Results 31 to 40 of about 9,755 (167)

The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes [PDF]

, 2008
Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”.
Rakesh Sharma
core   +1 more source

Transcriptome analysis of an oil-rich race B strain of Botryococcus braunii (BOT-22) by de novo assembly of pyrosequencing cDNA reads [PDF]

, 2012
To gain genetic insights into the biosynthesis of botryococcene oils in Botryococcus braunii race B, a transcriptome dataset of the BOT-22 strain containing 27,427 non-redundant sequences assembled from 209,429 complementary DNA reads was obtained via ...
Baba Masato, Ioki Motohide, Nakajima Nobuyoshi, Shiraiwa Yoshihiro, Watanabe Makoto M., 渡邉 信, 白岩 善博, 馬場 将人   +7 more
core   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Engineering New-to-Nature Biological Pathways for β,γ-Alkanediol Synthesis. [PDF]

Adv Sci (Weinh)
β,γ‐Alkanediols are value‐added chemicals to be used as functional solvents, biofuels, and cosmetic components. This work demonstrates a carboligation‐mediated approach for synthesis of linear chain β,γ‐alkanediols in Escherichia coli, namely, hexane‐2,3‐diol (2,3‐HDO) and pentane‐2,3‐diol (2,3‐PDO). The engineered E. coli cells produce 152.2 mm (17.98
Chen H, Yu H, Lin D, Yang G, Xie Y, Zhang Y, Yuan J.   +6 more
europepmc   +2 more sources

Influence of nutritional and operational parameters on the production of butanol or 1,3-propanediol from glycerol by a mutant Clostridium pasteurianum [PDF]

, 2017
Butanol and 1,3-propanediol (1,3-PDO) are simultaneously produced by Clostridium pasteurianum from glycerol. In this study, random chemical mutagenesis of C. pasteurianum DSM 525 was conducted to improve its tolerance to butanol. Selected nutritional and
Alves, M. M., Marusich, R., Rodrigues, L. R.   +2 more
core   +1 more source

Insight into the Carboxyl Transferase Domain Mechanism of Pyruvate Carboxylase from \u3cem\u3eRhizobium etli\u3c/em\u3e [PDF]

, 2009
The effects of mutations in the active site of the carboxyl transferase domain of Rhizobium etli pyruvate carboxylase have been determined for the forward reaction to form oxaloacetate, the reverse reaction to form MgATP, the oxamate-induced ...
Attwood, Paul V, Cleland, W Wallace, Jitrapakdee, Sarawut, Maurice, Martin St., Wallace, John C., Zeczycki, Tonya N.   +5 more
core   +1 more source

Lipid metabolic perturbation is an early-onset phenotype in adult spinster mutants: a Drosophila model for lysosomal storage disorders [PDF]

, 2017
Intracellular accumulation of lipids and swollen dysfunctional lysosomes are linked to several neurodegenerative diseases, including lysosomal storage disorders (LSD).
Acharya JK, Acharya U, Avinash Khandelwal, Bilen J, Billeter JC, Brankatschk M, Carvalho M, Carvalho M, Cheng H, Cutler RG, Dasgupta U, Dermaut B, Dominik Schwudke, Ejsing CS, Fergestad T, Georgakopoulou EA, Ghosh A, Gray DA, Guan XL, Gutierrez E, Han X, Hebbar S, Hebbar S, Herzog R, Hickey AJ, Hindle S, Hindle SJ, Hoglinger D, Ito M, Jang S, Joanne Y. Yew, Julie Brill, Kawahara A, Kumarasamy SK, Lim A, Liu L, Lloyd-Evans E, Matyash V, Mi H, Milton VJ, Nakano Y, Osborne N, Palm W, Panchal M, Pantoja M, R. Jayashree, Rohrbough J, Rong Y, Samantha J. Hindle, Sampaio JL, Sarita Hebbar, Sasamura T, Schneider CA, Schwudke D, Sean T. Sweeney, Seppo A, Shevchenko A, Shevchenko A, Starostina E, Stern CA, Sweeney ST, te Vruchte D, Thomas PD, Venkatachalam K, Xu Y, Yew JY, Yin Ning Chiang, Zigdon H   +67 more
core   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source