Results 121 to 130 of about 253,123 (156)

LC/MS study of the diversity and distribution of pyrrolizidine alkaloids in Crotalaria species growing in Colombia.

Journal of Separation Science, 2020
Hepatotoxic and genotoxic pyrrolizidine alkaloids have been involved in the acute poisoning of animals and humans. Crotalaria (Fabaceae) species contain these alkaloids.
Fausto Prada, E. Stashenko, J. Martínez
semanticscholar   +1 more source

Pulmonary toxicity is a common phenomenon of toxic pyrrolizidine alkaloids.

Journal of environmental science and health. Part C, Toxicology and carcinogenesis, 2020
The hepatotoxic pyrrolizidine alkaloids (PAs) are metabolically activated in the liver to form reactive dehydro-PAs, which generate pyrrole-protein adducts leading to hepatotoxicity.
Zijing Song, Yisheng He, Jiang Ma, P. Fu, G. Lin   +4 more
semanticscholar   +1 more source

Transfer of pyrrolizidine alkaloids between living plants: A disregarded source of contaminations.

Environmental Pollution, 2019
To elucidate the origin of the wide-spread contaminations of plant derived commodities with various alkaloids, we employed co-cultures of pyrrolizidine alkaloid (PA) containing Senecio jacobaea plants with various alkaloid free acceptor plants.
D. Selmar, Carina Wittke, Iris Beck-von Wolffersdorff, B. Klier, Laura Lewerenz, M. Kleinwächter, Melanie Nowak   +6 more
semanticscholar   +1 more source

Simultaneous determination of pesticides, mycotoxins, tropane alkaloids, growth regulators, and pyrrolizidine alkaloids in oats and whole wheat grains after online clean-up via two-dimensional liquid chromatography tandem mass spectrometry

Journal of Environmental Science and Health. Part B - Pesticides, Food Contaminants, and Agricultural Wastes, 2019
In this study, a two-dimensional liquid chromatography tandem mass spectrometry method was developed and validated for the determination of pesticide residues and contaminants in whole wheat grains and oats.
M. Urban, S. Hann, Helmut Rost
semanticscholar   +1 more source

Molecularly imprinted polymers-solid phase microextraction coupled with ultra-high performance liquid chromatography-tandem mass spectrometry for rapid analysis of pyrrolizidine alkaloids in herbal medicine.

Journal of Separation Science, 2019
Pyrrolizidine alkaloids are reported as the most widely distributed natural toxins and pyrrolizidine alkaloid-containing herbal medicines are probably the most common poisonous plants affecting humans.
Zhi-Min Luo, Guo-Ning Chen, Xuan Li, Lu Wang, Hua Shu, Xiang-Yang Cui, Chun-Ran Chang, Aiguo Zeng, Qiang Fu   +8 more
semanticscholar   +1 more source

Efficient Extraction of Pyrrolizidine Alkaloids from Plants by Pressurised Liquid Extraction – A Preliminary Study

Planta Medica, 2019
Pyrrolizidine alkaloids and their corresponding pyrrolizidine alkaloid-N-oxides are secondary plant constituents that became the subject of public concern due to their hepatotoxic, pneumotoxic, genotoxic, and cytotoxic effects.
T. Kopp, Liesa Salzer, Mona Abdel-Tawab, B. Mizaikoff   +3 more
semanticscholar   +1 more source

Pyrrolizidine alkaloids of Blue Heliotrope (Heliotropium amplexicaule) and their presence in Australian honey.

Journal of Agricultural and Food Chemistry, 2019
Blue heliotrope (Heliotropium amplexicaule) is an invasive environmental weed that is widely naturalised in eastern Australia and has been implicated as a source of pyrrolizidine alkaloid (PA) poisoning in livestock.
Matheus Carpinelli de Jesus, N. L. Hungerford, S. Carter, S. Anuj, J. Blanchfield, J. D. De Voss, M. Fletcher   +6 more
semanticscholar   +1 more source

Metabolism-mediated cytotoxicity and genotoxicity of pyrrolizidine alkaloids

Archives of Toxicology, 2021
Yisheng He, Lin Zhu, Jiang Ma, G. Lin
semanticscholar   +1 more source

Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells.

Food and Chemical Toxicology, 2018
Plant-based 1,2-unsaturated Pyrrolizidine Alkaloids (PAs) can be found as contaminants in foods like teas, herbs and honey. PAs are responsible for liver genotoxicity/carcinogenicity following metabolic activation, making them a relevant concern for ...
Ashley Allemang, C. Mahony, C. Lester, S. Pfuhler   +3 more
semanticscholar   +1 more source

Determination and regulation of hepatotoxic pyrrolizidine alkaloids in food: A critical review of recent research.

Food and Chemical Toxicology, 2018
Pyrrolizidine alkaloids (PAs) are secondary metabolites of plants. PAs have been reported to be hepatotoxic, mutagenic, and carcinogenic; they are a significant group of natural toxins affecting livestock, wildlife, and humans.
Chuanhui Ma, Yang Liu, Lin Zhu, Hong Ji, Xun Song, Hui Guo, T. Yi   +6 more
semanticscholar   +1 more source