione (II), 2,7-diazaspiro[4.4]nonane-1,8-dione (IV) and 1,7-diazaspiro[4,4]nonane-2,8-dione (IV).
Zsuzsanna Majer +3 more
core +1 more source