Foods, 2020 Recent and unexpected food alerts about relatively high amounts of pyrrolizidine alkaloids in oregano samples have stressed the need to develop analytical strategies to ensure food safety in this type of foodstuff.
Sergio Izcara +3 more
doaj +2 more sources
Statement on the risks for human health related to the presence of pyrrolizidine alkaloids in honey, tea, herbal infusions and food supplements [PDF]
EFSA journal. European Food Safety Authority, 2017 EFSA was asked by the European Commission to deliver a scientific opinion on the risks for human health related to the presence of pyrrolizidine alkaloids (PAs) in honey, tea, herbal infusions and food supplements and to identify the PAs of relevance in ...
core +2 more sources
Pyrrolizidine Alkaloids: Biosynthesis, Biological Activities and Occurrence in Crop Plants
Molecules, 2019 Pyrrolizidine alkaloids (PAs) are heterocyclic secondary metabolites with a typical pyrrolizidine motif predominantly produced by plants as defense chemicals against herbivores.
Sebastian Schramm +2 more
doaj +2 more sources
Pyrrolizidine alkaloids: An update on their metabolism and hepatotoxicity mechanism
Liver Research, 2019 Pyrrolizidine alkaloids (PAs) are among the most hepatotoxic natural compounds that are widely distributed throughout the world. Most PAs are metabolically activated to trigger toxicity.
Jie Xu +5 more
doaj +2 more sources
Hepatotoxicity of Pyrrolizidine Alkaloid Compound Intermedine: Comparison with Other Pyrrolizidine Alkaloids and Its Toxicological Mechanism. [PDF]
Toxins (Basel), 2021 Pyrrolizidine alkaloids (PAs) are common secondary plant compounds with hepatotoxicity. The consumption of herbal medicines and herbal teas containing PAs is one of the main causes of hepatic sinusoidal obstruction syndrome (HSOS), a potentially life ...
Wang Z +6 more
europepmc +2 more sources
Roots of Indian heliotrope (Heliotropium indicum) produce simple pyrrolizidine alkaloids using the same homospermidine oxidase involved in biosynthesis of complex pyrrolizidine alkaloids in aerial parts. [PDF]
Plant Biol (Stuttg)Indian heliotrope uses the same oxidase to produce complex pyrrolizidine alkaloid esters in aerial parts and simple pyrrolizidine alkaloids in roots. Abstract Pyrrolizidine alkaloids (PAs) are toxic specialized metabolites found in several plant lineages with independent evolutionary origins.
Zakaria MM, Salewski MB, Ober D.
europepmc +2 more sources
Molecules, 2021 Pyrrolizidine alkaloids (PAs) are a widespread group of secondary metabolites in plants. PAs are notorious for their acute hepatotoxicity, genotoxicity and neurological damage to humans and animals.
Xianqin Wei, W. Ruan, K. Vrieling
semanticscholar +1 more source
Molecules, 2021 Comfrey (Symphytum officinale) is a medicinal plant with anti-inflammatory, analgesic, and proliferative properties. However, its pharmaceutical application is hampered by the co-occurrence of toxic pyrrolizidine alkaloids (PAs) in its tissues.
M. M. Zakaria +2 more
semanticscholar +1 more source
Alcalóides pirrolizidínicos em espécies do gênero Senecio
Química Nova, 2006 Senecio species contain a large variety of secondary metabolites and many of these plants afford pyrrolizidine alkaloids. This paper is a review of the literature, describing 62 pyrrolizidine alkaloids already isolated in 62 of more than 2000 species of ...
Chana de Medeiros da Silva +2 more
doaj +3 more sources
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source