Results 21 to 30 of about 124,495 (263)

The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells

Cells, 2021
Pyruvate occupies a central metabolic node by virtue of its position at the crossroads of glycolysis and the tricarboxylic acid (TCA) cycle and its production and fate being governed by numerous cell-intrinsic and extrinsic factors.
Edward V. Prochownik, Huabo Wang
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Multi-omics Profiling Reveals the Effects of Exogenous Leucine on Carbohydrate and Energy Metabolism in Broccoli [PDF]

Shipin Kexue
To investigate the effects and molecular basis of leucine on carbohydrate and energy homeostasis in postharvest broccoli, an integrated transcriptomic and metabolomic analysis was conducted on postharvest broccoli treated with leucine soaking.
WANG Yunqiao, ZHANG Yuxiao, GAI Yingchao, WANG Huihui, ZOU Yongkang, Abbas AQLEEM, GUO Yanyin
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The Reaction of Pyruvate with Saccharopine Dehydrogenase [PDF]

European Journal of Biochemistry, 1978
The preceding paper in this journal has reported that pyruvate could be substituted for 2‐oxoglutarate as a substrate of saccharopine dehydrogenase [ɛ‐N‐(l‐glutaryl‐2)‐l‐lysine: NAD oxidoreductase (l‐lysine‐forming)] in the direction of reductive condensation.
K, Sugimoto, M, Fujioka
openaire   +2 more sources

Bortezomib-induced aerobic glycolysis contributes to chemotherapy-induced painful peripheral neuropathy

Molecular Pain, 2019
Chemotherapy-induced painful peripheral neuropathy (CIPN) is the most common toxicity associated with widely used chemotherapeutics. CIPN is the major cause of dose reduction or discontinuation of otherwise life-saving treatment.
Taylor Ludman, Ohannes K. Melemedjian
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Characterization of the metabolic shift between oxidative and fermentative growth in Saccharomyces cerevisiae by comparative ¹³C flux analysis

Microbial Cell Factories, 2005
Background One of the most fascinating properties of the biotechnologically important organism Saccharomyces cerevisiae is its ability to perform simultaneous respiration and fermentation at high growth rate even under fully aerobic conditions.
Wittmann Christoph, Frick Oliver
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A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency

JIMD Reports, 2019
Congenital lactic acidosis due to pyruvate dehydrogenase phosphatase (PDP) deficiency is very rare. PDP regulates pyruvate dehydrogenase complex (PDC) and defective PDP leads to PDC deficiency.
Jirair K. Bedoyan, Leah Hecht, Shulin Zhang, Stacey Tarrant, Ann Bergin, Didem Demirbas, Edward Yang, Ha Kyung Shin, George J. Grahame, Suzanne D. DeBrosse, Charles L. Hoppel, Douglas S. Kerr, Gerard T. Berry   +12 more
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Melatonin Therapy Modulates Cerebral Metabolism and Enhances Remyelination by Increasing PDK4 in a Mouse Model of Multiple Sclerosis

Frontiers in Pharmacology, 2019
Metabolic disturbances have been implicated in demyelinating diseases including multiple sclerosis (MS). Melatonin, a naturally occurring hormone, has emerged as a potent neuroprotective candidate to reduce myelin loss and improve MS outcomes.
Majid Ghareghani, Majid Ghareghani, Linda Scavo, Linda Scavo, Yahya Jand, Naser Farhadi, Hossein Sadeghi, Amir Ghanbari, Stefania Mondello, Stefania Mondello, Damien Arnoult, Sajjad Gharaghani, Kazem Zibara, Kazem Zibara   +13 more
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Extreme anoxia tolerance in crucian carp and goldfish through neofunctionalization of duplicated genes creating a new ethanol-producing pyruvate decarboxylase pathway

Scientific Reports, 2017
Without oxygen, most vertebrates die within minutes as they cannot meet cellular energy demands with anaerobic metabolism. However, fish of the genus Carassius (crucian carp and goldfish) have evolved a specialized metabolic system that allows them to ...
Cathrine E. Fagernes, Kåre-Olav Stensløkken, Åsmund K. Røhr, Michael Berenbrink, Stian Ellefsen, Göran E. Nilsson   +5 more
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Theoretical Analysis of the Built-in Metabolic Pathway Effect on the Metabolism of Erythrocyte-Bioreactors That Neutralize Ammonium

Metabolites, 2021
The limitations of the efficiency of ammonium-neutralizing erythrocyte-bioreactors based on glutamate dehydrogenase and alanine aminotransferase reactions were analyzed using a mathematical model.
Evgeniy Protasov, Larisa Koleva, Elizaveta Bovt, Fazoil I. Ataullakhanov, Elena Sinauridze   +4 more
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Pyruvate Dehydrogenase and Pyruvate Dehydrogenase Kinase Expression in Non Small Cell Lung Cancer and Tumor-Associated Stroma

Neoplasia: An International Journal for Oncology Research, 2005
Pyruvate dehydrogenase (PDH) catalyzes the conversion of pyruvate to acetyl-coenzyme A, which enters into the Krebs cycle, providing adenosine triphosphate (ATP) to the cell.
Michael I. Koukourakis, Alexandra Giatromanolaki, Efthimios Sivridis, Kevin C. Gatter, Adrian L. Harris   +4 more
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