Results 181 to 190 of about 141,799 (322)

Pyruvate carboxylase in lactating rat and rabbit mammary gland [PDF]

, 1969
Bilquis Gul, R. Dils
openalex   +1 more source

mTORC1‐USP30‐LEF1 Cascade Regulates Cancer Stemness and Malignant Progression Through Mitonuclear Crosstalk

MedComm, Volume 6, Issue 12, December 2025.
Nutrient deprivation triggers USP30 nuclear translocation via an N‐terminal nuclear localization signal (NLS), mediated through suppression of mTORC1‐dependent phosphorylation at serine 104, a modification constraining nuclear entry. Nuclear USP30 deubiquitinates TCF/LEF1 at K379 and K382 residues, disrupting recruitment of CBP/P300 co‐activators to ...
Xiaolin Li, Haowei Zhang, Jia Li, Cheng Luo, Zijian Yang, Jin Cai, Li Xia, Yapei Jiang, Ruonan Wang, Hongli Zeng, Yuetong Li, Haitao Yang, Tong Gao, Weidong Xie, Yaou Zhang, Naihan Xu   +15 more
wiley   +1 more source

Inhibiting glioblastoma stem cells by targeting pyruvate carboxylase: A novel therapeutic strategy with both opportunities and challenges. [PDF]

Neuro Oncol
Renoult O, Laurent-Blond M, Pecqueur C.
europepmc   +2 more sources

Lymphoblasts and diagnosis of pyruvate carboxylase deficiency.

, 1982
Goro Takada, Masatoshi Ohtake, Shigeaki Miyabayashi, Keiya Tada   +3 more
openalex   +2 more sources

Alcohol‐Related Liver Disease and Metabolic Dysfunction‐Associated Steatotic Liver Disease: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
Alcohol‐related (ALD) and metabolic dysfunction‐associated (MASLD) steatotic liver disease, while initiated by distinct etiologies (ethanol vs. metabolic stress), converge on shared core pathogenic pathways that drive progression. These include dysregulated lipid metabolism, programmed cell death, cellular senescence, gut dysbiosis, and immune ...
Yupin Tan, Yirui Hu, Ye Yang, Huikuan Chu   +3 more
wiley   +1 more source

The Pyruvate Carboxylase of Aspergillus niger

Journal of Biological Chemistry, 1962
S J, BLOOM, M J, JOHNSON
openaire   +2 more sources

Protein O‐GlcNAcylation in Health and Diseases

MedComm, Volume 6, Issue 12, December 2025.
We first introduced the beneficial effects of normal protein O‐GlcNAcylation on health, impacting biological processes such as gene expression, cell cycle progression, metabolism, and signal transduction. Next, we described the role of abnormal protein O‐GlcNAcylation in the development and progression of diseases, including neurodegenerative diseases,
Zhihong Ran, Chuanbao Chen, Jingfeng Ou, Guanyi Wu, Chao Yang, Xiaoyou Liu   +5 more
wiley   +1 more source

A Unique Case of Pyruvate Carboxylase Deficiency. [PDF]

Cureus, 2021
Hidalgo J, Campoverde L, Ortiz JF, Ruxmohan S, Eissa-Garcés A.   +4 more
europepmc   +1 more source

Subcellular Distribution of Pyruvate Carboxylase, Diphosphopyridine Nucleotide and Triphosphopyridine Nucleotide Isocitrate Dehydrogenases, and Malate Enzyme in Rat Brain

, 1968
Leon Salganicoff, Roger E. Koeppe
openalex   +1 more source

Multi‐omic data integration and exploiting metabolic models using systems biology approach increase precision in subtyping and early diagnosis of cancer

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cancer is a complex and heterogeneous disease characterized by various genetic and epigenetic alterations. Early diagnosis, accurate subtyping, and staging are essential for effective, personalized treatment and improved survival rates. Traditional diagnostic methods, such as biopsies, are invasive and carry operational risks that hinder ...
Ezgi Tanıl, Emrah Nikerel
wiley   +1 more source