Results 141 to 150 of about 125,120 (264)

Proteomic and Metabolomic Profiling Reveal Mitochondrial Transplantation–Mediated Reprogramming in Gastric Cancer Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Mitochondria provide multiple functions for cellular physiology. Transplantation of mitochondria isolated from gastric epithelial cells GES‐1 reducing the malignancy of gastric cancer cells AGS was previously reported. To elucidate the underlying mechanisms, TMT‐based proteomic analysis coupling ingenuity pathway software prediction revealed ...
Ping‐Chen Chen, Chen‐Kai Liu, Ching‐Chung Tsai, Erna Sulistyowati, Fu‐An Li, Chung‐Jung Liu, Deng‐Chyang Wu, Shih‐Hsuan Chou, Fu‐Chen Kuo, Bin Huang   +9 more
wiley   +1 more source

Pharmacological Inhibition of Pyruvate Dehydrogenase Kinase 4 Enhances Insulin Sensitivity in Mouse Models of Diabetes and Obesity. [PDF]

J Obes Metab Syndr
Kim MJ, Ha B, Kim RR, Lee JY, Lim CW, Ahn JH, Lee IK, Jeon JH.   +7 more
europepmc   +1 more source

Pyruvate dehydrogenase deficiency. [PDF]

Journal of Medical Genetics, 1994
G K, Brown, L J, Otero, M, LeGris, R M, Brown   +3 more
openaire   +2 more sources

Overgrazing‐Induced Root Carbohydrate Depletion During Winter Dormancy Drives the Decline of Stipa purpurea Populations in the Tibetan Alpine Steppe

Land Degradation &Development, EarlyView.
ABSTRACT Plant carbon allocation and physiology are influenced by overgrazing during the growth period. However, the response of plant physiological processes to overgrazing during winter dormancy remains unclear. We analyzed root physiological processes of Stipa purpurea in winter dormancy across three plots: over grazing (FG), exclusions of 2 years ...
Jianbo Wu, Qingquan Han, Sheng Zhang, Xiaodan Wang   +3 more
wiley   +1 more source

Exometabolomics Reveals Metabolic Modulation Induced by Chia Oil Supplementation in Adipose Tissue Explants From Obese Mice

Lipids, EarlyView.
The experimental design and the exometabolomic findings obtained by 1H‐NMR analysis of conditioned media from subcutaneous (SAT) and epididymal adipose tissue (EAT) explants of control and obese mice supplemented with chia oil (1.5% (w/w)). Following 8 weeks of control or high‐fat diet and 5 weeks of chia oil supplementation, SAT and EAT explants were ...
Gilson Costa dos Santos Jr, Agatha Assis‐Ferreira, Gabrielly Muniz‐Cassuce, Tatiana El Bacha, Christina Barja‐Fidalgo, Simone Vargas da Silva   +5 more
wiley   +1 more source

Phosphorylation of Pyruvate Dehydrogenase as a Marker of Neuronal Inactivity in the Enteric Nervous System. [PDF]

Neurogastroenterol Motil
Wemelle E, McClain JL, Gulbransen BD.
europepmc   +1 more source

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider, Divyani Garg, Vassilena Iankova, Thomas Klopstock   +3 more
wiley   +1 more source

Decreased Glucose Metabolism and Declined Chaperones Are Unique Features Required for the Survival of Senescent Fibroblasts and Pyruvate Dehydrogenase Is a Potent Senolytic Target. [PDF]

Aging Cell
Zhang M, Hu Z, Piao S, Song Y, Jia Y, Liu J, Zhao N, Liu A, Fu S, Sun W, Xu H, Yang Y, Gygi SP, Zhou C.   +13 more
europepmc   +1 more source

Wernicke's Encephalopathy Following Semaglutide Treatment for Obesity: A Systematic PRISMA Review of Case‐Based Evidence

Obesity, EarlyView.
ABSTRACT Objective Glucagon‐like peptide‐1 receptor agonists are increasingly prescribed for obesity. Although generally considered safe, marked appetite suppression and persistent gastrointestinal adverse effects may increase the risk of nutritional deficiencies.
Janice Bidesie, Erik Oudman
wiley   +1 more source

The role of pyruvate dehydrogenase in the lifespan determination of daphnids. [PDF]

Nat Commun
Chen W, Xu X, Zeng Z, Zhou M, Chen J, Hu G, Shen A, Li D, Xiangjiang L.   +8 more
europepmc   +1 more source