Results 11 to 20 of about 4,380 (169)

Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle [PDF]

, 2021
The role of pyruvate dehydrogenase in mediating lipid-induced insulin resistance stands as a central question in the pathogenesis of type 2 diabetes mellitus.
Hurd, Ralph E, Hurd, Ralph E., Josan, Sonal, Mayer, Dirk, Havel, Peter, Spielman, Daniel M, Hurd, Ralph, Park, Jae Mo, Chung, Youngran, Spielman, Daniel, Bendahan, David, Havel, Peter J, Havel, Peter J., Spielman, Daniel M., Graham, James, Jue, Thomas   +15 more
core   +1 more source

The NADPH oxidase NOX4 regulates redox and metabolic homeostasis preventing HCC progression

Hepatology, EarlyView., 2022
Loss of NOX4 in HCC tumor cells induces metabolic reprogramming in a Nrf2/MYC‐dependent manner to promote HCC progression. Abstract Background and Aims The NADPH oxidase NOX4 plays a tumor‐suppressor function in HCC. Silencing NOX4 confers higher proliferative and migratory capacity to HCC cells and increases their in vivo tumorigenic potential in ...
Irene Peñuelas‐Haro, Rut Espinosa‐Sotelo, Eva Crosas‐Molist, Macarena Herranz‐Itúrbide, Daniel Caballero‐Díaz, Ania Alay, Xavier Solé, Emilio Ramos, Teresa Serrano, María L. Martínez‐Chantar, Ulla G. Knaus, José M. Cuezva, Antonio Zorzano, Esther Bertran, Isabel Fabregat   +14 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Pyruvate dehydrogenase E1α deficiency in a family: Different clinical presentation in two siblings [PDF]

, 1998
The pyruvate dehydrogenase (PDH) complex (PDHc) is responsible for the irreversible conversion of pyruvate to acetyl-CoA. PDHc is a multienzyme complex consisting of three catalytic subunits, pyruvate decarboxylase (E1), dihydrolipoamideacetyltransferase
L. De Meirleir, W. Lissens, Lissens, Willy, S. Seneca1, Seneca, Sara, N. Specola, Spècola, Norma, De Meirleir, L.   +7 more
core   +2 more sources

The dynamic organization of fungal acetyl-CoA carboxylase [PDF]

, 2016
Acetyl-CoA carboxylases (ACCs) catalyse the committed step in fatty-acid biosynthesis: the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. They are important regulatory hubs for metabolic control and relevant drug targets for the treatment of ...
Hagmann, Anna, Imseng, Stefan, Hunkeler, Moritz, Stuttfeld, Edward, Maier, Timm   +4 more
core   +1 more source

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis [PDF]

, 2021
International audienceToxoplasmosis, a protozoan infection caused by Toxoplasma gondii, is estimated to affect around 2.5 billion people worldwide.
Nisimura, Lindice, Mitie, Veiga, Alan, de Almeida, Nardelli, Sheila,, Vommaro, Rossiane,, Nisimura, Lindice,, Araújo-Silva, Carlla, Assis, de Veiga, A., Mariano, A., Silber, Ariel,, Nardelli, S., Ferrarini, Mariana, Galvão, Fragoso, Mariana, Sayuri Ishikawa, Abud, Ana, Paula Ressetti, Ávila, Andréa Rodrigues, Abud, Ana,, Nisimura, L., Rodrigues, A., Vommaro, Rossiane, C, Abud, A., Silber, Ariel, Mariano, France-Sagota, M., Fragoso, Mariana,, Ferrarini, M., Girard, R., Fragoso, M., Ferrarini, Mariana,, Girard, Richard,, Alencar, M., Alencar, Mayke, Bezerra, Vommaro, R., Araújo-Silva, C., Girard, Richard, Marcel Bruno Moreira, Nardelli, Sheila, Cristina, Veiga, Alan,, Sagot, Marie-France, Alencar, Mayke,, Araújo-Silva, Carlla,   +36 more
core   +1 more source

Pyruvate Dehydrogenase A1 Phosphorylated by Insulin Associates with Pyruvate Kinase M2 and Induces LINC00273 through Histone Acetylation

, 2022
Insulin potently promotes cell proliferation and anabolic metabolism along with a reduction in blood glucose levels. Pyruvate dehydrogenase (PDH) plays a pivotal role in glucose metabolism.
Dogsom, Oyungerel, Islam, Rokibul, Kim Cuong Cap, Hossain, Abu Jubayer, Jae-Bong Park, Cap, Kim Cuong, Park, Jae-Bong, Jae-Gyu Kim, Oyungerel Dogsom, Rokibul Islam, Abu Jubayer Hossain, Kim, Jae-Gyu   +11 more
core   +1 more source

Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype [PDF]

, 2019
Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which inhibits the pyruvate dehydrogenase-mediated conversion of ...
Hui Eon Kim, Lee, Taeho, Ha, Chae-Myeong, Kim, Dong Wook, Keun-Gyu Park, Park, Keun-Gyu, Byong-Keol Min, Jung Yi Lee, Oh, Chang Joo, Kim, Hui Eon, Lee, Jongsoon, Ham, Hye Jin, Robert A. Harris, Min, Byong-Keol, Jeon, Jae-Han, Sungmi Park, Hyeon, Do Young, Do Young Hyeon, Park, Sungmi, Dong Wook Kim, Ajay Chawla, Hyeon-Ji Kang, In-Kyu Lee, Byung-Gyu Kim, Yoo, Eun Kyung, Byung-Jun Choi, Lee, Jung Yi, Choi, Byung-Jun, Jung-whan Kim, Daehee Hwang, Chawla, Ajay, Yeon-Kyung Choi, Chang Joo Oh, Choi, Yeon-Kyung, Harris, Robert A., Kang, Hyeon-Ji, Hwang, Daehee, Kim, Jung-whan, Jae-Han Jeon, Lee, Chul-Ho, Eun Kyung Yoo, Yong-Hoon Kim, Kim, Byung-Gyu, Lee, In-Kyu, Hye Jin Ham, Chul-Ho Lee, Kim, Yong-Hoon, Taeho Lee, Jongsoon Lee, Chae-Myeong Ha   +49 more
core   +2 more sources

Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics. [PDF]

Clin Transl Med
1. Lactate‐derived histone lactylation links glycolytic reprogramming to epigenetic regulation in female reproductive diseases. 2. In endometriosis, lactylation may promote inflammatory remodelling, immune dysregulation and ferroptosis resistance. 3. In PCOS, lactylation connects metabolic disturbance to granulosa‐cell dysfunction and hyperandrogenism.
Qiao J, Xiao Y, Cheng Y, Xu W, Shu J, Li S.   +5 more
europepmc   +2 more sources

Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma.

, 2005
Pyruvate dehydrogenase (PDH) catalyzes the conversion of pyruvate to acetyl-coenzyme A, which enters into the Krebs cycle, providing adenosine triphosphate (ATP) to the cell.
Harris, AL, Koukourakis, MI, Giatromanolaki, A, Sivridis, E, Gatter, KC   +4 more
core   +2 more sources