Results 1 to 10 of about 3,990 (75)

Mitochondrial proteins contribute to the pathogenesis of myasthenia gravis [PDF]

Scientific Reports
Myasthenia gravis (MG) is an autoimmune disorder mediated by B-cells, characterized by muscle weakness and fatigue. Mitochondria, essential for energy production and muscle function, have been implicated in MG.
Fangzheng Cao, Houwen Zhang, Bin Xu, Juan Wang, Bin Wu, Yu Zhou, Jialin Yu, Chunrong Li   +7 more
doaj   +2 more sources

The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4 [PDF]

Diabetes & Metabolism Journal, 2023
Sarcopenia, defined as a progressive loss of muscle mass and function, is typified by mitochondrial dysfunction and loss of mitochondrial resilience. Sarcopenia is associated not only with aging, but also with various metabolic diseases characterized by ...
Min-Ji Kim, Ibotombi Singh Sinam, Zerwa Siddique, Jae-Han Jeon, In-Kyu Lee   +4 more
doaj   +1 more source

Effects of Acute Hypoxic Stress on Physiological and Hepatic Metabolic Responses of Triploid Rainbow Trout (Oncorhynchus mykiss)

Frontiers in Physiology, 2022
This experiment simulated the hypoxic environment caused by actual production operations in fish farming (i.e., catching, gathering, transferring, and weighting) to study the effects of acute hypoxic conditions on the physiological and metabolic ...
Buying Han, Buying Han, Yuqiong Meng, Haining Tian, Changzhong Li, Yaopeng Li, Caidan Gongbao, Wenyan Fan, Rui Ma   +8 more
doaj   +1 more source

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity [PDF]

Diabetes & Metabolism Journal, 2014
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and ...
In-Kyu Lee
doaj   +1 more source

Bidirectional Two-Sample Mendelian Randomization Analysis Unveils a Causal Correlation of Mitochondrial Function-Related Proteins with the Risk of Diabetic Nephropathy

International Journal of Clinical Practice
Objective. The genuine causal nexus between mitochondrial function-related proteins and diabetic nephropathy remains enigmatic and arduous to delineate conclusively.
Siyuan Song, Jiangyi Yu
doaj   +1 more source

The causal relationships between mitochondria and six types of cancer: a Mendelian randomization study

BMC Cancer
Background Mitochondria play a multifaceted role in tumorigenesis, influencing energy metabolism, redox balance, and apoptosis. However, whether mitochondrial traits causally affect cancer risk remains unclear.
Jincheng Tang, Jingting Zhang, Renyi Yang, Hongyao Chen, Xiaopeng Yu, Wei Peng, Puhua Zeng   +6 more
doaj   +1 more source

Mitochondria: from powerhouses of cells to hubs in antitumor immunity. [PDF]

Front Immunol
Li X, Shi Y, Zhao Y, Zhu G, Jin L.
europepmc   +1 more source

2-MCPD-Induced Effects in the Heart: Toxicological and Mechanistic Implications from Comparative Proteomic Analyses in Rats. [PDF]

Molecules
Oberemm A, Eisenreich A, Sommerkorn K, Reinhold A, Meckert C, Götz ME.   +5 more
europepmc   +1 more source

Comparative proteomics of bark and xylem provides insights into age-dependent corticular photosynthesis in <i>Eucalyptus grandis</i>. [PDF]

Front Plant Sci
da Silva FAR, de Lima DC, Labate MTV, Budzinski IGF, Cataldi TR, Labate CA.   +5 more
europepmc   +1 more source

Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review). [PDF]

Int J Mol Med
Chen L, Gao F, Mei Q, Li Y, Cai Q, Feng X.   +5 more
europepmc   +1 more source