Results 11 to 20 of about 253,123 (156)

Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review

Molecules, 2021
Pyrrolizidine alkaloids (PAs) are a widespread group of secondary metabolites in plants. PAs are notorious for their acute hepatotoxicity, genotoxicity and neurological damage to humans and animals.
Xianqin Wei, Wei-Bin Ruan, K. Vrieling
semanticscholar   +1 more source

Hepatotoxicity of Pyrrolizidine Alkaloid Compound Intermedine: Comparison with Other Pyrrolizidine Alkaloids and Its Toxicological Mechanism

Toxins, 2021
Pyrrolizidine alkaloids (PAs) are common secondary plant compounds with hepatotoxicity. The consumption of herbal medicines and herbal teas containing PAs is one of the main causes of hepatic sinusoidal obstruction syndrome (HSOS), a potentially life ...
Zi-Qi Wang, Haolei Han, Chen Wang, Qin-Qin Zheng, Hongping Chen, Xiangchun Zhang, Ruyan Hou   +6 more
semanticscholar   +1 more source

Effective Solid Phase Extraction of Toxic Pyrrolizidine Alkaloids from Honey with Reusable Organosilyl-Sulfonated Halloysite Nanotubes

Separations, 2022
Pyrrolizidine alkaloids are plant secondary metabolites that have recently attracted attention as toxic contaminants in various foods and feeds as they are often harvested by accident.
Tobias Schlappack, Nina Weidacher, Christian W. Huck, Günther K. Bonn, Matthias Rainer   +4 more
doaj   +1 more source

First record of pyrrolizidine alkaloids in the southern African biotype of Chromolaena odorata (Asteraceae)

South African Journal of Botany, 2021
Pyrrolizidine alkaloids (PAs) are amino alcohols, often esterified with mono- or dicarboxylic acids, found in several plant families, including the Asteraceae. Pyrrolizidine alkaloids are used for plant defence against generalist invertebrate herbivores.
N. Dube, F. V. van Heerden, C. Zachariades, O. Uyi, T. Munyai   +4 more
semanticscholar   +1 more source

Comment on Pyrrolizidine Alkaloids and Terpenes from Senecio (Asteraceae): Chemistry and Research Gaps in Africa

Molecules, 2022
The genus Senecio is one of the largest in Asteraceae. There are thousands of species across the globe, either confirmed or awaiting taxonomic delimitation.
Nicholas John Sadgrove
doaj   +1 more source

Alcalóides pirrolizidínicos em espécies do gênero Senecio

Química Nova, 2006
Senecio species contain a large variety of secondary metabolites and many of these plants afford pyrrolizidine alkaloids. This paper is a review of the literature, describing 62 pyrrolizidine alkaloids already isolated in 62 of more than 2000 species of ...
Chana de Medeiros da Silva, Aline Abati Bolzan, Berta Maria Heinzmann   +2 more
doaj   +3 more sources

Assessment of Toxic Pyrrolizidine and Tropane Alkaloids in Herbal Teas and Culinary Herbs Using LC-Q-ToF/MS

Foods, 2023
Pyrrolizidine alkaloids are secondary metabolites produced by plants as a defense against insects. These can cause acute or chronic toxicity in humans. Therefore, avoiding potential poisoning from the consumption of tea and culinary plants contaminated ...
Zinar Pinar Gumus
doaj   +1 more source

Pyrrolizidine alkaloids in food and phytomedicine: Occurrence, exposure, toxicity, mechanisms, and risk assessment - A review.

Food and Chemical Toxicology, 2020
Among naturally occurring plant constituents, the 1,2-unsaturated pyrrolizidine alkaloids (in the following termed 'PAs') play a distinct role because of the large number of congeners occurring in nature and the pronounced toxicity of some congeners ...
D. Schrenk, Lan Gao, G. Lin, C. Mahony, P. Mulder, A. Peijnenburg, S. Pfuhler, I. Rietjens, L. Rutz, B. Steinhoff, A. These   +10 more
semanticscholar   +1 more source

Soil-borne microorganisms and soil-type affect pyrrolizidine alkaloids in Jacobaea vulgaris [PDF]

, 2009
Secondary metabolites like pyrrolizidine alkaloids (PAs) play a crucial part in plant defense. We studied the effects of soil-borne microorganisms and soil-type on pyrrolizidine alkaloids in roots and shoots of Jacobaea vulgaris.
Veen, J.A., van, Klinkhamer, P.G.L., Joosten, L., Mulder, P.P.J.   +3 more
core   +1 more source

Simultaneous determination of pyrrolizidine and tropane alkaloids in honey by liquid chromatography–mass spectrometry

Journal of Veterinary Research, 2022
Pyrrolizidine alkaloids (PAs) and tropane alkaloids (TAs) are natural contaminants of honey and respectively hepatoxic and neurotoxic compounds. Because honey is a popular constituent of the human diet, it is relevant to warrant the safety of the product.
Kowalczyk Ewelina, Kwiatek Krzysztof
doaj   +1 more source