Results 141 to 150 of about 79,429 (193)
Transjugular intrahepatic portosystemic shunt for the treatment of hepatic sinusoidal obstruction syndrome caused by pyrrolizidine alkaloids: A multicenter retrospective study. [PDF]
HeliyonWang C +7 more
europepmc +1 more source
In vitro-in silico study on the influence of dose, fraction bioactivated and endpoint used on the relative potency value of pyrrolizidine alkaloid N-oxides compared to parent pyrrolizidine alkaloids. [PDF]
Curr Res ToxicolAlhejji Y +5 more
europepmc +1 more source
Genotoxic Pyrrolizidine Alkaloids — Mechanisms Leading to DNA Adduct Formation and Tumorigenicity
International Journal of Molecular Sciences, 2002 Plants that contain pyrrolizidine alkaloids are widely distributed in the world. Although pyrrolizidine alkaloids have been shown to be genotoxic and tumorigenic in experimental animals, the mechanisms of actions have not been fully understood.
Ge Lin, Peter P Fu, Qingsu Xia
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2018
Naturally occurring pyrrolizidine alkaloids (PAs) are isolated from plants and other sources. The interest of the scientific community in these compounds owes itself to their high toxicity and biological activity, as well as to the challenge of synthesizing their pyrrolizidine scaffold.
Joaquín, Tamariz +3 more
openaire +3 more sources
Naturally occurring pyrrolizidine alkaloids (PAs) are isolated from plants and other sources. The interest of the scientific community in these compounds owes itself to their high toxicity and biological activity, as well as to the challenge of synthesizing their pyrrolizidine scaffold.
Joaquín, Tamariz +3 more
openaire +3 more sources
Pyrrolizidine Alkaloids From Echium glomeratum (Boraginaceae) [PDF]
Phytochemistry, 2008 The methanolic extract of the whole plant of Echium glomeratum Poir. (Boraginaceae) has afforded five pyrrolizidine alkaloids, three that were (7S, 8R)-petranine (1), (7S, 8S)-petranine (2), and (7R, 8R)-petranine (3a) or (7R, 8S)-petranine (3b ...
Feras Q. Alali +2 more
exaly +1 more source
Toxicity of Pyrrolizidine Alkaloids
Nature, 1968A new class of metabolite, with a pyrrole-like structure, has been demonstrated in the tissues of animals poisoned by pyrrolizidine alkaloids. There is some correlation between the degree of hepato-toxicity and the amount of “pyrrole” found in the liver.
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1982
Previous chapters in this series by Warren appeared in 1955 (310) and 1966 (311). Since then an authoritative book by Bull, Culvenor, and Dick, on the chemistry and pharmacology of pyrrolizidine alkaloids has been published (60). Comprehensive reviews on the alkaloids (312), their chemotaxonomic significance (77), and general pyrrolizidine chemistry ...
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Previous chapters in this series by Warren appeared in 1955 (310) and 1966 (311). Since then an authoritative book by Bull, Culvenor, and Dick, on the chemistry and pharmacology of pyrrolizidine alkaloids has been published (60). Comprehensive reviews on the alkaloids (312), their chemotaxonomic significance (77), and general pyrrolizidine chemistry ...
openaire +2 more sources
The Pyrrolizidine Alkaloids. II
1966Ten years have elapsed since the pyrrolizidine alkaloids were reviewed in this series (387), and it is a not much shorter period since they formed the subject of an excellent account by Leonard (329) and a masterly summary by Boit (225). The intervening years have seen considerable activity in the isolation of new alkaloids, the determination of ...
openaire +2 more sources