Heliyon, 2022 Aims: Pyruvate dehydrogenase (PDH) catalyzes the decarboxylation of pyruvate to acetyl-CoA, which plays a key role in linking cytosolic glycolysis to mitochondria metabolism.
Yuko Katayama +2 more
exaly +3 more sources
Cell Reports, 2021 Summary: The pyruvate dehydrogenase complex (PDHc) is a giant enzymatic assembly involved in pyruvate oxidation. PDHc components have been characterized in isolation, but the complex’s quaternary structure has remained elusive due to sheer size ...
Fotis L Kyrilis +2 more
exaly +3 more sources
Case Report: A novel hemizygous missense PDHA1 variant in a Vietnamese boy with pyruvate dehydrogenase E1-alpha deficiency [PDF]
Frontiers in PediatricsA pyruvate dehydrogenase complex deficiency causes a reduction in adenosine triphosphate production and energy insufficiency, leading to neurological disorders.
Thi Thanh Ngan Nguyen +13 more
doaj +2 more sources
Rapid inhibition of pyruvate dehydrogenase: an initiating event in high dietary fat-induced loss of metabolic flexibility in the heart. [PDF]
PLoS ONE, 2013 Cardiac function depends on the ability to switch between fatty acid and glucose oxidation for energy production in response to changes in substrate availability and energetic stress.
Clair Crewe +2 more
doaj +1 more source
Binding of pyruvate dehydrogenase to the core of the human pyruvate dehydrogenase complex [PDF]
FEBS Letters, 2008 In human (h) pyruvate dehydrogenase complex (PDC) the pyruvate dehydrogenase (E1) is bound to the E1‐binding domain of dihydrolipoamide acetyltransferase (E2). The C‐terminal surface of the E1β subunit was scanned for the negatively charged residues involved in binding with E2.
Korotchkina, Lioubov G. +1 more
openaire +2 more sources
The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity [PDF]
Diabetes & Metabolism Journal, 2014 The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and ...
In-Kyu Lee
doaj +1 more source
Pyruvate dehydrogenase kinase activity of pig heart pyruvate dehydrogenase (E1 component of pyruvate dehydrogenase complex) [PDF]
Biochemical Journal, 1985 The pyruvate dehydrogenase (E1) and acetyltransferase (E2) components of pig heart and ox kidney pyruvate dehydrogenase (PDH) complex were separated and purified. The E1 component was phosphorylated (alpha-chain) and inactivated by MgATP. Phosphorylation was mainly confined to site 1.
A L, Kerbey, P J, Randle
openaire +2 more sources
Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism [PDF]
Diabetes & Metabolism Journal, 2018 Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex
Sungmi Park +6 more
doaj +1 more source
The relationships between transketolase, yeast pyruvate decarboxylase and pyruvate dehydrogenase of the pyruvate dehydrogenase complex [PDF]
FEBS Letters, 1993 The amino acid sequences of four thiamine pyrophosphate‐requiring enzymes were aligned with the published amino acid sequence of the transketolase of Hansenula polymorpha. Sequences of the combined α and β subunits of the E1 enzyme of the pyruvate dehydrogenase complexes of Homo sapiens and Bacillus stearothermophilus aligned well with the ...
Robinson, Brian H., Chun, Kathy
openaire +2 more sources
RNA Biology, 2023 The tricarboxylic acid (TCA) cycle is a central route for generating cellular energy and precursors for biosynthetic pathways. Emerging evidences have shown that the aberrations of metabolic enzymes which affect the integrity of TCA cycle are implicated ...
Tao Shen +4 more
doaj +1 more source